EUCLIDES AYRES DE CASTILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina
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article 8 Citação(ões) na Scopus HIV/AIDS epidemic in Brazil: three decades(2011) SZWARCWALD, Celia Landmann; CASTILHO, Euclides Ayres deconferenceObject Antiretroviral Therapy at Public Health Care Facilities in Brazil: HIV/AIDS Cohort-Brazil.(2015) ESCUDER, M. M. L.; GRANGEIRO, A. M.; CASSENOTE, A. J. F.; KALICHMAN, A. O.; SOUZA, R. A.; TUPINAMBA, U.; VELOSO, V.; BARCELLOS, N.; GRINSZTEJN, B.; CASTILHO, E. A.- Spatial distribution of the human development index, HIV infection and AIDS-Tuberculosis comorbidity: Brazil, 1982 - 2007(2014) RODRIGUES-JÚNIOR, Antonio Luiz; RUFFINO-NETTO, Antonio; CASTILHO, Euclides Ayres deINTRODUCTION: AIDS epidemic has given visibility to the incidence of tuberculosis, for being the most frequent opportunistic infection. It is known that individuals who are socially vulnerable are more susceptible to HIV transmission and tuberculosis as well. OBJECTIVE: This study aims to conduct a geoepidemiological study on HIV/AIDS, AIDS-Tuberculosis co-infection and social vulnerability. METHOD: This is an ecological study using incidence rates and the human development index to produce thematic maps and a descriptive analysis of epidemiology. The records of reported cases of HIV/AIDS from 1982 to 2007 were used, considering as cases of AIDS-Tuberculosis those records that were positively diagnosed with tuberculosis and those records with unknown diagnosis of tuberculosis, but showing compatible signs and symptoms with tuberculosis (fever, cough, cachexia and asthenia). RESULTS: The maps allowed the identification of areas with social differences and different patterns of incidence of HIV/AIDS and AIDS-Tuberculosis; regional differences were similar to those found by Josué de Castro, in 1940; regions with higher human development index values also showed higher incidence HIV/AIDS and AIDS-Tuberculosis. CONCLUSION: The prevention of HIV infection must be geographically specific, given socioeconomic and cultural differences. Although official records show decline in AIDS-TB co-infection, treatment of cases of HIV/AIDS should observe the occurrence of opportunistic diseases, which should be notified and/or updated.
- Sexual behavior and self-declaration of sexual orientation among people 18-64 years in Brazil: results from the Knowledge, Attitudes, and Practices survey, 2013 and the National Health Survey, 2019(2023) SZWARCWALD, Celia Landmann; PASCOM, Ana Roberta Pati; SOUZA JUNIOR, Paulo Roberto Borges de; DAMACENA, Giseli Nogueira; CASTILHO, Euclides AyresBackground Population surveys involving the monitoring of high-risk sexual behavior have been recognized as important public health tools to control the HIV epidemic and other sexually transmitted infections (STIs). Methods Using data from the Knowledge, Attitudes, and Practices survey (PCAP-2013) and from the National Health Survey (PNS-2019), indicators of sexual behavior were compared according to sociodemographic characteristics among individuals aged 18-64 years, including size (%) estimates of men who have sex with men (MSM) and women who have sex with women (WSW). Specifically, the PNS-2019 prevalence estimates of homosexual, bisexual, heterosexual males and females were compared with those from the PCAP-2013. To compare PCAP and PNS proportional distributions, the Pearson's chi-square test, adjusted by the Rao-Scott's correction, was applied. Results Size (%) estimates of MSM and WSW obtained by direct questions from the PCAP-2013, showed higher homosexuality prevalence estimates than those resulting from the PNS-2019 self-declared sexual orientation. Significant differences were found between the MSM proportions according to the PCAP-2013 (3.7%; 95% CI 3.1-4.4%) and to the PNS-2019 (2.2%; 95% CI 1.9-2.5), and between the WSW proportions (4.6%; 95% CI 4.0-5.4%) and (2.1%; 95% CI 1.8-2.4), respectively. Results from both surveys showed MSM and WSW prevalence estimates increase with educational level, decrease with age, and is larger among people who do not live with partner, live in urban areas and in state capitals. Regarding condom use at last sexual intercourse, no differences between the PCAP-2013 and the PNS-2019 estimates were found at the national level, but significant improvements were found for MSM, people aged 18-24 and 25-34 years, and individuals not living with a partner. Conclusions The underestimation of MSM and WSW prevalence by self-declared sexual orientation suggests that sexual minorities face many difficulties related to disclosing their sexuality and reinforces the importance of developing public health interventions for changing population attitudes and promoting sexual orientation disclosure. Moreover, the low use of condoms in both surveys (PCAP-2013 and PNS-2019) carried out 6 years apart highlights the need of public policies to expand prevention strategies for HIV infection and other STIs.
- Chronic noncommunicable diseases and population surveys(2017) CASTILHO, Euclides Ayres de; GOLDBAUM, Moises
article 16 Citação(ões) na Scopus Self-rated health by HIV-infected individuals undergoing antiretroviral therapy in Brazil(2011) SOUZA JUNIOR, Paulo Roberto Borges de; SZWARCWALD, Celia Landmann; CASTILHO, Euclides Ayres deIn 2008, a survey was applied to a probabilistically selected sample of 1,245 HIV-infected patients on antiretroviral therapy in Brazil. In this work, the analysis was focused on self-rated health. The analysis was conducted according to sex, age, socioeconomic variables, and clinical and treatment-related patient characteristics. Through stepwise logistic regression procedures, the main predictors of good perception of health status were established. Results showed that 65% self-rated health state as good or excellent, 81% do have no or slight difficulty in following treatment, but 34% men and 47% women reported intense or extreme degree of anxiety/worry feelings. Educational level, work situation, presence of side effects and AIDS-related symptoms were the main predictors of good self-perception of health. Problems related to animus status, involving worry and anxiety about the future are still barriers that must be overcome to improve quality of life of people living with HIV/AIDS.article 8 Citação(ões) na Scopus Evaluation of strategies by the Brazilian Ministry of Health to stimulate the municipal response to AIDS(2011) GRANGEIRO, Alexandre; ESCUDER, Maria Mercedes Loureiro; CASTILHO, Euclides Ayres deThe aim of this study was to evaluate strategies by the Brazilian Ministry of Health to expand the municipal response to AIDS. Cities ""included"" and ""not included"" in Federal strategies for ""municipalization"" of the response were compared according to the response profile and trends in the epidemic. Multinomial logistic regression was used, among other statistical procedures. Municipalities included from 1994 to 1998 showed higher chances of providing HIV diagnostic testing [OR = 15.0; 95% CI: 5.6-40.1], of having AIDS services [OR = 18.4; 95% CI: 8.4-40.5], and reducing cases involving heterosexual [OR = 3.1; 95% CI: 1.4-7.3], homosexual/bisexual [OR = 3.0; 95% CI: 1.4-6.2], and IDU transmission [OR = 6.6; 95% CI: 2.9-14.9] as compared to those ""included in 2003"" and ""not included"". There were no associations between the included Municipalities, greater coverage in prevention, the reduction in cases due to vertical transmission or blood transfusion, or mortality rates. Municipalities with a more structured response were associated with better results. The findings suggest that the municipalization policy contributed to improvement in the local response to AIDS.- Adverse event occurrence following use of tetanus, diphtheria and acellular pertussis adsorbed vaccine - Tdap -, Sao Paulo, SP, Brazil, 2015-2016(2020) GATTAS, Vera Lucia; LUNA, Expedito Jose Albuquerque; SATO, Ana Paula Sayuri; FERNANDES, Eder Gatti; VAZ-DE-LIMA, Lourdes Ra; SATO, Helena Keiko; CASTILHO, Euclides A. deObjective: to describe occurrence of adverse events following immunization (AEFI) with Tdap vaccine during pregnancy. Methods: this was a descriptive study using data from reports by participants in an effectiveness and immunogenicity study conducted in two hospitals in Sao Paulo, SP, Brazil, from 2015 to 2016. Results: of the 201 mothers included in the study, 48 (23.9%) had at least one AEFI; 60 symptoms related to Tdap use were identified - pain (22.4%), swelling (2.5%), fever (1.5%), somnolence (1.0%), redness (0.5%), vomiting (0.5%), headache (0.5%), local reaction (0.5%), and fatigue (0.5%); no rare, very rare, or extremely rare adverse events were reported; all events were considered to be expected, as they are described in the vaccine package insert; outcome of all events was recovery without sequelae. Conclusion: Tdap vaccine in the form adopted by the National Immunization Program is safe; no unexpected adverse events were identified among vaccinated pregnant women.
- A call for a more comprehensive SARS-CoV-2 sequence database for Brazil(2022) ABBUD, Adriano; CASTILHO, Euclides Ayres
- Health problems and the rural area(2018) CASTILHO, Euclides Ayres de; GONCALVES, Helen