SILVIA MOREIRA AYUB FERREIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Exercise training improves ambulatory blood pressure but not arterial stiffness in heart transplant recipients(2015) PASCOALINO, Lucas Nobilo; CIOLAC, Emmanuel Gomes; TAVARES, Aline Cristina; CASTRO, Rafael Ertner; AYUB-FERREIRA, Silvia Moreira; BACAL, Fernando; ISSA, Victor Sarli; BOCCHI, Edimar Alcides; GUIMARAES, Guilherme VeigaBACKGROUND: Hypertension is the most prevalent comorbidity after heart transplantation (HT). Exercise training (ET) is widely recommended as a key non-pharmacologic intervention for the prevention and management of hypertension, but its effects on ambulatory blood pressure (ABP) and some mechanisms involved in the pathophysiology of hypertension have not been studied in this population. The primary purpose of this study was to investigate the effects of ET on ABP and arterial stiffness of HT recipients. METHODS: 40 HT patients, randomized to ET (n = 31) or a control group (n = 9) underwent a maximal graded exercise test, 24-hour ABP monitoring, and carotid-femoral pulse wave velocity (PWV) assessment before the intervention and at a 12-week follow-up assessment. The ET program was performed thrice-weekly and consisted primarily of endurance exercise (40 minutes) at similar to 70% of maximum oxygen uptake (Vo(2MAX)) RESULTS: The ET group had reduced 24-hour (4.0 +/- 1.4 mm Hg, p < 0.01) and daytime (4.8 +/- 1.6 mm Hg, p < 0.01) systolic ABP, and 24-hour (7.0 +/- 1.4 mm Hg, p < 0.001) daytime (7.5 +/- 1.6 mm Hg, p < 0.001) and nighttime (5.9 +/- 1.5 mm Hg, p < 0.001) diastolic ABP after the intervention. The ET group also had improved Vo(2MAX) (9.7% +/- 2.6%, p < 0.001) after the intervention. However, PWV did not change after ET. No variable was changed in the control group after the intervention. CONCLUSIONS: The 12-week ET program was effective for reducing ABP but not PWV in heart transplant recipients. This result suggesfs that endurance ET may be a tool to counteract hypertension in this high-risk population.
conferenceObject Therapeutical Implications of Clinical Characteristics of Patients With Chagas Cardiomyopathy and Decompensated Heart Failure(2015) ISSA, V. S.; LIMA, G. C.; AYUB-FERREIRA, S. M.; LAGE, S. G.; OLIVEIRA JR., M. T.; NICOLAU, J.; BOCCHI, E. A.conferenceObject Carotid Endarterectomy Prior to Ventricular Assist Device Placement in a Patient with Cardiogenic Shock(2022) LIRA, M. S.; DANTAS, R. C.; BELFORT, D. d.; FURQUIM, S. R.; ARAGAO, C. A.; GOMES, B. R.; BISELLI, B. S.; FERREIRA, S. M.; BOCCHI, E. A.- Control of sinus tachycardia as an additional therapy in patients with decompensated heart failure (CONSTATHE-DHF): A randomized, double-blind, placebo-controlled trial(2016) LOFRANO-ALVES, Marco Stephan; ISSA, Victor Sarli; BISELLI, Bruno; CHIZZOLA, Paulo; AYUB-FERREIRA, Silvia Moreira; BOCCHI, Edimar Alcides
conferenceObject COVID-19 Complicating Perioperative Management of Left Ventricular Assist Device Implantation(2021) BELFORT, D. S.; BISELLI, B.; BRANDAO, S. M.; GOMES, B. R.; LIRA, M. S.; DANTAS, R. C.; ARAGAO, C. A.; GALAS, F. R.; GAIOTTO, F. A.; JATENE, F. B.; BOCCHI, E. A.; FERREIRA, S. M.conferenceObject Study of Necropsies of Patients Submitted to Heart Transplantation: NEHTS-NecropsyHeartTransplantationStudy(2012) AYUB-FERREIRA, S. M.; VALETTE, T. N.; BENVENUTI, L. A.; BOCCHI, E. A.Purpose: Autopsy has been considered the gold standard for diagnosing the cause of death. Discrepancies between pre and post-mortem diagnosis continue to be reported, ranging from 4.1 to 49.8% of cases referred for autopsy examination. Methods and Materials: Retrospective study. It was included all autopsies of heart transplanted patients performed between 2000-2010. Clinical data of patients, medical cause of death and cause of death at autopsy were analyzed. Then pre-mortem diagnosis was confronted with the cause ofdeath at necropsy according to the criteria of Goldman et al. (N Engl J Med 1983;308:1000.) Results: 48 autopsies were analyzed; 29 (60.4%) had a nondiscrepant diagnosis, 16 (33.3%) had a discrepant diagnosis and 3 (6.3%) had uncertain autopsy diagnosis. Among the discrepant diagnosis, 15 (31.3%) had possible impact on survival and 1 (2.1%) had no impact on survival. Among those pre-morten diagnoses associated with discrepancies, infection (31.3%) heads the list, followed by hyperacute rejection (18.8%), pulmonary thromboembolism (18.8%) and acute cellular rejection (18.8%). Conclusions: Even with advances in diagnostic technology, there are still differences between the clinical diagnosis and post-mortem findings. Furthermore, in most cases an accurate clinical diagnosis could led to a change in therapy and prolonged survival.conferenceObject Immunohistochemical Counting of Mononuclear Infiltrates in Endomyocardial Biopsy Fragments: A New Method To Improve the Diagnosis of Rejection after Heart Transplantation(2013) BOCCHI, E. A.; BENVENUTTI, L. A.; TANIGAWA, R.; BRANDAO, S.; ISSA, V. S.; AYUB-FERREIRA, S.; CRUZ, F.; POMERANTZEFF, P.; HONORATO, R.; LOURENCO-FILHO, D. D.; FIORELLI, A. I.; CHIZZOLA, P.; SOUZA, G.; BACAL, F.