LEDA LEME TALIB
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
LIM/27 - Laboratório de Neurociências, Hospital das Clínicas, Faculdade de Medicina
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
- Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis(2018) JOAQUIM, Helena P. G.; ZANETTI, Marcus V.; SERPA, Mauricio H.; BILT, Martinus T. Van de; SALLET, Paulo C.; CHAIM, Tiffany M.; BUSATTO, Geraldo F.; GATTAZ, Wagner F.; TALIB, Leda L.Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naive first-episode psychosis patients (n = 43) at baseline and following symptom remission, and in healthy controls (n = 77). At baseline GSK3B total level was higher in patients (p < 0.001). In schizophrenia spectrum patients (n = 25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n = 18) (p < 0.001; p = 0.027; p = 0.05 respectively). No enzyme changes were found after clinical remission. The implication of this finding for the biology of psychoses warrants further studies to clarify whether increased GSK3B may be useful as a biomarker for psychosis in general, and schizophrenia in particular.
- Antipsychotic drugs decrease iPLA(2) gene expression in schizophrenia(2013) KERR, Daniel Shikanai; TALIB, Leda Leme; YAMAMOTO, Victor Junji; FERREIRA, Aline S.; ZANETTI, Marcus V.; SERPA, Mauricio H.; BUSATTO, Geraldo F.; BILT, Martinus Theodorus Van de; GATTAZ, Wagner Farid
conferenceObject ANTIPSYCHOTIC TREATMENT DECREASED IPLA2 ACTIVITY IN FIRST EPISODE DRUG NAIVE PATIENTS WITH SCHIZOPHRENIA(2014) TALIB, Leda L.; JOAQUIM, Helena; SERPA, Mauricio; BUSATTO, Geraldo; BILT, Martinus van de; ZANETTI, Marcus; GATTAZ, WagnerconferenceObject PLA2 GENE EXPRESSION IN FIRST EPISODE DRUG NAIVE PATIENTS(2014) KERR, Daniel S.; SERPA, Mauricio; TALIB, Leda L.; BILT, Martinus Theodorus Van De; ALCANTARA, Juliana; CHAIM, Tiffany; BUSATTO, Geraldo; ZANETTI, Marcus; GATTAZ, WagnerconferenceObject INCREASED GLYCOGEN SYNTHASE KINASE-3B (GSK-3B) EXPRESSION IN PLATELETS OF FIRST ONSET PSYCHOSIS NON-AFFECTIVE PATIENTS(2014) JOAQUIM, Helena P. G.; TALIB, Leda L.; ZANETTI, Marcus; BILT, Martinus van de; BUSATTO, Geraldo; SERPA, Mauricio; GATTAZ, Wagner- cytochrome P450 genotypes are not associated with refractoriness to antipsychotic treatment (vol 168, pg 587, 2015)(2016) BILT, M. T. van de; PRADO, C. M.; OJOPI, E. P. B.; SOUSA, R. T. de; LOCH, A. A.; ZANETTI, M. V.; TALIB, L. L.; GATTAZ, W. F.
conferenceObject ANTI-PSYCHOTIC TREATMENT DECREASED IPLA2 ACTIVITY IN FIRST EPISODE DRUG NAIVE PATIENTS(2014) TALIB, Leda L.; JOAQUIM, Helena P. G.; SERPA, Mauricio; BUSATTO, Geraldo; BILT, Martinus van de; ZANETTI, Marcus; GATTAZ, Wagner- Cytochrome P450 genotypes are not associated with refractoriness to antipsychotic treatment(2015) BILT, M. T. van de; PRADO, C. M.; OJOPI, E. P. B.; SOUSA, R. T.; LOCH, A. A.; ZANETTI, M. V.; TALIB, L. L.; GATTAZ, W. F.
- Plasma metabolites in first episode psychoses(2019) COSTA, Alana C.; JOAQUIM, Helena P. G.; TALIB, Leda L.; SERPA, Mauricio H.; ZANETTI, Marcus V.; GATTAZ, Wagner F.
- Inflammatory cytokines and white matter microstructure in the acute phase of first-episode psychosis: A longitudinal study(2023) SERPA, Mauricio; DOSHI, Jimit; JOAQUIM, Helena P. G.; VIEIRA, Erica L. M.; ERUS, Guray; CHAIM-AVANCINI, Tiffany M.; CAVALLET, Mikael; GUGLIELMI, Luiza Guilherme; SALLET, Paulo C.; TALIB, Leda; TEIXEIRA, Antonio L.; BILT, Martinus T. van de; MCGUIRE, Philip; GATTAZ, Wagner F.; DAVATZIKOS, Christos; BUSATTO, Geraldo F.; V, Marcus ZanettiObjectives: Schizophrenia-related psychosis is associated with abnormalities in white matter (WM) microstructure and structural brain dysconnectivity. However, the pathological process underlying such changes is unknown. We sought to investigate the potential association between peripheral cytokine levels and WM microstructure during the acute phase of first-episode psychosis (FEP) in a cohort of drug-naive patients.Methods: Twenty-five non-affective FEP patients and 69 healthy controls underwent MRI scanning and blood collection at study entry. After achieving clinical remission, 21 FEP were reassessed; 38 age and biological sex -matched controls also had a second assessment. We measured fractional anisotropy (FA) of selected WM regions -of-interest (ROIs) and plasma levels of four cytokines (IL-6, IL-10, IFN-& gamma;, and TNF-& alpha;).Results: At baseline (acute psychosis), the FEP group showed reduced FA relative to controls in half the examined ROIs. Within the FEP group, IL-6 levels were negatively correlated with FA values. Longitudinally, patients showed increments of FA in several ROIs affected at baseline, and such changes were associated with reductions in IL-6 levels.Conclusions: A state-dependent process involving an interplay between a pro-inflammatory cytokine and brain WM might be associated with the clinical manifestation of FEP. This association suggests a deleterious effect of IL-6 on WM tracts during the acute phase of psychosis.