WALCY PAGANELLI ROSOLIA TEODORO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina
17 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 17
conferenceObject Collagen V activation and matrix extracellular remodeling mediated pulmonary fibrosis in experimental models of bleomycin and 3-5-di-tert-4-hidroxitoluene(2013) LOPES, Deborah; MARTINS, Vanessa; TEODORO, Walcy; ROGER, Edwin; CAPELOZZI, Vera LuizaconferenceObject Type V collagen induced pulmonary fibrosis in C57B1/6mice(2014) TEODORO, Walcy Rosolia; VELOSA, Ana Paula Pereira; SANTOS FILHO, Antonio dos; ANDRADE, Priscila Cristina; MARTINS, Vanessa; FERNEZLIAN, Sandra Morais; CATANOZI, Sergio; CAPELOZZI, Vera LuisaconferenceObject Collagen V Maintains Experimental Pulmonary Fibrosis In Il17-dependent And -Independent Pathways(2013) FABRO, A. T.; SILVA, P. Q.; ZOCOLARO, W. S.; ALMEIDA, M. S.; MINATEL, I. O.; PRANDO, E. C.; RAINHO, C. A.; VELOSA, A. P.; TEODORO, W. R.; PARRA-CUENTAS, E. R.; POPPER, H. H.; CAPELOZZI, V. L.conferenceObject Metalloproteases gene expression and remodeling of lung parenchyma fibers during the progression of elastase induced emphysema(2014) ROBERTONI, Fabiola Santos Zambon; OLIVO, Clarice Rosa; LOURENCO, Juliana Dias; GONCALVES, Natalia Comes; VELOSA, Ana Paula Pereira; TEODORO, Walcy Rosolia; LIN, Chin Jia; MARTINS, Milton De Arruda; LOPES, Fernanda D. T. Q. dos Santos- Pulmonary fibrosis modulation by mesenchymal stem cells and conditioned medium(2019) FELIX, Renato Goncalves; BOVOLATO, Ana Livia Carvalho Bovolato Carvalho; LEAO, Patricia Dos Santos Leao Dos Santos; GOLIM, Marjorie De Assis Golim De Assis; TEODORO, Walcy Rosolia Teodoro Rosolia; FABRO, Alexandre Todorovic; DEFFUNE, Elenice; CAPELOZZI, Vera Luiza
conferenceObject Temporal profile of metaloproteases gene expression in elastase-induced emphysema(2013) ROBERTONI, Fabiola Santos Zambon; OLIVO, Clarice Rosa; LOURENCO, Juliana Dias; GANCALVES, Natalia Gomes; VELOSA, Ana Paula Pereira; TEODORO, Walcy Rosolia; LIN, Chin Jia; MARTINS, Milton de Arruda; LOPES, Fernanda Degobbi Tenorio Q. S.- Combining Immunoprofile, Immunogenic Collagen and Mismatch Repair Proteins Predicts Risk of Death and Target Therapy in Malignant Mesothelioma(2019) MACHADO-RUGOLO, J.; BALANCIN, M.; MARTINS, V.; MIRANDA, J.; ASSATO, A.; SOUZA, N.; VELOSA, A. P.; FALZONI, R.; AB'SABER, A.; TEODORO, W.; CAPELOZZI, V.
- Effects of acute hypercapnia with and without acidosis on lung inflammation and apoptosis in experimental acute lung injury(2015) NARDELLI, L. M.; RZEZINSKI, A.; SILVA, J. D.; MARON-GUTIERREZ, T.; ORNELLAS, D. S.; HENRIQUES, I.; CAPELOZZI, V. L.; TEODORO, W.; MORALES, M. M.; SILVA, P. L.; PELOSI, P.; GARCIA, C. S. N. B.; ROCCO, P. R. M.We investigated the effects of acute hypercapnic acidosis and buffered hypercapnia on lung inflammation and apoptosis in experimental acute lung injury (ALI). Twenty-four hours after paraquat injection, 28 Wistar rats were randomized into four groups (n = 7/group): (1) normocapnia (NC, PaCO2 = 35-45 mmHg), ventilated with 0.03%CO2 + 21%O-2 + balanced N-2; (2) hypercapnic acidosis (HC, PaCO2 = 60-70 mmHg), ventilated with 5%CO2 + 21%O-2 + balanced N-2; and (3) buffered hypercapnic acidosis (BHC), ventilated with 5%CO2 + 21%O-2 + balanced N-2 and treated with sodium bicarbonate (8.4%). The remaining seven animals were not mechanically ventilated (NV). The mRNA expression of interleukin (IL)-6 (p = 0.003), IL-1 beta (p<0.001), and type III procollagen (PCIII) (p = 0.001) in lung tissue was more reduced in the HC group in comparison with NC, with no significant differences between HC and BHC. Lung and kidney cell apoptosis was reduced in HC and BHC in comparison with NC and NV. In conclusion, in this experimental ALI model, hypercapnia, regardless of acidosis, reduced lung inflammation and lung and kidney cell apoptosis.
conferenceObject Immune, Matrix And Etiologic Profile Of Necrotizig And Non-Necrotizing Granulomatous Lung Diseases(2015) MARTINS, V.; SOUZA, P.; LOPES, D.; MOSCARDI, M.; CRUZ, I. B. Da; KAWASAKI, A.; TEODORO, W. R.; RODRIGUES, S. C. S.; LIMA, M. S.; CASTELLANO, M.; FABRO, A. T.; COLETTA, E.; CAPELOZZI, V. L.- Early and late effects of bone marrow-derived mononuclear cell therapy on lung and distal organs in experimental sepsis(2011) ORNELLAS, Debora S.; MARON-GUTIERREZ, Tatiana; ORNELLAS, Felipe M.; CRUZ, Fernanda F.; OLIVEIRA, Gisele P.; LUCAS, Isabela H.; FUJISAKI, Livia; OLIVEIRA, Mariana G.; TEODORO, Walcy R.; CAPELOZZI, Vera L.; PELOSI, Paolo; MORALES, Marcelo M.; ROCCO, Patricia R. M.We tested the hypothesis that bone marrow-derived mononuclear cells (BMDMCs) at an early phase of cecal ligation and puncture (CLP)-induced sepsis may have lasting effects on: (1) lung mechanics and histology, (2) the structural remodelling of lung parenchyma, (3) lung, kidney, and liver cell apoptosis, and (4) pro- and anti-inflammatory cytokines and growth factors. At day 1, BMDMC significantly reduced mortality, as well as caspase-3, interleukin (IL)-6 and IL-1 beta vascular endothelial growth factor, platelet-derived growth factor, hepatocyte growth factor, and transforming growth factor-beta, but increased IL-10 mRNA expression in lung tissue in septic mice contributing to endothelium and epithelium alveolar repair and improvement of lung mechanics. BMDMC also prevented the increase of apoptotic cells in lung, liver, and kidney. At day 7, these early functional and morphological effects were preserved or further improved. In conclusion, in the present model of sepsis, the beneficial effects of early administration of BMDMCs on lung and distal organs were preserved, possibly by paracrine mechanisms.