AKOTHIRENE CRISTHINA DUTRA BRISOLLA MARQUES
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conferenceObject Obstructive sleep apnea impairs insulin resistance in metabolic syndrome patients with normal levels of glucose(2016) CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson Cabral; TOSCHI-DIAS, Edgar; JORDAO, Camila Paixao; RONDON, Maria Urbana; ALVES, Maria Janieire N. N.; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani CredidioconferenceObject Diet and Exercise Training Improve Insulin-Glucose Metabolism and Sympathetic Hyperactivation in Obstructive Sleep Apnea and Metabolic Syndrome(2017) CEPEDA, Felipe X.; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; TOSCHI-DIAS, Edgar; RONDON, Maria Urbana P. B.; ALVES, Maria Janieire N. N.; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani C.- Arterial stiffness and its association with clustering of metabolic syndrome risk factors(2017) LOPES-VICENTE, Wanda R. P.; RODRIGUES, Sara; CEPEDA, Felipe X.; JORDAO, Camila Paixao; COSTA-HONG, Valeria; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; ALVES, Maria Janieire N. N.; BORTOLOTTO, Luiz A.; TROMBETTA, Ivani C.Background: Metabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However, the role played by clustering of risk factors and the combining pattern of MetS risk factors and their association with the arterial stiffness have yet to be fully understood. Age, hypertension and diabetes mellitus seem to be strongly associated with increased pulse wave velocity (PWV). This study aimed at determining the clustering and combining pattern of MetS risk factors and their association with the arterial stiffness in non-diabetic and non-hypertensive patients. Methods: Recently diagnosed and untreated patients with MetS (n = 64, 49 +/- 8 year, 32 +/- 4 kg/m(2)) were selected, according to ATP III criteria and compared to a control group (Control, n = 17, 49 +/- 6 year, 27 +/- 2 kg/m(2)). Arterial stiffness was evaluated by PWV in the carotid-femoral segment. Patients were categorized and analyzed according MetS risk factors clustering (3, 4 and 5 factors) and its combinations. Results: Patients with MetS had increased PWV when compared to Control (7.8 +/- 1.1 vs. 7.0 +/- 0.5 m/s, p < 0.001). In multivariate analysis, the variables that remained as predictors of PWV were age (beta = 0.450, p < 0.001), systolic blood pressure (beta = 0.211, p = 0.023) and triglycerides (beta = 0.212, p = 0.037). The increased number of risk factors reflected in a progressive increase in PWV. When adjusted to systolic blood pressure, PWV was greater in the group with 5 risk factors when compared to the group with 3 risk factors and Control (8.5 +/- 0.4 vs. 7.5 +/- 0.2, p = 0.011 and 7.2 +/- 0.3 m/s, p = 0.012). Similarly, the 4 risk factors group had higher PWV than the Control (7.9 +/- 0.2 vs. 7.2 +/- 0.3, p = 0.047). Conclusions: The number of risk factors seems to increase arterial stiffness. Notably, besides age and increased systolic blood pressure, alterations in the triglycerides worsened the stiffness of large vessels, emphasizing the importance in addressing this risk factor in MetS patients.
conferenceObject Insulin Resistance Impairs Arterial Stiffness and Peripheral Vascular Resistance in Metabolic Syndrome Patients(2015) RODRIGUES, Sara; CEPEDA, Felipe; DUTRA-MARQUES, Akothirene; CARVALHO, Jefferson; TOSCHI-DIAS, Edgar; MAKI-NUNES, Cristiane; BORTOLOTTO, Luiz; COSTA-HONG, Valeria; RONDON, Maria; ALVES, Maria; NEGRAO, Carlos; TOMBETTA, IvaniconferenceObject Berlin Questionnaire is a Useful Tool to Identify Risk of Obstructive Sleep Apnea in Metabolic Syndrome Patients(2017) CEPEDA, Felipe Xerez; VIRMONDES, Leslie; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; TOSCHI-DIAS, Edgar; ALVES, Maria Janieire N. N.; RONDON, Maria Urbana P. B.; LOPES-VICENTE, Wanda R. P.; HUSSID, Maria Fernanda; LORENZI-FILHO, Geraldo; TROMBETTA, Ivani C.conferenceObject Oxygen uptake efficiency slope in patients with metabolic syndrome and obstructive sleep apnea(2016) CARVALHO, Jefferson Cabral; CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene Cristhina Brisolla; TOSCHI-DIAS, Edgar; RONDON, Maria Urbana Pinto Brandao; ALVES, Maria-Janieire Nazare Nunes; BRAGA, Ana Maria Fonseca Wanderley; LORENZI-FILHO, Gerald; TROMBETTA, Ivani CredidioconferenceObject Diet Associated with Exercise Training Improves Heart Rate Recovery and Autonomic Control in Metabolic Syndrome Subjects(2018) CEPEDA, Felipe Xerez; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; TOSCHI-DIAS, Edgar; CARVALHO, Jefferson C.; CARVALHO, Glauce L.; RONDON, Maria Urbana P. B.; ALVES, Maria Janieire N. N.; TROMBETTA, Ivani C.- The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome(2017) RODRIGUES, Sara; CEPEDA, Felipe X.; TOSCHI-DIAS, Edgar; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; COSTA-HONG, Valeria; ALVES, Maria Janieire N. N.; RONDON, Maria Urbana P. B.; BORTOLOTTO, Luiz A.; TROMBETTA, Ivani C.Metabolic syndrome (MetS) causes autonomic alteration and vascular dysfunction. The authors investigated whether impaired fasting glucose (IFG) is the main cause of vascular dysfunction via elevated sympathetic tone in nondiabetic patients with MetS. Pulse wave velocity, muscle sympathetic nerve activity (MSNA), and forearm vascular resistance was measured in patients with MetS divided according to fasting glucose levels: (1) MetS+IFG (blood glucose 100mg/dL) and (2) MetS-IFG (<100mg/dL) compared with healthy controls. Patients with MetS+IFG had higher pulse wave velocity than patients with MetS-IFG and controls (median 8.0 [interquartile range, 7.2-8.6], 7.3 [interquartile range, 6.9-7.9], and 6.9 [interquartile range, 6.6-7.2] m/s, P=.001). Patients with MetS+IFG had higher MSNA than patients with MetS-IFG and controls, and patients with MetS-IFG had higher MSNA than controls (31 +/- 1, 26 +/- 1, and 19 +/- 1 bursts per minute; P<.001). Patients with MetS+IFG were similar to patients with MetS-IFG but had higher forearm vascular resistance than controls (P=.008). IFG was the only predictor variable of MSNA. MSNA was associated with pulse wave velocity (R=.39, P=.002) and forearm vascular resistance (R=.30, P=.034). In patients with MetS, increased plasma glucose levels leads to an adrenergic burden that can explain vascular dysfunction.
conferenceObject Clustering and combining pattern of metabolic syndrome risk factors and its association with arterial stiffness(2016) VICENTE, Wanda Rafaela; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene C. B.; CARVALHO, Jefferson C.; JORDAO, Camila P.; TOSCHI-DIAS, Edgar; HUSSID, Maria Fernanda; COSTA-HONG, Valeria; BORTOLOTTO, Luiz A.; CEPEDA, Felipe X.; TROMBETTA, Ivani CredidioconferenceObject Metabolic efficiency during exercise in patients with overlap of obstructive sleep apnea in metabolic syndrome(2015) CARVALHO, Jefferson; CEPEDA, Felipe; TOSCHI-DIAS, Edgar; RODRIGUES, Sara; DUTRA-MARQUES, Akothirene; MAKI-NUNES, Cristiane; RONDON, Maria Urbana; ALVES, Maria Janiere; BRAGA, Ana Maria; FILHO, Geraldo; NEGRAO, Carlos; TROMBETTA, Ivani