SONIA MARIA DOZZI BRUCKI

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina

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  • article 25 Citação(ões) na Scopus
    Recalling feature bindings differentiates Alzheimer's disease from frontotemporal dementia
    (2017) CECCHINI, Mario Amore; YASSUDA, Monica Sanches; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; CARTHERY-GOULART, Maria Teresa; PATROCINIO, Flavia; FOSS, Maria Paula; TUMAS, Vitor; LIMA-SILVA, Thais Bento; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.
    It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls. Participants were 32 cognitively intact adults, 35 individuals with AD and 18 with bvFTD. All patients were in the mild dementia stage. Receiver-operating characteristic (ROC) analyses were used to examine the diagnostic accuracy of the STMB. The results showed that AD patients performed significantly worse than controls and bvFTD patients in the STMB test, while the latter groups showed equivalent performance. The bound condition of the STMB test showed an AUC of 0.853, with 84.4% of sensitivity and 80% of specificity to discriminate AD from controls and an AUC of 0.794, with 72.2% of sensitivity and 80% of specificity to differentiate AD from bvFTD. Binding deficits seem specific to AD. The free recall version of the STMB test can be used for clinical purposes and may aid in the differential diagnosis of AD. Findings support the view that the STMB may be a suitable cognitive marker for AD.
  • article 3 Citação(ões) na Scopus
    Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization
    (2023) CRIVELLI, Lucia; CALANDRI, Ismael Luis; SUEMOTO, Claudia Kimie; SALINAS, Rosa Maria; VELILLA, Lina Marcela; YASSUDA, Monica Sanches; CARAMELLI, Paulo; LOPERA, Francisco; NITRINI, Ricardo; SEVLEVER, Gustavo Emilio; SOSA, Ana Luisa; ACOSTA, Daisy; BAIETTI, Ana Maria Charamelo; CUSICANQUI, Maria Isabel; CUSTODIO, Nilton; SIMONE, Sergio Dansilio De; DERIO, Carolina Delgado; DUQUE-PENAILILLO, Lissette; DURAN, Juan Carlos; JIMENEZ-VELAZQUEZ, Ivonne Z.; LEON-SALAS, Jorge Mario; BERGAMO, Yanina; CLARENS, Maria Florencia; DAMIAN, Andres; DEMEY, Ignacio; HELOU, Maria Belen; MARQUEZ, Carlos; MARTIN, Maria Eugenia; MARTIN, Maria da Graca Morais; QUERZE, Diego; SURACE, Ezequiel Ignacio; ACOSTA-EGEA, Sabrina; AGUIRRE-SALVADOR, Esteban; SOUZA, Leonardo Cruz de; CANCADO, Gustavo Henrique da Cunha Peixoto; BRUCKI, Sonia Maria Dozzi; FRIEDLAENDER, Clarisse Vasconcelos; GOMES, Karina Braga; GUTIERREZ, Myriam; RIOS, Carlos Laforcada; GALINDO, Joyce Graciela Martinez; MONTESINOS, Rosa; NUNEZ-HERRERA, Alberto; OSPINA-HENAO, Sebastian; RODRIGUEZ, Guillermina; MASSON, Victoria Ruiz; SANCHEZ, Monica; SCHENK, Christian E.; SOTO, Ligia; BARBOSA, Maira Tonidandel; TOSATTI, Jessica Abdo Goncalves; VICUNA, Yosselin; ESPELAND, Mark; HAKANSSON, Krister; KIVIPELTO, Miia; BAKER, Laura; SNYDER, Heather; CARRILLO, Maria; ALLEGRI, Ricardo Francisco
    INTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.
  • article 13 Citação(ões) na Scopus
    Working Group Recommendations for the Practice of Teleneuropsychology in Latin America
    (2022) CRIVELLI, Lucia; QUIROZ, Yakeel T.; CALANDRI, Ismael L.; MARTIN, Maria E.; VELILLA, Lina M.; I, Maria Cusicanqui; YGLESIAS, Fernando Coto; LLIBRE-RODRIGUEZ, Juan J.; ARMELE, Monserrat; ROMAN, Fabian; BARCELO, Ernesto; DECHENT, Claudia; CARELLO, Maria Agostina; OLAVARRIA, Loreto; YASSUDA, Monica S.; CUSTODIO, Nilton; DANSILIO, Sergio; SOSA, Ana L.; ACOSTA, Daisy M.; BRUCKI, Sonia M. D.; CARAMELLI, Paulo; SLACHEVSKY, Andrea; NITRINI, Ricardo; CARRILLO, Maria C.; ALLEGRI, Ricardo F.
    Objective Teleneuropsychology (teleNP) could potentially expand access to services for patients who are confined, have limited personal access to healthcare, or live in remote areas. The emergence of the COVID-19 pandemic has significantly increased the use of teleNP for cognitive assessments. The main objective of these recommendations is to identify which procedures can be potentially best adapted to the practice of teleNP in Latin America, and thereby facilitate professional decision-making in the region. Method Steps taken to develop these recommendations included (1) formation of an international working group with representatives from 12 Latin American countries; (2) assessment of rationale, scope, and objectives; (3) formulation of clinical questions; (4) evidence search and selection; (5) evaluation of existing evidence and summary; and (6) formulation of recommendations. Levels of evidence were graded following the Oxford Centre for Evidence-Based Medicine system. Databases examined included PubMed, WHO-IRIS, WHO and PAHO-IRIS, indice Bibliografico Espanol en Ciencias de la Salud (IBCS), and LILACS. Results Working group members reviewed 18,400 titles and 422 abstracts and identified 19 articles meeting the criteria for level of evidence, categorization, and elaboration of recommendations. The vast majority of the literature included teleNP tests in the English language. The working group proposed a series of recommendations that can be potentially best adapted to the practice of teleNP in Latin America. Conclusions There is currently sufficient evidence to support the use of videoconferencing technology for remote neuropsychological assessments. These recommendations will likely contribute to the advancement of teleNP research and practice in the region.
  • article 23 Citação(ões) na Scopus
    The impact of COVID-19 on the well-being and cognition of older adults living in the United States and Latin America
    (2021) BABULAL, Ganesh M.; TORRES, Valeria L.; ACOSTA, Daisy; AGUERO, Cinthya; AGUILAR-NAVARRO, Sara; AMARIGLIO, Rebecca; USSUI, Juliana Aya; BAENA, Ana; BOCANEGRA, Yamile; BRUCKI, Sonia Maria Dozzi; BUSTIN, Julian; CABRERA, Diego M.; CUSTODIO, Nilton; DIAZ, Monica M.; PENAILILLO, Lissette Duque; FRANCO, Idalid; GATCHEL, Jennifer R.; GARZA-NAVEDA, Ana Paola; LARA, Mariana Gonzalez; GUTIERREZ-GUTIERREZ, Lidia; GUZMAN-VELEZ, Edmarie; HANSEEUW, Bernard J.; JIMENEZ-VELAZQUEZ, Ivonne Z.; RODRIGUEZ, Tomas Leon; LLIBRE-GUERRA, Jorge; MARQUINE, Maria J.; MARTINEZ, Jairo; MEDINA, Luis D.; MIRANDA-CASTILLO, Claudia; PAREDES, Alejandra Morlett; MUNERA, Diana; NUNEZ-HERRERA, Alberto; OLIVEIRA, Maira Okada de; PALMER-CANCEL, Santiago J.; PARDILLA-DELGADO, Enmanuelle; PERALES-PUCHALT, Jaime; PLUIM, Celina; RAMIREZ-GOMEZ, Liliana; RENTZ, Dorene M.; RIVERA-FERNANDEZ, Claudia; ROSSELLI, Monica; SERRANO, Cecilia M.; SUING-ORTEGA, Maria Jose; SLACHEVSKY, Andrea; SOTO-ANARI, Marcio; SPERLING, Reisa A.; TORRENTE, Fernando; THUMALA, Daniela; VANNINI, Patrizia; VILA-CASTELAR, Clara; YANEZ-ESCALANTE, Tatiana; QUIROZ, Yakeel T.
    Background: In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic's impact on the well-being and cognition of older adults living in the United States (US), Argentina, Chile, Mexico, and Peru. Methods: 1,608 (646 White, 852 Latino, 77 Black, 33 Asian; 72% female) individuals from the US and four Latin American countries aged >= 55 years completed an online survey regarding well-being and cognition during the pandemic between May and September 2020. Outcome variables (pandemic impact, discrimination, loneliness, purpose of life, subjective cognitive concerns) were compared across four US ethnoracial groups and older adults living in Argentina, Chile, Mexico, and Peru. Findings: Mean age for all participants was 66.7 (SD = 7.7) years and mean education was 15.4 (SD = 2.7) years. Compared to Whites, Latinos living in the US reported greater economic impact (p < .001, eta(2)(p) = 0.031); while Blacks reported experiencing discrimination more often (p< 001, eta(2)(p) = 0.050).
  • article 6 Citação(ões) na Scopus
    Profiles of cognitive impairment in the continuum from normal cognition to Alzheimer's clinical syndrome: Contributions of the short-term memory binding tests
    (2020) CECCHINI, Mario Amore; FOSS, Maria Paula; TUMAS, Vitor; PATROCINIO, Flavia A. P.; CHIARI-CORREIA, Rodolfo D.; NOVARETTI, Nathalia; BROZINGA, Tamara R.; BAHIA, Valeria Santoro; SOUZA, Leonardo Cruz de; GUIMARAES, Henrique Cerqueira; CARAMELLI, Paulo; LIMA-SILVA, Thais Bento; CASSIMIRO, Luciana; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; SALA, Sergio Della; PARRA, Mario A.; YASSUDA, Monica Sanches
    Background Short-term memory binding (STMB) tests assess conjunctive binding, in which participants should remember the integration of features, such as shapes (or objects) and colors, forming a unique representation in memory. In this study, we investigated two STMB paradigms: change detection (CD) and free recall (FR). Objective To investigate the cognitive profile in the CD and FR tasks of three diagnostic groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS). In addition, we aimed to calculate and compare the accuracy of the CD and FR tasks to identify MCI and ACS. Methods Participants were 24 CU, 24 MCI, and 37 ACS. The cognitive scores of the clinical groups were compared using analysis of variance (ANOVA) and receiver-operating characteristic (ROC) analyses were carried out to verify the accuracy of the STMB tasks. Results In the CD task, CU was different from MCI and ACS (CU > MCI = ACS), while in the FR task all groups were different (CU > MCI > ACS). The ROC analyses showed an area under the curve (AUC) of 0.855 comparing CU with MCI for the CD task and 0.975 for the FR. The AUC comparing CU and ACS was 0.924 for the CD and 0.973 for the FR task. The FR task showed better accuracy to identify MCI patients, and the same accuracy to detect ACS. Conclusion The present findings indicate that impairments in CD and FR of bound representations are features of the cognitive profiles of MCI and ACS patients.
  • article 67 Citação(ões) na Scopus
    Dementia in Latin America: Paving the way toward a regional action plan
    (2021) PARRA, Mario Alfredo; BAEZ, Sandra; SEDENO, Lucas; CAMPO, Cecilia Gonzalez; SANTAMARIA-GARCIA, Hernando; APRAHAMIAN, Ivan; BERTOLUCCI, Paulo H. F.; BUSTIN, Julian; BICALHO, Maria Aparecida Camargos; CANO-GUTIERREZ, Carlos; CARAMELLI, Paulo; CHAVES, Marcia L. F.; COGRAM, Patricia; BEBER, Barbara Costa; COURT, Felipe A.; SOUZA, Leonardo Cruz de; CUSTODIO, Nilton; DAMIAN, Andres; CRUZ, Myriam de la; RODRIGUEZ, Roberta Diehl; BRUCKI, Sonia Maria Dozzi; FAJERSZTAJN, Lais; FARIAS, Gonzalo A.; FELICE, Fernanda G. De; FERRARI, Raffaele; OLIVEIRA, Fabricio Ferreira de; FERREIRA, Sergio T.; FERRETTI, Ceres; BALTHAZAR, Marcio Luiz Figueredo; FROTA, Norberto Anizio Ferreira; FUENTES, Patricio; GARCIA, Adolfo M.; GARCIA, Patricia J.; PORTO, Fabio Henrique de Gobbi; PENAILILLO, Lissette Duque; ENGLER, Henry Willy; MAIER, Irene; MATA, Ignacio F.; GONZALEZ-BILLAULT, Christian; LOPEZ, Oscar L.; MORELLI, Laura; NITRINI, Ricardo; QUIROZ, Yakeel T.; BARRAGAN, Alejandra Guerrero; HUEPE, David; PIO, Fabricio Joao; SUEMOTO, Claudia Kimie; KOCHHANN, Renata; KOCHEN, Silvia; KUMFOR, Fiona; LANATA, Serggio; MILLER, Bruce; MANSUR, Leticia Lessa; HOSOGI, Mirna Lie; LILLO, Patricia; GUERRA, Jorge Llibre; LIRA, David; LOPERA, Francisco; COMAS, Adelina; AVILA-FUNES, Jose Alberto; SOSA, Ana Luisa; RAMOS, Claudia; RESENDE, Elisa de Paula Franca; SNYDER, Heather M.; TARNANAS, Ioannis; YOKOYAMA, Jenifer; LLIBRE, Juan; CARDONA, Juan Felipe; POSSIN, Kate; KOSIK, Kenneth S.; MONTESINOS, Rosa; MOGUILNER, Sebastian; SOLIS, Patricia Cristina Lourdes; FERRETTI-REBUSTINI, Renata Eloah de Lucena; RAMIREZ, Jeronimo Martin; MATALLANA, Diana; MBAKILE-MAHLANZA, Lingani; TON, Alyne Mendonca Marques; TAVARES, Ronnielly Melo; MIOTTO, Eliane C.; MUNIZ-TERRERA, Graciela; MUNOZ-NEVAREZ, Luis Arnoldo; OROZCO, David; OLIVEIRA, Maira Okada de; PIGUET, Olivier; CAIPA, Maritza Pintado; ESCUDERO, Stefanie Danielle Pina; SCHILLING, Lucas Porcello; PALMEIRA, Andre Luiz Rodrigues; YASSUDA, Monica Sanches; SANTACRUZ-ESCUDERO, Jose Manuel; SERAFIM, Rodrigo Bernardo; SMID, Jerusa; SLACHEVSKY, Andrea; SERRANO, Cecilia; SOTO-ANARI, Marcio; TAKADA, Leonel Tadao; GRINBERG, Lea Tenenholz; TEIXEIRA, Antonio Lucio; BARBOSA, Maira Tonidandel; TREPEL, Dominic; IBANEZ, Agustin
    Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
  • article 256 Citação(ões) na Scopus
    World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
    (2020) KIVIPELTO, Miia; MANGIALASCHE, Francesca; SNYDER, Heather M.; ALLEGRI, Ricardo; ANDRIEU, Sandrine; ARAI, Hidenori; BAKER, Laura; BELLEVILLE, Sylvie; BRODATY, Henry; BRUCKI, Sonia M.; CALANDRI, Ismael; CARAMELLI, Paulo; CHEN, Christopher; CHERTKOW, Howard; CHEW, Effie; CHOI, Seong H.; CHOWDHARY, Neerja; CRIVELLI, Lucia; TORRE, Rafael De La; DU, Yifeng; DUA, Tarun; ESPELAND, Mark; FELDMAN, Howard H.; HARTMANIS, Maris; HARTMANN, Tobias; HEFFERNAN, Megan; HENRY, Christiani J.; HONG, Chang H.; HAKANSSON, Krister; IWATSUBO, Takeshi; JEONG, Jee H.; JIMENEZ-MAGGIORA, Gustavo; KOO, Edward H.; LAUNER, Lenore J.; LEHTISALO, Jenni; LOPERA, Francisco; MARTINEZ-LAGE, Pablo; MARTINS, Ralph; MIDDLETON, Lefkos; MOLINUEVO, Jose L.; MONTERO-ODASSO, Manuel; MOON, So Y.; MORALES-PEREZ, Kristal; NITRINI, Ricardo; NYGAARD, Haakon B.; PARK, Yoo K.; PELTONEN, Markku; QIU, Chengxuan; QUIROZ, Yakeel T.; RAMAN, Rema; RAO, Naren; RAVINDRANATH, Vijayalakshmi; ROSENBERG, Anna; SAKURAI, Takashi; SALINAS, Rosa M.; SCHELTENS, Philip; SEVLEVER, Gustavo; SOININEN, Hilkka; SOSA, Ana L.; SUEMOTO, Claudia K.; TAINTA-CUEZVA, Mikel; VELILLA, Lina; WANG, Yongxiang; WHITMER, Rachel; XU, Xin; BAIN, Lisa J.; SOLOMON, Alina; NGANDU, Tiia; CARRILLO, Maria C.
    Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
  • article 48 Citação(ões) na Scopus
    The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science
    (2021) IBANEZ, Agustin; YOKOYAMA, Jennifer S.; POSSIN, Katherine L.; MATALLANA, Diana; LOPERA, Francisco; NITRINI, Ricardo; TAKADA, Leonel T.; CUSTODIO, Nilton; ORTIZ, Ana Luisa Sosa; AVILA-FUNES, Jose Alberto; BEHRENS, Maria Isabel; SLACHEVSKY, Andrea; MYERS, Richard M.; COCHRAN, J. Nicholas; BRUSCO, Luis Ignacio; BRUNO, Martin A.; BRUCKI, Sonia M. D.; PINA-ESCUDERO, Stefanie Danielle; OLIVEIRA, Maira Okada de; KEHOE, Patricio Donnelly; GARCIA, Adolfo M.; CARDONA, Juan Felipe; SANTAMARIA-GARCIA, Hernando; MOGUILNER, Sebastian; DURAN-ANIOTZ, Claudia; TAGLIAZUCCHI, Enzo; MAITO, Marcelo; IBARROLA, Erika Mariana Longoria; PINTADO-CAIPA, Maritza; GODOY, Maria Eugenia; BAKMAN, Vera; JAVANDEL, Shireen; KOSIK, Kenneth S.; VALCOUR, Victor; MILLER, Bruce L.
    Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.
  • article 18 Citação(ões) na Scopus
    The power of knowledge about dementia in Latin America across health professionals working on aging
    (2020) IBANEZ, Agustin; FLICHTENTREI, Daniel; HESSE, Eugenia; DOTTORI, Martin; TOMIO, Ailin; SLACHEVSKY, Andrea; SERRANO, Cecilia M.; GONZALEZ-BILLAUT, Christian; CUSTODIO, Nilton; MIRANDA, Claudia; BUSTIN, Julian; CETCKOVITCH, Marcelo; TORRENTE, Fernando; OLAVARRIA, Loreto; LEON, Tomas; BEBER, Barbara Costa; BRUKI, Sonia; SUEMOTO, Claudia K.; NITRINI, Ricardo; MILLER, Bruce L.; YOKOYAMA, Jennifer S.
    Introduction: Expert knowledge is critical to fight dementia in inequitable regions like Latin American and Caribbean countries (LACs). However, the opinions of aging experts on public policies' accessibility and transmission, stigma, diagnostic manuals, data-sharing platforms, and use of behavioral insights (BIs) are not well known. Methods: We investigated opinions among health professionals working on aging in LACs (N = 3365) with regression models including expertise-related information (public policies, BI), individual differences (work, age, academic degree), and location. Results: Experts specified low public policy knowledge (X-2 = 41.27, P < .001), high levels of stigma (X-2 = 2636.37, P < .001), almost absent BI knowledge (X-2 = 56.58, P < .001), and needs for regional diagnostic manuals (X-2 = 2893.63, df = 3, P < .001) and data-sharing platforms (X-2 = 1267.5, df = 3, P < .001). Lack of dementia knowledge was modulated by different factors. An implemented BI-based treatment for a proposed prevention program improved perception across experts. Discussion: Our findings help to prioritize future potential actions of governmental agencies and non-governmental organizations (NGOs) to improve LACs' dementia knowledge.
  • article 0 Citação(ões) na Scopus
    A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America
    (2023) LOPERA, Francisco; CUSTODIO, Nilton; RICO-RESTREPO, Mariana; ALLEGRI, Ricardo F.; BARRIENTOS, Jose Domingo; BATRES, Estuardo Garcia; CALANDRI, Ismael L.; MOSCOSO, Cristian Calero; CARAMELLI, Paulo; QUIROZ, Juan Carlos Duran; JANSEN, Angela Marie; ALVARADO, Alberto Jose Mimenza; NITRINI, Ricardo; PARODI, Jose F.; RAMOS, Claudia; SLACHEVSKY, Andrea; BRUCKI, Sonia Maria Dozzi
    Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for AD within and among nations. The region has varied geographic, ethnic, cultural, and economic conditions, which create unique challenges to AD diagnosis and management. To address these issues, the Americas Health Foundation convened a panel of eight neurologists, geriatricians, and psychiatrists from Argentina, Brazil, Colombia, Ecuador, Guatemala, Mexico, and Peru who are experts in AD for a three-day virtual meeting to discuss best practices for AD diagnosis and treatment in LAC and create a manuscript offering recommendations to address identified barriers. In LAC, several barriers hamper diagnosing and treating people with dementia. These barriers include access to healthcare, fragmented healthcare systems, limited research funding, unstandardized diagnosis and treatment, genetic heterogeneity, and varying social determinants of health. Additional training for physicians and other healthcare workers at the primary care level, region-specific or adequately adapted cognitive tests, increased public healthcare insurance coverage of testing and treatment, and dedicated search strategies to detect populations with gene variants associated with AD are among the recommendations to improve the landscape of AD.