REMO HOLANDA DE MENDONCA FURTADO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
6 resultados
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- The Use of Oral Beta-Blockers and Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: a Long-Term Follow-Up Study(2018) NICOLAU, Jose C.; FURTADO, Remo H. M.; BARACIOLI, Luciano M.; LARA, Livia M.; DALCOQUIO, Talia F.; SCANAVINI JUNIOR, Marco A.; PEREIRA, Cesar A. C.; LIMA, Viviane M.; GONCALVES, Talita M.; COLODETTI, Raiza; FERRARI, Aline G.; LOPES, Renato D.; GIUGLIANO, Robert P.BackgroundThe role of beta-blockers in patients with acute coronary syndromes is mainly derived from studies including patients with ST-segment elevation myocardial infarction. Little is known about the use of beta-blockers and associated long-term clinical outcomes in patients with non-ST-elevation acute coronary syndromes (NSTEACS).MethodsWe analyzed short- and long-term clinical outcomes of 2921 patients with NSTEACS using or not oral beta-blockers in the first 24h of the acute coronary syndromes (ACS) presentation. The association between beta-blocker use and mortality was assessed using a propensity score adjusted analysis (N=1378).ResultsPatients starting oral beta-blockers in the first 24h of hospitalization, compared with patients who did not, had lower rates of in-hospital mortality (OR=0.52, 95% CI 0.33 to 0.74, P=0.002) and higher mean survival times in the long-term follow-up (11.860.4years vs. 9.92 +/- 0.39years, P<0.001).Conclusion The use of beta-blockers in the first 24h of patients presenting with NSTEACS was associated with better in-hospital and long-term mortality outcomes.
- Is adenosine associated with sudden death in schizophrenia? A new framework linking the adenosine pathway to risk of sudden death(2018) GADELHA, Ary; ZUGMAN, Andre; CALZAVARA, Mariana Bendlin; FURTADO, Remo Holanda de Mendonca; SCORZA, Fulvio Alexandre; BRESSAN, Rodrigo AfonseccaSchizophrenia is associated with an increased mortality from cardiovascular disease. Relatively few studies have assessed the putative association of schizophrenia pathophysiology with sudden death. Low adenosine levels have been associated with schizophrenia. In cardiology, increased mortality among patients with congestive heart failure has been associated with genetic polymorphisms that potentially lead to lower adenosine levels. Thus, we hypothesize that adenosine could link schizophrenia and cardiovascular mortality, with decreased adenosine levels leading to increased vulnerability to hyperexcitability following hypoxic insults, increasing the odds of fatal arrhythmias. Low adenosine levels might also lead to a small increase in overall mortality rates and a major increase in the sudden death rate. This hypothesis paves the way for further investigation of the increased cardiac mortality associated with schizophrenia. Potentially, a better characterization of adenosine related mechanisms of sudden death in schizophrenia could lead to new evidence of factors leading to sudden death in the general population.
bookPart Síndrome coronária aguda com supradesnível do segmento ST(2018) NICOLAU, José Carlos; FURTADO, Remo Holanda de MendonçaconferenceObject Predictors of returning to work in the long-run after an acute coronary syndrome episode(2018) NICOLAU, J. C.; LARA, L.; DALCOQUIO, T.; BARACIOLI, L. M.; FURTADO, R. H. M.; FRANCI, A.; COSTA, M. S. S.; FERRARI, A. G.; SCANAVINI FILHO, M. A.; GODOY, L. C.; RAMIRES, J. A. F.; KALIL-FILHO, R.; SILVA, J. C.- Stem-cell therapy in ST-segment elevation myocardial infarction with reduced ejection fraction: A multicenter, double-blind randomized trial(2018) NICOLAU, Jose C.; FURTADO, Remo H. M.; SILVA, Suzana A.; ROCHITTE, Carlos E.; RASSI JR., Anis; MORAES JR., Joao B. M. C.; QUINTELLA, Edgard; COSTANTINI, Costantino R.; KORMAN, Adrian P. M.; MATTOS, Marco A.; CASTELLO JR., Helio J.; CAIXETA, Adriano; DOHMANN, Hans F. R.; CARVALHO, Antonio C. C. deBackgroundLeft ventricular ejection fraction (LVEF) is a major determinant of long-term prognosis after ST-segment elevation myocardial infarction (STEMI). STEMI patients with reduced LVEF have a poor prognosis, despite successful reperfusion and the use of renin-angiotensin-aldosterone inhibitors. HypothesisIntracoronary infusion of bone marrow-derived mononuclear cells (BMMC) may improve LVEF in STEMI patients successfully reperfused. MethodsThe main inclusion criteria for this double-blind, randomized, multicenter study were patient age 30 to 80years, LVEF 50%, successful angioplasty of infarct-related artery, and regional dysfunction in the infarct-related area analyzed before cell injection. Cardiac magnetic resonance imaging was used to assess LVEF, left ventricular volumes, and infarct size at 7 to 9days and 6months post-myocardial infarction. ResultsOne hundred and twenty-one patients were included (66 patients in the BMMC group and 55 patients in the placebo group). The primary endpoint, mean LVEF, was similar between both groups at baseline (44.63%10.74% vs 42.23%+/- 10.33%; P=0.21) and at 6months (44.74%+/- 12.95 % vs 43.50 +/- 12.43%; P=0.59). The groups were also similar regarding the difference between baseline and 6months (0.11%+/- 8.5% vs 1.27%+/- 8.93%; P=0.46). Other parameters of left ventricular remodeling, such as systolic and diastolic volumes, as well as infarct size, were also similar between groups. ConclusionsIn this randomized, multicenter, double-blind trial, BMMC intracoronary infusion did not improve left ventricular remodeling or decrease infarct size.
bookPart Síndrome coronária aguda com supradesnivel do segmento ST(2018) NICOLAU, José Carlos; FURTADO, Remo Holanda de Mendonça