MARCELO DANTAS TAVARES DE MELO
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conferenceObject Biventricular imaging markers to predict outcome in non-compaction cardiomyopathy: a machine learning study(2018) ROCON, C.; TABASSIAN, M.; MELO, M. D. Tavares De; ARAUJO FILHO, J. A.; PARGA FILHO, J. R.; HAJJAR, L. A.; KALIL FILHO, R.; BOCCHI, E. A.; D'HOOGE, J.; SALEMI, V. M. C.- Biventricular imaging markers to predict outcomes in non-compaction cardiomyopathy: a machine learning study(2020) ROCON, Camila; TABASSIAN, Mahdi; MELO, Marcelo Dantas Tavares de; ARAUJO FILHO, Jose Arimateia de; GRUPI, Cesar Jose; PARGA FILHO, Jose Rodrigues; BOCCHI, Edimar Alcides; D'HOOGE, Jan; SALEMI, Vera Maria CuryAims Left ventricular non-compaction cardiomyopathy (LVNC) is a genetic heart disease, with heart failure, arrhythmias, and embolic events as main clinical manifestations. The goal of this study was to analyse a large set of echocardiographic (echo) and cardiac magnetic resonance imaging (CMRI) parameters using machine learning (ML) techniques to find imaging predictors of clinical outcomes in a long-term follow-up of LVNC patients. Methods and results Patients with echo and/or CMRI criteria of LVNC, followed from January 2011 to December 2017 in the heart failure section of a tertiary referral cardiologic hospital, were enrolled in a retrospective study. Two-dimensional colour Doppler echocardiography and subsequent CMRI were carried out. Twenty-four hour Holter monitoring was also performed in all patients. Death, cardiac transplantation, heart failure hospitalization, aborted sudden cardiac death, complex ventricular arrhythmias (sustained and non-sustained ventricular tachycardia), and embolisms (i.e. stroke, pulmonary thromboembolism and/or peripheral arterial embolism) were registered and were referred to as major adverse cardiovascular events (MACEs) in this study. Recruited for the study were 108 LVNC patients, aged 38.3 +/- 15.5 years, 48.1% men, diagnosed by echo and CMRI criteria. They were followed for 5.8 +/- 3.9 years, and MACEs were registered. CMRI and echo parameters were analysed via a supervised ML methodology. Forty-seven (43.5%) patients had at least one MACE. The best performance of imaging variables was achieved by combining four parameters: left ventricular (LV) ejection fraction (by CMRI), right ventricular (RV) end-systolic volume (by CMRI), RV systolic dysfunction (by echo), and RV lower diameter (by CMRI) with accuracy, sensitivity, and specificity rates of 75.5%, 77%, 75%, respectively. Conclusions Our findings show the importance of biventricular assessment to detect the severity of this cardiomyopathy and to plan for early clinical intervention. In addition, this study shows that even patients with normal LV function and negative late gadolinium enhancement had MACE. ML is a promising tool for analysing a large set of parameters to stratify and predict prognosis in LVNC patients.
- A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy(2021) MELO, Marcelo Dantas Tavares de; ARAUJO-FILHO, Jose de Arimateia Batista; BARBOSA, Jose Raimundo; ROCON, Camila; REGIS, Carlos Danilo Miranda; FELIX, Alex dos Santos; KALIL FILHO, Roberto; BOCCHI, Edimar Alcides; HAJJAR, Ludhmila Abrahao; TABASSIAN, Mahdi; D'HOOGE, Jan; SALEMI, Vera Maria CuryAims Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model. Methods and results Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8 +/- 14.8 years) were included. A comprehensive echocardiogram was performed. The layer-specific strain was analyzed from the apical two-, three, four-chamber views, short axis, and focused right ventricle views using 2D echocardiography (2DE) software. RBR was present in 44.9% of patients, and this group presented increased LV mass indexed (118 +/- 43.4 vs. 94.1 +/- 27.1g/m(2), P = 0.034), LV end-diastolic and end-systolic volumes (P < 0.001), E/e' (12.2 +/- 8.68 vs. 7.69 +/- 3.13, P = 0.034), and decreased LV ejection fraction (40.7 +/- 8.71 vs. 58.9 +/- 8.76%, P < 0.001) when compared to patients without RBR. Also, patients with RBR presented a significant decrease of global longitudinal, radial, and circumferential strain. When ML model based on a random forest algorithm and a neural network model was applied, it found that twist, NC/C, torsion, LV ejection fraction, and diastolic dysfunction are the strongest predictors to RBR with accuracy, sensitivity, specificity, area under the curve of 0.93, 0.99, 0.80, and 0.88, respectively. Conclusion In this study, a random forest algorithm was capable of selecting the best echocardiographic predictors to RBR pattern in NCC patients, which was consistent with worse systolic, diastolic, and myocardium deformation indices. Prospective studies are warranted to evaluate the role of this tool for NCC risk stratification.