MARIA CRISTINA DONADIO ABDUCH

(Fonte: Lattes)
Índice h a partir de 2011
10
Lattes
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

search.filters.applied.f.dateIssued: 2021 ×

Resultados de Busca

Agora exibindo 1 - 3 de 3
  • article 6 Citação(ões) na Scopus
    Effects of inspiratory muscle training combined with aerobic exercise training on neurovascular control in chronic heart failure patients
    (2021) TREVIZAN, Patricia F.; ANTUNES-CORREA, Ligia M.; LOBO, Denise M. L.; OLIVEIRA, Patricia A.; ALMEIDA, Dirceu R. de; ABDUCH, Maria Cristina D.; MATHIAS JUNIOR, Wilson; HAJJAR, Ludhmila Abrahao; KALIL FILHO, Roberto; NEGRAO, Carlos Eduardo
    Aims We tested the hypothesis that the effects of combined inspiratory muscle training and aerobic exercise training (IMT + AET) on muscle sympathetic nerve activity (MSNA) and forearm blood flow in patients with heart failure with reduced ejection fraction are more pronounced than the effects of AET alone. Methods and results Patients aged 30-70 years, New York Heart Association Functional Class II-III, and left ventricular ejection fraction <= 40% were randomly assigned to four groups: IMT (n = 11), AET (n = 12), IMT + AET (n = 9), and non-training (NT; n = 10). MSNA was recorded using microneurography. Forearm blood flow was measured by venous occlusion plethysmography and inspiratory muscle strength by maximal inspiratory pressure. IMT consisted of 30 min sessions, five times a week, for 4 months. Moderate AET consisted of 60 min sessions, three times a week for 4 months. AET (-10 +/- 2 bursts/min, P = 0.03) and IMT + AET (-13 +/- 4 bursts/min, P = 0.007) reduced MSNA. These responses in MSNA were not different between AET and IMT + AET groups. IMT (0.22 +/- 0.08 mL/min/100 mL, P = 0.03), AET (0.27 +/- 0.09 mL/min/100 mL, P = 0.01), and IMT + AET (0.35 +/- 0.12 mL/min/100 mL, P = 0.008) increased forearm blood flow. No differences were found between groups. AET (3 +/- 1 mL/kg/min, P = 0.006) and IMT + AET (4 +/- 1 mL/kg/min, P = 0.001) increased peak oxygen consumption. These responses were similar between these groups. IMT (20 +/- 3 cmH(2)O, P = 0.005) and IMT + AET (18 +/- 3 cmH(2)O, P = 0.01) increased maximal inspiratory pressure. No significant changes were observed in the NT group. Conclusions IMT + AET causes no additive effects on neurovascular control in patients with heart failure with reduced ejection fraction compared with AET alone. These findings may be, in part, because few patients had inspiratory muscle weakness.
  • article 0 Citação(ões) na Scopus
    Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation (vol 19, 6, 2021)
    (2021) CRUZ, Cecilia Beatriz Bittencourt Viana; HAJJAR, Ludhmila A.; BACAL, Fernando; LOFRANO-ALVES, Marco S.; LIMA, Marcio S. M.; ABDUCH, Maria C.; VIEIRA, Marcelo Luiz Campos; CHIANG, Hsu P.; SALVIANO, Juliana B. C.; COSTA, Isabela Bispo Santos da Silva; FUKUSHIMA, Julia Tizue; SBANO, Joao C. N.; MATHIAS JR., Wilson; TSUTSUI, Jeane M.
    An amendment to this paper has been published and can be accessed via the original article.
  • article 9 Citação(ões) na Scopus
    Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation
    (2021) CRUZ, Cecilia Beatriz Bittencourt Viana; HAJJAR, Ludhmila A.; BACAL, Fernando; LOFRANO-ALVES, Marco S.; LIMA, Marcio S. M.; ABDUCH, Maria C.; VIERA, Marcelo L. C.; CHIANG, Hsu P.; SALVIANO, Juliana B. C.; COSTA, Isabela Bispo Santos da Silva; FUKUSHIMA, Julia Tizue; SBANO, Joao C. N.; JR, Wilson Mathias; TSUTSUI, Jeane M.
    Background: Acute cellular rejection (ACR) is a major complication after heart transplantation. Endomyocardial biopsy (EMB) remains the gold standard for its diagnosis, but it has concerning complications. We evaluated the usefulness of speckle tracking echocardiography (STE) and biomarkers for detecting ACR after heart transplantation. Methods: We prospectively studied 60 transplant patients with normal left and right ventricular systolic function who underwent EMB for surveillance 6 months after transplantation. Sixty age- and sex-matched healthy individuals constituted the control group. Conventional echocardiographic parameters, left ventricular global longitudinal, radial and circumferential strain (LV-GLS, LV-GRS and LV-GCS, respectively), left ventricular systolic twist (LV-twist) and right ventricular free wall longitudinal strain (RV-FWLS) were analyzed just before the procedure. We also measured biomarkers at the same moment. Results: Among the 60 studied patients, 17 (28%) had severe ACR (grade >= 2R), and 43 (72%) had no significant ACR (grade 0 - 1R). The absolute values of LV-GLS, LV-twist and RV-FWLS were lower in transplant patients with ACR degree >= 2 R than in those without ACR (12.5% +/- 2.9% vs 14.8% +/- 2.3%, p=0.002; 13.9 degrees +/- 4.8 degrees vs 17.1 degrees +/- 3.2 degrees, p=0.048; 16.6% +/- 2.9% vs 21.4%+/- 3.2%, p < 0.001; respectively), while no differences were observed between the LV-GRS or LV-GCS. All of these parameters were lower in the transplant group without ACR than in the nontransplant control group, except for the LV-twist. Cardiac troponin I levels were significantly higher in patients with significant ACR than in patients without significant ACR [0.19 ng/mL (0.09-1.31) vs 0.05 ng/mL (0.01-0.18), p=0.007]. The combination of troponin with LV-GLS, RV-FWLS and LV-Twist had an area under curve for the detection of ACR of 0.80 (0.68-0.92), 0.89 (0.81-0.93) and 0.79 (0.66-0.92), respectively. Conclusion: Heart transplant patients have altered left ventricular dynamics compared with control individuals. The combination of troponin with strain parameters had higher accuracy for the detection of ACR than the isolated variables and this association might select patients with a higher risk for ACR who will benefit from an EMB procedure in the first year after heart transplantation.