OCTAVIO GRECCO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Low bone mineral density and muscle mass in common variable immunodeficiency patients: Association with CD4+T cells and B cells(2019) BARROS, M. Toledo; MELO, D. Barreto De; PEREIRA, R. M. Rodrigues; SINI, B.; COUTINHO, E. M.; TAKAYAMA, L.; KOKRON, C. M.; MARINHO, A. K.; GRECCO, O.; KALIL, J.; ANTILA, H. G.conferenceObject Mortality in a cohort of common variable immunodeficiency (CVID) patients from 1980 to 2019(2020) BARROS, M. T.; MARINHO, A. K. B. B.; SINI, B.; GRECCO, O.; KALIL, J.; KOKRON, C. M.- Bone Mineral Density is Related to CD4+ T Cell Counts and Muscle Mass is Associated with B Cells in Common Variable Immunodeficiency Patients(2024) MELO, Daniel Barreto de; PEREIRA, Rosa Maria Rodrigues; SINI, Bruno; LEVY, Debora; TAKAYAMA, Lilian; KOKRON, Cristina Maria; MARINHO, Ana Karolina Berselli; GRECCO, Octavio; KALIL FILHO, Jorge Elias; BARROS, Myrthes ToledoBackground: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by chronic/recurrent respiratory infections, bronchiectasis, autoimmunity, inflammatory, gastrointestinal diseases and malignancies associated with a chronic inflammatory state and increased risk of osteoporosis and muscle loss. Aim: The aim of this study was to evaluate bone mineral density (BMD), body composition and their relationship with lymphocyte subpopulations in CVID patients. Methods: Dual-energy X-ray absorptiometry was performed to assess BMD, lean mass, and fat mass in CVID patients. Peripheral blood CD4(+), CD8(+), and CD19(+) cells were measured using flow cytometry. Results: Thirty-three patients (37.3 +/- 10.8 years old) were examined. Although only 11.8% of the individuals were malnourished (BMI <18.5 kg/m(2)), 27.7% of them had low skeletal muscle mass index (SMI), and 57.6% of them had low BMD. Patients with osteopenia/osteoporosis presented lower weight (p = 0.007), lean mass (p = 0.011), appendicular lean mass (p = 0.011), SMI (p = 0.017), and CD4+ count (p = 0.030). Regression models showed a positive association between CD4+ count and bone/muscle parameters, whereas CD19+ B cell count was only associated with muscle variables. Analysis of ROC curves indicated a cutoff value of CD4+ count (657 cells/mm3; AUC: 0.71, 95% CI 0.52-0.90) which was related to low BMD. Weight (p = 0.004), lean mass (p = 0.027), appendicular lean mass (p = 0.022), SMI (p = 0.029), total bone mineral content (p = 0.005), lumbar (p = 0.005), femoral neck (p = 0.035), and total hip BMD (p<0.001) were found to be lower in patients with CD4+ count below the cutoff. Conclusion: CVID patients presented with low BMD, which was associated with CD4+ count. Moreover, low muscle parameters were correlated with B cell count.
conferenceObject Thrombosis Association with Administration of Intravenous Human Immunoglobulin in Patients with Primary or Secondary Immunodeficiencies(2017) GONCALVES, Danilo Gois; ASSIS, Joao Paulo de; SINI, Bruno; MARINHO, Ana Karolina; KOKRON, Cristina Maria; GRECCO, Octavio; KALIL, Jorge; BARROS, Myrthes ToledoconferenceObject Is the incidence of gastric tumor increasing in variable common immunodeficiency patients?(2019) GRECCO, O.; BARBUTI, R. C.; KOKRON, C. M.; MARINHO, A. K. B.; SINI, B. C.; FIGUEIRA, R. C. L.; KALIL, J.; BARROS, M. T.