CAMILA MOTTA VENCHIARUTTI MONIZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
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- Biomarkers in Anal Cancer: Current Status in Diagnosis, Disease Progression and Therapeutic Strategies(2022) MATHIAS-MACHADO, Maria Cecilia; PEIXOTO, Renata D'Alpino; MONIZ, Camila Motta Venchiarutti; JACOME, Alexandre A.Squamous cell carcinoma of the anal canal (SCCA) is a rare neoplasm, but with rising incidence rates in the past few decades; it is etiologically linked with the human papillomavirus (HPV) infection and is especially prevalent in immunocompromised patients, mainly those infected with HIV. Fluoropyrimidine-based chemoradiotherapy remains the cornerstone of the treatment of non-metastatic disease, but the locally advanced disease still presents high rates of disease recurrence and systemic therapy of SCCA is an unmet clinical need. Despite sharing common molecular aspects with other HPV-related malignancies, such as cervical and head and neck cancers, SCCA presents specific epigenomic, genomic, and transcriptomic abnormalities, which suggest that genome-guided personalized therapies should be specifically designed for this disease. Actionable mutations are rare in SCCA and immune checkpoint inhibition has not yet been proven useful in an unselected population of patients. Therefore, advances in systemic therapy of SCCA will only be possible with the identification of predictive biomarkers and the subsequent development of targeted therapies or immunotherapeutic approaches that consider the unique tumor microenvironment and the intra- and inter-tumoral heterogeneity. In the present review, we address the molecular characterization of SCCA and discuss potential diagnostic, predictive and prognostic biomarkers of this complex and challenging disease.
bookPart Prevenção primária e secundária(2022) NEVES, Willian das; MONIZ, Camila Motta Venchiarutti; HOFF, Paulo Marcelo Gehm- HIV impact in localized anal carcinoma: A matched cohort study(2022) ALMEIDA, A. Acioli De; ROCHA, E.; BONADIO, R. Colombo; GALHERA, D.; BRAGHIROLI, M. I.; ALBAN, L. B.; VICTOR, C. R.; DORNELLAS, A. F. L.; SILVA, M. Polo Mingueti E; CARVALHO, C. S. Araujo De; BUENO, A.; NAHAS, C.; IBRAHIM, K.; CHEN, A.; HOFF, P. M.; MONIZ, C. Motta Venchiarutti