ANA SOLEDADE GRAEFF MARTINS
Índice h a partir de 2011
9
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- Dimensions of Oppositionalay in a Brazilian Communiiy Sample: Testing the DSM-5 Proposal and Etiological Links(2013) KRIEGER, Fernanda Valle; POLANCZYK, Guilherme Vanoni; GOODMAN, Robert; ROHDE, Luis Augusto; GRAEFF-MARTINS, Ana Soledade; SALUM, Giovanni; GADELHA, Ary; PAN, Pedro; STAHL, Daniel; STRINGARIS, ArgyrisObjective: Investigating dimensions of oppositional symptoms may help to explain heterogeneity of etiology and outcomes for mental disorders across development and provide further empirical justification for the DSM-5-proposed modifications of oppositional defiant disorder (ODD). However, dimensions of oppositionality have not previously been tested in samples outside Europe or the United States. In this study, we used a large Brazilian community sample to compare the fit of different models for dimensions of oppositional symptoms; to examine the association of psychiatric diagnoses and symptoms with dimensions of oppositionality; and to examine the associations between dimensions of oppositionality and parental history of mental disorders. Method: A Brazilian community sample of 2,512 children 6 through 12 years old were investigated in this study. Confirmatory factorial analyses were performed to compare the fit of alternative models, followed by linear and logistic regression analyses of associations with psychiatric diagnosis and parental history of psychopathology. Results: A three-factor model with irritable, headstrong, and hurtful dimensions fitted best. The irritable dimension showed a strong association with emotional disorders in the child (p < .001) and history of depression (p < .01) and suicidality (p < .05) in the mother. The headstrong dimension was uniquely associated with attention-deficit/hyperactivity disorder (ADHD) in the child (p < .001) and with maternal history of ADHD symptoms (p < .05). The hurtful dimension was specifically associated with conduct disorder (p < .05). Conclusions: Our findings from a large community sample of Brazilian children support a distinction between dimensions of oppositionality consistent with current DSM-5 recommendations and provide further evidence for etiological distinctions between these dimensions. J. Am. Acad. Child Adolesc. Psychiatry; 201352(4):389-400.
- Manic Symptoms in Youth: Dimensions, Latent Classes, and Associations With Parental Psychopathology(2014) PAN, Pedro Mario; SALUM, Giovanni Abrahao; GADELHA, Ary; MORIYAMA, Tais; COGO-MOREIRA, Hugo; GRAEFF-MARTINS, Ana Soledade; ROSARIO, Maria Conceicao; POLANCZYK, Guilherme Vanoni; BRIETZKE, Elisa; ROHDE, Luis Augusto; STRINGARIS, Argyris; GOODMAN, Robert; LEIBENLUFT, Ellen; BRESSAN, Rodrigo AffonsecaObjective: The purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children. Method: We screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with ""episodes of going abnormally high"" completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with ""Under-Control (UC)"" and ""Exuberant (EX)"" dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested. Results: The 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with ""episodes of going abnormally high,"" but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment (""high-symptom group""). Conclusion: In a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.