LUIZ APARECIDO BORTOLOTTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
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- I Brazilian Guidelines On Cardiovascular Prevention(2013) SIMAO, A. F.; PRECOMA, D. B.; ANDRADE, J. P.; CORREA FILHO, H.; SARAIVA, J. F. K.; OLIVEIRA, G. M. M.; MURRO, A. L. B.; CAMPOS, A.; ALESSI, A.; AVEZUM JUNIOR, A.; ACHUTTI, A. C.; MIGUEL, A. C. M. G.; SOUSA, A. C. S.; LOTEMBERG, A. M. P.; LINS, A. P.; FALUD, A. A.; BRANDAO, A. A.; SANJULIANI, A. F.; SBISSA, A. S.; ALENCAR FILHO, A. C.; HERDY, A. H.; POLANCZYK, C. A.; LANTIERI, C. J.; MACHADO, C. A.; SCHERR, C.; STOLL, C.; AMODEO, C.; ARAUJO, C. G. S.; SARAIVA, D.; MORIGUCHI, E. H.; MESQUITA, E. T.; CESENA, F. H. Y.; FONSECA, F. A. H.; CAMPOS, G. P.; SOARES, G. P.; FEITOSA, G. S.; XAVIER, H. T.; CASTRO, I; GIULIANO, I. C. B.; V, I. Rivera; GUIMARAES, I. C. B.; ISSA, J. S.; SOUZA, J. R. M.; FARIA NETO, J. R.; CUNHA, L. B. N.; PELLANDA, L. C.; BORTOLOTTO, L. A.; BERTOLAMI, M. C.; MINAME, M. H.; GOMES, M. A. M.; TAMBASCIA, M.; MALACHIAS, M. V. B.; SILVA, M. A. M.; IZA, M. C. O.; MAGALHAES, M. E. C.; BACELLAR, M. S. C.; MILANI, M.; WAJNGARTEN, M.; GHORAYEB, N.; COELHO, O. R.; VILLELA, P. B.; V, P. C. B. Jardim; SANTOS FILHO, R. D.; STEIN, R.; CASSANI, R. S. L.; D'AVILA, R. L.; FERREIRA, R. M.; BARBOSA, R. B.; POVOA, R. M. S.; KAISER, S. E.; ISMAEL, S. C.; CARVALHO, T.; GIRALDEZ, V. Z. R.; COUTINHO, W.; SOUZA, W. K. S. B.
conferenceObject HDL FUNCTIONALITY MODULATES CAROTID ARTERY INTIMA-MEDIA THICKNESS IN INDIVIDUALS WITH MARKED HYPERALPHALIPOPROTEINEMIA(2016) LAURINAVICIUS, Antonio; ROCHA, Viviane; BORTOLOTTO, Luiz; SANTOS, RaulconferenceObject Pre-implantation interlead EKG heterogeneity is superior to QRS complex duration in predicting mechanical super-response and survival in patients receiving cardiac resynchronization therapy(2020) BORTOLOTTO, A. L.; VERRIER, R. L.; NEARING, B. D.; MARUM, A. A.; SILVA, B. Araujo; PEDREIRA, G.; SILVA, F. Tessarolo; MEDEIROS, S. A.; SROUBEK, J.; ZIMETBAUM, P.; CHANG, J. D.- High Dose of N-Acetylcystein Prevents Acute Kidney Injury in Chronic Kidney Disease Patients Undergoing Myocardial Revascularization(2014) SANTANA-SANTOS, Eduesley; GOWDAK, Luis Henrique W.; GAIOTTO, Fabio A.; PUIG, Luiz B.; HAJJAR, Ludhmila A.; ZEFERINO, Suely P.; DRAGER, Luciano F.; SHIMIZU, Maria Heloisa M.; BORTOLOTTO, Luiz A.; LIMA, Jose J. G. DeBackground. The renoprotective effect of N-acetylcystein in patients undergoing coronary artery bypass graft surgery is controversial. Methods. We assessed the renoprotective effect of the highest dose of N-acetylcystein sanctioned for clinical use in a prospective, double-blind, placebo-controlled study including 70 chronic kidney disease patients, stage 3 or 4, who underwent coronary artery bypass graft surgery, on cardiopulmonary bypass (CPB) and off CPB, and were randomly allocated to receive either N-acetylcystein 150 mg/kg followed by 50 mg/kg for 6 hours in 0.9% saline or only 0.9% saline. Acute kidney injury was defined by the Acute Kidney Injury Network classification. Results. The incidence of kidney injury was reduced in the N-acetylcystein group (57.1% versus 28.6%, p = 0.016). Nonuse of N-acetylcystein (relative risk 3.58, 95% confidence interval: 1.04 to 12.33, p = 0.04) and cardiopulmonary bypass (relative risk 4.55, 95% confidence interval: 1.28 to 16.15, p = 0.02) were independent predictors of kidney injury. In patients treated with CPB, N-acetylcystein reduced the incidence of kidney injury from 63% to 46%. Oxidative stress was increased in control subjects (p = 0.01) and abolished in patients receiving N-acetylcystein. Conclusions. Maximum intravenous doses of N-acetylcystein reduce the incidence of acute kidney injury in patients with kidney disease undergoing coronary artery bypass graft surgery, abolish oxidative stress, and mitigate the negative effect of CPB on renal function. (C) 2014 by The Society of Thoracic Surgeons
- Arterial Stiffness: Pathophysiological and Genetic Aspects(2017) ALVIM, Rafael de Oliveira; SANTOS, Paulo Caleb Junior Lima; BORTOLOTTO, Luiz Aparecido; MILL, José Geraldo; PEREIRA, Alexandre da CostaAbstract Cardiovascular diseases (CVD) are the main cause of mortality and it represents a significant percentage of hospitalizations. In the scenario of minimization of costs of the health system, methods that identify subclinical CVD would be important. Some guidelines include the measures of aortic stiffness and intima-media thickness of the carotid artery as methods to identify subclinical CVD in hypertensive patients. The pulse wave velocity (PWV) is the gold standard for the evaluation of arterial stiffness. In this review, we report the pathophysiology, the determinants of arterial stiffness, and justify its inclusion in the assessment of hypertensive patient due its direct association with cardiovascular risk, as show in the I Diretriz Brasileira de Prevenção Cardiovascular. In addition, we raised the main genetic studies of this phenotype, due to its complexity, can be modulated by dozens of genes. However, a better understanding of the relationship genetic-arterial stiffness and, even an intervention based on genotypes, should be achieved in future studies.
article Brazilian Positioning on Resistant hypertension, vol 99, pg 576, 2012(2013) ALESSI, A.; BRANDAO, A. A.; COCA, A.; CORDEIRO, A. C.; NOGUEIRA, A. R.; FEITOSA, A. M.; AMODEO, C.; RODRIGUES, C. I. S.; CALHOUN, D. A.; COELHO, E. B.; PIMENTA, E.; MUXFELDT, E.; CONSOLIN-COLOMBO, F. M.; SALLES, G.; ROSITO, G.; JR, H. Moreno; V, J. F. Martin; YUGAR-TOLEDO, J. C.; BORTOLOTTO, L. A.; SCALA, L. C. N.; SOUSA, M. G.; GOMES, M. A. M.; MALACHIAS, M. V. B.; GUS, M.; PASSARELLI JUNIOR, O.; V, P. C. B. Jardim; TOSCANO, P. R.; SANCHEZ, R. A.; MIRANDA, R. D.; POVOA, R. M. S.; SOUZA, W. K. S. B.- Prevalence of Metabolic Syndrome and Framingham Risk Score in Apparently Healthy Vegetarian and Omnivorous Men(2018) NAVARRO, Julio Cesar Acosta; ANTONIAZZI, Luiza; OKI, Adrian Midori; BONFIM, Maria Carlos; HONG, Valeria; BORTOLOTTO, Luiz Aparecido; ACOSTA-CARDENAS, Pedro; SANDRIM, Valeria; MINAME, Marcio Hiroshi; SANTOS FILHO, Raul Dias dosBackground: Recent studies have shown a lower prevalence of metabolic syndrome (MSyn) in vegetarians (VEG) despite the inconclusive evidence from others. Objective: To verify the association between diet and other lifestyle characteristics and the prevalence of MSyn, cardiovascular risk factors (CRF), and Framingham Risk Score (FRS) in apparently healthy VEG and omnivorous (OMN) men. Methods: In this cross-sectional study, 88 apparently healthy men >= 35 years, 44 VEG and 44 OMN, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C-reactive protein (CRP) and FRS. To test the association between lifestyle and MSyn, Student t test, chi-square test, and multiple logistic regression model were used. A significance level of 5% was considered in all statistical analyses. Results: Several CRF were significantly lower in VEG than in OMN: body mass index, systolic blood pressure, diastolic blood pressure, fasting serum total cholesterol, LDL-cholesterol, apolipoprotein b, glucose, and glycated hemoglobin (all p < 0.05). The FRS mean was lower in VEG than in OMN (2.98 +/- 3.7 vs 4.82 +/- 4.8, p = 0.029). The percentage of individuals with MSyn was higher among OMN than among VEG (52.3 vs.15.9%) (p < 0.001). The OMN diet was associated with MSyn (OR: 6.28 95%CI 2.11-18.71) and alterations in most MSyn components in the multiple regression model independently of caloric intake, age and physical activity. Conclusion: The VEG diet was associated with lower CRF, FRS and percentage of individuals with MSyn.
conferenceObject Impact of hospitalization for checking medication adherence due to resistant and refractory hypertension suspicious on short and mid-term blood pressure control(2020) PIO-ABREU, A.; TRANI-FERREIRA, F.; V, G. Silva; BORTOLOTTO, L. A.; DRAGER, L.- Posicionamento Brasileiro sobre Hipertensao Arterial Resistente - 2020 (vol 114, pg 576, 2020)(2020) YUGAR-TOLEDO, Juan Carlos; MORENO JUNIOR, Heitor; GUS, Miguel; ROSITO, Guido Bernardo Aranha; SCALA, Luiz Cesar Nazario; MUXFELDT, Elizabeth Silaid; ALESSI, Alexandre; BRANDAO, Andrea Araujo; MOREIRA FILHO, Osni; FEITOSA, Audes Diogenes de Magalhaes; PASSARELLI JUNIOR, Oswaldo; SOUZA, Dilma do Socorro Moraes de; AMODEO, Celso; BARROSO, Weimar Kunz Sebba; GOMES, Marco Antonio Mota; PAIVA, Annelise Machado Gomes de; BARBOSA, Eduardo Costa Duarte; MIRANDA, Roberto Dischinger; VILELA-MARTIN, Jose Fernando; NADRUZ JUNIOR, Wilson; RODRIGUES, Cibele Isaac Saad; DRAGER, Luciano Ferreira; BORTOLOTTO, Luiz Aparecido; CONSOLIM-COLOMBO, Fernanda Marciano; SOUSA, Marcio Goncalves de; BORELLI, Flavio Antonio de Oliveira; KAISER, Sergio Emanuel; SALLES, Gil Fernando; AZEVEDO, Maria de Fatima de; MAGALHAES, Lucelia Batista Neves Cunha; POVOA, Rui Manoel dos Santos; MALACHIAS, Marcus Vinicius Bolivar; NOGUEIRA, Armando da Rocha; JARDIM, Paulo Cesar Brandao Veiga; JARDIM, Thiago de Souza Veiga
conferenceObject In vitro transfer of lipids to high density lipoprotein (HDL) and carotid artery intima-media thickness in individuals with marked hyperalphalipoproteinemia(2016) LAURINAVICIUS, A. G.; PASSARELLI, M.; NAKANDAKARE, E.; HONG, V.; BORTOLOTTO, L.; BITTENCOURT, M. S.; CONCEICAO, R. O. D.; SANTOS, R. D.; MARANHAO, R.