FABIANA GOULART MARCONDES BRAGA

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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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  • article 0 Citação(ões) na Scopus
    Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
    (2024) DELAFIORI, Jeany; SICILIANO, Rinaldo Focaccia; OLIVEIRA, Arthur Noin de; NICOLAU, Jose Carlos; SALES, Geovana Manzan; DALCOQUIO, Talia Falcao; BUSANELLO, Estela Natacha Brandt; EGUTI, Adriana; OLIVEIRA, Diogo Noin de; BERTOLIN, Adriadne Justi; SANTOS, Luiz Augusto dos; SALSOSO, Rocio; MARCONDES-BRAGA, Fabiana G.; DURAN, Nelson; JR, Mauricio Wesley Perroud; SABINO, Ester Cerdeira; REIS, Leonardo Oliveira; FAVARO, Wagner Jose; CATHARINO, Rodrigo Ramos
    As SARS-CoV-2 continues to produce new variants, the demand for diagnostics and a better understanding of COVID-19 remain key topics in healthcare. Skin manifestations have been widely reported in cases of COVID-19, but the mechanisms and markers of these symptoms are poorly described. In this cross-sectional study, 101 patients (64 COVID-19 positive patients and 37 controls) were enrolled between April and June 2020, during the first wave of COVID-19, in Sao Paulo, Brazil. Enrolled patients had skin imprints sampled non-invasively using silica plates; plasma samples were also collected. Samples were used for untargeted lipidomics/metabolomics through high-resolution mass spectrometry. We identified 558 molecular ions, with lipids comprising most of them. We found 245 plasma ions that were significant for COVID-19 diagnosis, compared to 61 from the skin imprints. Plasma samples outperformed skin imprints in distinguishing patients with COVID-19 from controls, with F1-scores of 91.9% and 84.3%, respectively. Skin imprints were excellent for assessing disease severity, exhibiting an F1-score of 93.5% when discriminating between patient hospitalization and home care statuses. Specifically, oleamide and linoleamide were the most discriminative biomarkers for identifying hospitalized patients through skin imprinting, and palmitic amides and N-acylethanolamine 18:0 were also identified as significant biomarkers. These observations underscore the importance of primary fatty acid amides and N-acylethanolamines in immunomodulatory processes and metabolic disorders. These findings confirm the potential utility of skin imprinting as a valuable non-invasive sampling method for COVID-19 screening; a method that may also be applied in the evaluation of other medical conditions.Key messagesSkin imprints complement plasma in disease metabolomics.The annotated markers have a role in immunomodulation and metabolic diseases.Skin imprints outperformed plasma samples at assessing disease severity.Skin imprints have potential as non-invasive sampling strategy for COVID-19.