SILVIA VANESSA LOURENCO

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LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • conferenceObject
    microRNAs associated with metastatic potential in salivary gland mucoepidermoid carcinoma
    (2023) TREVIZANI, Maria Eduarda S.; OLIVEIRA, Katia K.; MARCHI, Fabio A.; BIZINELLI, Daniela; MARIANO, Fernanda V.; NAGANO, Cibele P.; COSTA, Felipe A.; PINTO, Clovis A.; KOWALSKI, Luiz P.; LOURENCO, Silvia V.; COUTINHO-CAMILLO, Claudia M.
  • article 0 Citação(ões) na Scopus
    Relevant proteins for the monitoring of engraftment phases after allogeneic hematopoietic stem cell transplantation
    (2022) SOUZA, Milena Monteiro; COUTINHO-CAMILLO, Claudia Malheiros; PAULA, Fabiana Martins de; PAULA, Fernanda de; BOLOGNA, Sheyla Batista; LOURENCO, Silvia Vanessa
    Introduction: Hematopoietic Stem Cell Transplant (HSCT) has been successfully used as standard therapy for hematological disorders. After conditioning therapy, patients undergoing allogeneic HSCT, present three different phases of engraftment: early pre-engraftment, early post-engraftment, and late engraftment. Severe complications are associated with morbidity, mortality, and malignancies in these phases, which include effects on the oral cavity.Objectives: The changes in the salivary composition after HSCT may contribute to identifying relevant proteins that could map differences among the phases of diseases, driven for personalized diagnostics and therapy.Methods: Unstimulated whole saliva was collected from patients submitted to HSCT. The samples were submitted to trypsin digestion for a Mass spectrometry analysis. MaxQuant processed the Data analysis, and the relevant expressed proteins were subjected to pathway and network analyses.Results: Differences were observed in the most identified proteins, specifically in proteins involved with the regu-lation of body fluid levels and the mucosal immune response. The heatmap showed a list of proteins exclusively expressed during the different phases of HSCT: HBB, KNG1, HSPA, FGB, APOA1, PFN1, PRTN3, TMSB4X, YWHAZ, CAP1, ACTN1, CLU and ALDOA. Bioinformatics analysis implicated pathways involved in protein proc-essing in the endoplasmic reticulum, complement and coagulation cascades, apoptosis signaling, and cholesterol metabolism.Conclusion: The compositional changes in saliva reflected the three phases of HSCT and demonstrated the useful-ness of proteomics and computational approaches as a revolutionary field in diagnostic methods.