LETICIA LESSA MANSUR
Projetos de Pesquisa
Unidades Organizacionais
LIM/34 - Laboratório de Ciências da Reabilitação, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
- Inference comprehension from reading in individuals with mild cognitive impairment(2021) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; OLIVEIRA, Maira Okada de; TRES, Eduardo Sturzeneker; BRUCKI, Sonia Maria Dozzi; RADANOVIC, Marcia; MANSUR, Leticia LessaInference comprehension is a complex ability that recruits distinct cognitive domains, such as language, memory, attention, and executive functions. Therefore, it might be sensitive to identify early deficits in subjects with MCI. To compare the performance of subjects with mild cognitive impairment (MCI) in an inference reading comprehension task, and to analyze the correlations between inferential comprehension and other cognitive functions. We studied 100 individuals aged 60 and over, divided into MCI (50) [aMCI (35), naMCI (15)], and cognitively healthy individuals [controls (50)]. The Implicit Management Test (IMT) was used to assess inference in reading comprehension in five categories: explicit, logical, distractor, pragmatic, and ""others"". MCI group performed worse than controls in logical, pragmatic, distractor, and ""others"" questions (p < 0.01). The aMCI and naMCI subgroups presented a similar performance in all types of questions (p > 0.05). We observed significant correlations between the total IMT score and the TMT-A in the naMCI group (r = - 0.562, p = 0.036), and the Rey-Osterrieth Complex Figure and RAVLT tasks in the aMCI group (r = 0.474, p = 0.010 and r = 0.593, p = 0.0001, respectively). The MCI group as a whole performed worse than controls on the logical, pragmatic, other and distractor questions, and consequently on the total score. There were no differences in explicit questions, which impose lower inferential demands. The aMCI group suffered a significant impact from memory on inference comprehension, and difficulties in executive functions impacted naMCI performance. The IMT was useful to differentiate MCI patients from cognitively healthy individuals, but not MCI subgroups among themselves.
- Language impairment in Huntington's disease(2012) AZAMBUJA, Mariana Jardim; RADANOVIC, Marcia; HADDAD, Monica Santoro; ADDA, Carla Cristina; BARBOSA, Egberto Reis; MANSUR, Leticia LessaLanguage alterations in Huntington's disease (HD) are reported, but their nature and correlation with other cognitive impairments are still under investigation. This study aimed to characterize the language disturbances in HD and to correlate them to motor and cognitive aspects of the disease. We studied 23 HD patients and 23 controls, matched for age and schooling, using the Boston Diagnostic Aphasia Examination, Boston Naming Test, the Token Test, Animal fluency, Action fluency, FAS-COWA, the Symbol Digit Modalities Test, the Stroop Test and the Hooper Visual Organization Test (HVOT). HD patients performed poorer in verbal fluency (p<0.0001), oral comprehension (p<0.0001), repetition (p<0.0001), oral agility (p<0.0001), reading comprehension (p=0.034) and narrative writing (p<0.0001). There was a moderate correlation between the Expressive Component and Language Competency Indexes and the HVOT (r=0.519, p=0.011 and r=0.450, p=0.031, respectively). Language alterations in HD seem to reflect a derangement in both frontostriatal and frontotemporal regions.
- Aphasia in vascular lesions of the basal ganglia: A comprehensive review(2017) RADANOVIC, Marcia; MANSUR, Leticia LessaBetween 1970 and 1990, the study of aphasia secondary to subcortical lesions (including the basal ganglia - BG) was largely driven by the advent of modern neuroimaging techniques such as MRI and PET. However, attempts to characterize a pattern of language abnormalities in patients with basal ganglia lesions proved unfruitful. We conducted a comprehensive review of language disturbances after vascular lesions in the BC. Literature search in Medline and LILACS (1966-2016) and PsychINFO (last 25 years) was conducted, and returned 145 articles, with 57 eligible for the review yielding data on 303 patients. We report the clinical and neuroimaging features of these cases. Results showed that aphasias caused by BG lesions are heterogeneous with weak clinicoanatomical correlations. Data derived from follow-up and flow/metabolism studies suggest that subcortical aphasia caused by BG lesions involves hypoperfusion in the cortical territories of the middle cerebral/internal carotid arteries (MCA/ICA) and their branches.
- Comparison of language impairment in late-onset depression and Alzheimer's disease(2011) NOVARETTI, Tania M. da Silva; FREITAS, Maria I. D'Avila; MANSUR, Leticia L.; NITRINI, Ricardo; RADANOVIC, MarciaObjectives: Depression and dementia are highly prevalent in the elderly. Language impairment is an inherent component of Alzheimer's disease (AD), which can also be encountered in depressed patients. The aim of this study wasto compare the profiles of language abilities in late-onset depression and mild AD groups. Methods: We studied 25 patients with late-onset depression (mean age 73.6 +/- 6.6 years; schooling 9.1 +/- 5.7 years) and 30 patients with mild AD (77.6 +/- 5.4 years; 7.5 +/- 7.1 years) using the Arizona Battery for Communication Disorders of Dementia (ABCD), compared to a group of 30 controls (73.8 +/- 5.8 years; 9.1 +/- 5.4 years). Cut-off scores to discriminate between Controls x Depression and Depression x AD were determined. Results: Depressed patients' scores were similar to AD in confrontation naming, concept definition, following commands, repetition and reading comprehension (sentence). Episodic memory and mental status subtests were useful in differentiating depressed patients from AD, a result that was reproduced when using analysis of covariance to control for the effect of age in the same subtests (p = 0.01 and 0.04, respectively). Conclusion: Language impairment resembling AD was found in the aforementioned language subtests of the ABCD in elderly depressed patients; the mental status and episodic memory subtests were useful to discriminate between AD and depression. The ABCD has proven to be a suitable tool for language evaluation in this population and should aid in the differentiation of AD and pseudodementia (as that of depression).
- Inference comprehension during reading: influence of age and education in normal adults(2014) SILAGI, Marcela Lima; ROMERO, Vivian Urbanejo; MANSUR, Leticia Lessa; RADANOVIC, MarciaPurpose: To determine the effect of age and education on inferential comprehension from written texts in normal individuals. Methods: A total of 224 normal adults were stratified into nine groups according to age (young: 18–39 years, adults: 40–59 years, and elderly: 60–79 years) and educational level (low ≤4 years, medium: 5–8 years and high >8 years) and were evaluated through the battery La gestion de l'implicite (Implicit Information Management Test) to determine the ability to make inferences through different types of questions: explicit, logical, distractor, pragmatic and others. Results: The elderly showed worse performance for total score and distractor questions. Regarding educational level, all groups differed on explicit, logical, distractor questions, and on total test score. Subjects with high schooling performed better on pragmatic inferences and others. Conclusion: Age influence on the comprehension of inferences may be due to difficulties in attention and executive functions. The strong effect of education can be explained by the interaction of inferential abilities with other cognitive functions such as working memory, vocabulary span, as well as world knowledge.
- Linguistic abilities in major vascular cognitive impairment: a comparative study with Alzheimer's disease(2018) FREITAS, Maria Isabel D'Avila; PORTO, Claudia S.; OLIVEIRA, Maira O.; BRUCKI, Sonia M. D.; MANSUR, Leticia L.; NITRINI, Ricardo; RADANOVIC, MarciaWe assessed the linguistic abilities of multi-infarct (cortical) dementia and subcortical ischemic vascular dementia (VaD) patients and compared the linguistic performance of VaD and Alzheimer's Disease (AD) patients. A total of 23 VaD patients, 20 mild AD patients, and 31 controls participated in the study. All were evaluated using the Arizona Battery for Communication Disorders of Dementia (ABCD). Neuropsychological testing was performed to ascertain that VaD and AD patients had comparable cognitive performance. Both dementia groups performed more poorly than controls in the ABCD measures, except for the comparative question subtest. Comparison between VaD and AD patients showed statistically significant differences only in the confrontation naming subtest (p < 0.05), where paraphasias and visual errors were the most prevalent. AD patients showed a trend towards more circumlocution errors than VaD patients (p = 0.0483). When compared to controls, linguistic abilities of VaD patients were impaired in all measures of linguistic expression and linguistic comprehension, except for the comparative question subtest. Linguistic differences between VaD and AD patients were observed only in the confrontation naming subtest.
- Applicability of the ""An Object and Action Naming Battery"" in Brazilian Portuguese(2013) SPEZZANO, Luisa Carmen; MANSUR, Leticia Lessa; RADANOVIC, MarciaPURPOSE: To verify the performance of a sample of Brazilian subjects in the ""An Object and Action Naming Battery"" (OANB), according to schooling; and to describe the main error types in nouns and verbs naming. METHODS: The OANB was applied in 100 healthy subjects, divided in two groups (GI: four to eight years of schooling; and GII: above nine years). RESULTS: There were correct answers for 97.6% for nouns and 98.0% for verbs. There were statistically significant differences between the groups in the number of correct answers for nouns and verbs (p<0.0001) and in the proportion of semantic errors for verbs (p=0.0160), with less educated subjects performing poorer than higher educated ones. CONCLUSION: The OANB may be used in adult Brazilian Portuguese native speakers. The group with higher education had higher scores; both groups had a higher proportion of ""semantic errors"" for verbs and nouns.
- Inference comprehension in text reading: Performance of individuals with right- versus left-hemisphere lesions and the influence of cognitive functions(2018) SILAGI, Marcela Lima; RADANOVIC, Marcia; CONFORTO, Adriana Bastos; MENDONCA, Lucia Iracema Zanotto; MANSUR, Leticia LessaBackground Right-hemisphere lesions (RHL) may impair inference comprehension. However, comparative studies between left-hemisphere lesions (LHL) and RHL are rare, especially regarding reading comprehension. Moreover, further knowledge of the influence of cognition on inferential processing in this task is needed. Objectives To compare the performance of patients with RHL and LHL on an inference reading comprehension task. We also aimed to analyze the effects of lesion site and to verify correlations between cognitive functions and performance on the task. Methods Seventy-five subjects were equally divided into the groups RHL, LHL, and control group (CG). The Implicit Management Test was used to evaluate inference comprehension. In this test, subjects read short written passages and subsequently answer five types of questions (explicit, logical, distractor, pragmatic, and other), which require different types of inferential reasoning. The cognitive functional domains of attention, memory, executive functions, language, and visuospatial abilities were assessed using the Cognitive Linguistic Quick Test (CLQT). Results The LHL and RHL groups presented difficulties in inferential comprehension in comparison with the CG. However, the RHL group presented lower scores than the LHL group on logical, pragmatic and otherquestions. A covariance analysis did not show any effect of lesion site within the hemispheres. Overall, all cognitive domains were correlated with all the types of questions from the inference test (especially logical, pragmatic, and other). Attention and visuospatial abilities affected the scores of both the RHL and LHL groups, and only memory influenced the performance of the RHL group. Conclusions Lesions in either hemisphere may cause difficulties in making inferences during reading. However, processing more complex inferences was more difficult for patients with RHL than for those with LHL, which suggests that the right hemisphere plays an important role in tasks with higher comprehension demands. Cognition influences inferential processing during reading in brain-injured subjects.
- Impairment of Inferential Abilities Based on Pictorial Stimuli in Patients With Right-Hemisphere Damage(2015) RIBEIRO, Ariella Fornachari; MANSUR, Leticia Lessa; RADANOVIC, MarciaInferences are mental representations derived from the interaction between explicit linguistic information and an individual's world knowledge. The right hemisphere (RH) is the main region responsible for this ability, particularly with regard to pictorial stimuli. The aims of this study were to evaluate the performance of RH-damaged patients on an inference comprehension task based on pictorial stimuli and to compare the effect of different lesion sites on this performance. We compared the inferential abilities of 75 healthy controls and 50 patients with RH damage of vascular origin using 13 pictorial stimuli from the instrument ""300 Exercises of Comprehension of Logical and Pragmatic Inferences and Causal Chains."" RH-damaged patients performed worse than controls in comprehending logical and pragmatic visual inferences independent of lesion site (p<.0001). The subgroup with posterior lesions performed worse than the other subgroups.