MARIA CLAUDIA NOGUEIRA ZERBINI

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Departamento de Patologia, Faculdade de Medicina - Docente
LIM/14 - Laboratório de Investigação em Patologia Hepática, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 13
  • conferenceObject
    Gene and Protein Expression Analysis of GLUT1 and HK2 in Primary Macronodular Adrenocortical Hyperplasia with High 18F-FDG Uptake in PET/CT
    (2014) CAVALCANTE, Isadora Pontes; ALENCAR, Guilherme Asmar; MARIANI, Beatriz M. P.; MURAD, Andre Faria; ALMEIDA, Madson Q.; BUCHPIGUEL, Carlos Alberto; LERARIO, Antonio M.; ZERBINI, Maria Claudia N.; MENDONCA, Berenice B.; FRAGOSO, Maria Candida B. V.
  • bookPart
    Linfoma de Hodgkin
    (2014) MORAIS, José Carlos Oliveira de; ZERBINI, Maria Cláudia Nogueira
  • article 31 Citação(ões) na Scopus
    A microRNA signature profile in EBV+ diffuse large B-cell lymphoma of the elderly
    (2014) ANDRADE, Tathiana Azevedo de; EVANGELISTA, Adriane Feijo; CAMPOS, Antonio Hugo Froes; POLES, Wagner Augusto; BORGES, Natalia Morais; CAMILLO, Claudia Malheiros Coutinho; SOARES, Fernando Augusto; VASSALLO, Jose; PAES, Roberto Pinto; ZERBINI, Maria Claudia; SCAPULATEMPO, Cristovam; ALVES, Antonio Correa; YOUNG, Ken H.; COLLEONI, Gisele Wally Braga
    Currently, there is no characteristic microRNA (miRNA) expression pattern in Epstein-Barr virus(+) diffuse large B-cell lymphoma of the elderly (EBV(+)DLBCLe). This study aims to characterize a signature profile and identify miRNAs that can be used as biomarkers and alternative therapeutic targets for EBV(+)DLBCLe. Seventy-one DLBCL patients aged 50 years and older were included and four EBV+ and four EBV- samples were analyzed in two miRNA array platforms (pilot study). A larger multicenter cohort (29 EBV(+)DLBCLe and 65 EBV-DLBCL patients) was used to validate the results by real-time polymerase chain reaction. In the pilot study, 9% of DLBCL were EBV(+)DLBCLe by in situ hybridization. In multicenter study, EBV(+)w DLBCLe group showed a predominance of non-germinal center B-cell origin. Overall survival duration of EBV(+)DLBCLe was significantly inferior to that of EBV-DLBCL patients. We found 10 deregulated miRNAs in the two groups, but only seven were statistically different. We confirmed overexpression of hsa-miR-126, hsa-miR-146a, hsa-miR-146b, hsa-miR-150, and hsa-miR-222 and underexpression of hsa-miR-151 in EBV(+)DLBCLe cases compared to EBV-DLBCL cases. Hsa-miR-146b and hsa-miR-222 showed high specificity for identifying EBV(+)DLBCLe. The present study proposed a miRNA signature for EBV(+)DLBCLe and our findings suggest that hsa-miR-146b and hsa-miR-222 could be biomarkers and therapeutic targets.
  • conferenceObject
    Penetrance of TMEM127-related pheochromocytoma in a six-generation family
    (2014) TOLEDO, S. P. A.; LOURENCO JR., D. M.; SEKIYA, T.; LUCON, A. M.; BAENA, R. C.; CASTRO, C. C.; BORTOLOTTO, L. A.; ZERBINI, M. C. N.; SIQUEIRA, S. A. C.; TOLEDO, R. A.; DAHIA, P. L. M.
  • conferenceObject
    Nodal Peripheral T-Cell Lymphoma - a Clinical and Epidemiological Analysis at Medicine School of Sao Paulo University
    (2014) LAGE, Luis Alberto de Padua Covas; GONCALVES, Marianne Castro; SANTUCCI, Rodrigo; COSTA, Renata Oliveira; LEVY, Debora; ZERBINI, Maria Claudia; PEREIRA, Juliana
  • article 23 Citação(ões) na Scopus
    Autoimmune manifestations in SCID due to IL7R mutations: Omenn syndrome and cytopenias
    (2014) ZAGO, Claudia Augusta; JACOB, Cristina Miuki Abe; DINIZ, Edna Maria de Albuquerque; LOVISOLO, Silvana Maria; ZERBINI, Maria Claudia Nogueira; DORNA, Mayra; WATANABE, Leticia; FERNANDES, Juliana Folloni; ROCHA, Vanderson; OLIVEIRA, Joao Bosco; CARNEIRO-SAMPAIO, Magda
    B+NK+SCID (severe combined immunodeficiency) due to IL7R alpha deficiency represents approximately 10% of American SCID cases. To better understand the spectrum of autoimmune disorders associated with IL7R alpha deficiency, we describe two unrelated IL7R alpha-deficient female SCID infants whose clinical picture was dominated by autoimmune manifestations: one with intrauterine Omenn syndrome (OS) and another with persistent thrombocytopenic purpura since 4 months of age. The OS baby harbored a homozygous p.C118Y mutation in IL7R. She presented dense eosinophilic infiltrates in several organs, including pancarditis, which may have contributed to her death (on the 2nd day of life). B cells were observed in lymph nodes, spleen, bone marrow and thymus. The second patient harbored compound heterozygous p.01 8Y and p.I121NfsX8 mutations. She underwent a successful unrelated cord blood transplant. In conclusion, early OS can be observed in patients with IL7R mutations, and autoimmune cytopenias could also complicate the clinical course of SCID babies with this type of defect. (C) 2014 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
  • conferenceObject
    Dealing with Bone Marrow Specimen in Staging of Classical Hodgkin Lymphoma: An Old Issue Revisited in the ""FDG PET Era""
    (2014) PAULA, H. M. de; GONCALVES, M. C.; LINARDI, C. C. G.; BUCCHERI, V.; CERCI, J. J.; SIQUEIRA, S. A. C.; ALDRED, V. L.; ZERBINI, M. C. N.
  • article 1 Citação(ões) na Scopus
    Doença de Castleman multicêntrica não associada aos vírus HHV‐8 e HIV
    (2014) FORTESKI, Denise de Fatima; MACHADO NETTO, Fernanda Calil; LOMONTE, Andrea Barranjard Vannucci; ANJOS, Bruno Cesar Cavalcanti dos; ZERBINI, Maria Claudia Nogueira; ZERBINI, Cristiano Augusto de Freitas
    Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case.
  • conferenceObject
    Mutation and Expression Analysis of DICER1 and Mir-103 in Pediatric and Adult Adrenocortical Tumors
    (2014) SOUSA, Gabriela R. V.; RIBEIRO, Tamaya C.; FARIA, Andre M.; MARIANI, Beatriz M. P.; LERARIO, Antonio M.; ZERBINI, Maria Claudia N.; SOARES, Ibere C.; WAKAMATSU, Alda; ALVES, Venancio A. F.; MENDONCA, Berenice B.; FRAGOSO, Maria Candida B. V.; LATRONICO, Ana Claudia; ALMEIDA, Madson Q.
  • bookPart
    Tumores renais na infância
    (2014) ZERBINI, Maria Cláudia Nogueira; ALVES, Maria Teresa de Seixas; LIMA, Flávio de Oliveira