SILVIA VANESSA LOURENCO
Projetos de Pesquisa
Unidades Organizacionais
ODE, FO - Docente
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina - Líder
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
conferenceObject Contribution of apoptosis to human salivary gland lumen formation: Importance of basic science(2014) TESHIMA, T.; COUTINHO-CAMILLO, C.; IANEZ, R.; TUCKER, A.; LOURENCO, S. V.conferenceObject IgG4-related disease: Salivary glands peculiarities and differences with Sjogren's Syndrome(2014) BOLOGNA, S.; NUNES, T.; COUTINHO-CAMILLO, C.; PASOTO, S.; MACHADO, B.; NICO, M.; LOURENCO, S.article 8 Citação(ões) na Scopus Melanoma in Children, Adolescents, and Young Adults: A Clinical Pathological Study in a Brazilian Population(2014) SANCHEZ, Paula C. F.; NODA, Aliene Y. I.; FRANCO, Dilcilea D. G. S.; LOURENCO, Silvia V.; SANGUEZA, Martin; NETO, Cyro F.Malignant melanoma in children, adolescents, and young adults is unusual, especially before puberty. In children (age, 0-14 years), most primary lesions are thick and atypical (amelanotic, simulating pyogenic granuloma). In the population of adolescents and young adults (age, 15-39 years), melanoma is the third most common cancer, only behind lymphoma and breast cancer. Our study investigated the records of 89 patients diagnosed with cutaneous melanoma at age 0-39 years at Hospital das Cl nicas, Medical School, University of Sao Paulo between 1992 and 2002. They were divided into group A (0-14 years of age) and group B (15-39 years of age). The histopathology of all cases was reexamined. Statistical analysis of the data presented was performed, and the obtained data were compared with the literature. The frequency of melanoma in the group aged 15-39 years was higher in women, and the most affected site was the trunk. Additionally, melanomas were more frequent at an earlier age in patients with family history of melanoma (P = 0.014). Most cases were diagnosed, at histopathology, as superficial spreading melanoma. Thick nodular melanomas with Breslow values higher than 2 mm were associated with lymph node metastasis (P < 0.05). Our study revealed that melanoma in children, adolescents, and young adults may present peculiar behavior and outcome, which might reflect the genetic and yet not fully unraveled pathogenesis of this complex disease.- An Atrophic, Telangiectatic Patch at the Distal Border of the Tongue: A Mucous Membrane Manifestation of Xeroderma Pigmentosum(2014) BOLOGNA, Sheyla Batista; TESHIMA, Tathyane Harumi Nakajima; LOURENCO, Silvia Vanessa; NICO, Marcello Menta SimonsenXeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by clinical and cellular sensitivity, pigmentary changes, and early development of malignancies in sun-exposed mucocutaneous and ocular structures due to a defective ability to repair intracellular DNA damage. Individuals with XP also have a greater frequency of oral cancer, particularly squamous cell carcinoma of the anterior third of the tongue. The current study reports four cases of XP that exhibited a characteristic crescent-shaped, atrophic, telangiectatic area on the distal border of the tongue and correlates this lesion with the development of tumors at this site during follow-up. The tongue lesion was photographed and biopsied in the four patients. During routine follow-up visits, new biopsies were performed if additional tongue lesions were observed. The studied lesions were similar in the four patients. During follow-up, squamous cell carcinoma developed in one patient and pyogenic granuloma developed in three patients and was relapsing in one. The lesion remained stable in one patient during the study. The atrophic and telangiectatic patches probably occur because of chronic sun damage to the exposed portion of the tongue, and this area has a high predisposition for the development of benign and malignant tumors.
conferenceObject Primary oral mucosal melanoma: Are NRAS and BRAF mutations determinant in its pathogenesis?(2014) NICO, M. Menta S.; HSIEH, R.; CAMILLO-COUTINHO, C.; FERNANDES, J. Dumet; LOURENCO, S. V.- Porcelain-yellow papule in an 8-year-old girl(2014) LOURENCO, Silvia Vanessa; TESHIMA, Tathyane Harumi Nakajima; NAGANO, Cibele Pidorodeski; FERNANDES, Juliana Dumet; NICO, Marcello Menta Simonsen
conferenceObject Melanoma in children, adolescents, and young adults: A clinicopathologic study in a Brazilian population(2014) NODA, Aliene; NETO, Cyro; FRANCO, Dilcilea; SANGUEEZA, Martin; SANCHEZ, Paula; LOURENCO, SilviaconferenceObject Phenotypical analysis of primary and metastatic adenoid cystic carcinoma of salivary glands: Cytokeratins profile(2014) LOURENCO, S. V.; PIDORODESKI, C.; CAMILLO-COUTINHO, C.; IANEZ, R. Fraga; PINTO, C.; FONSECA, I.