MAURICIO SIMOES ABRAO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Preoperative Ultrasound Scoring of Endometriosis by AAGL 2021 Endometriosis Classification Is Concordant with Laparoscopic Surgical Findings and Distinguishes Early from Advanced Stages(2023) ABRAO, Mauricio S.; ANDRES, Marina Paula; GINGOLD, Julian A.; RIUS, Mariona; NETO, Joao Siufi; GONCALVES, Manoel Orlando; GIOVANNI, Alessandra Di; MALZONI, Mario; CARMONA, FranciscoStudy Objective: To compare the accuracy of preoperative ultrasound (US) in predicting the laparoscopically defined 2021 American Association of Gynecologic Laparoscopists (AAGL) Endometriosis Staging. Design: Retrospective multicenter study of patients treated at 3 specialized endometriosis centers. Setting: Three specialized endometriosis surgical centers in Sao Paulo (Brazil), Barcelona (Spain), and Avellino (Italy) participated. Patients: A total of 878 patients aged 15 to 45 years with no history of pelvic malignancy underwent laparoscopic (LPS) treatment for suspected endometriosis. Interventions: Retrospective review of preoperative transvaginal and transabdominal US (index test) assessed for endometriosis at all sites used in the 2021 AAGL Endometriosis Classification and classified patients into AAGL-US stages 1 to 4. Results were compared with reference-standard LPS (AAGL-LPS) staging. Measurements and Main Results: The AAGL-US and AAGL-LPS stage were concordant in 586 cases (66.7%) (weighted kappa [WK] 0.759; intraclass correlation = 0.906), with the highest agreement observed in patients with no endometriosis (n = 70, 75.3% concordance), AAGL-LPS stage 1 (104, 50.7%) and stage 4 disease (358, 88.2%). Endometriosis was most accurately diagnosed in the rectum/sigmoid colon (WK 0.862), bladder (WK 0.911), and ovaries (WK 0.835/0.795 for right/left, respectively) and least accurately diagnosed at superficial peritoneal (WK 0.442), tubal (WK 0.391/0.363 for right/left, respectively), and retrocervical/uterosacral ligament (WK 0.656) sites. Conclusion: Sonographic estimation of the 2021 AAGL Endometriosis Staging is greatest in AAGL-LPS stages 1 and 4 and among patients with no endometriosis. US best identifies endometriosis of the ovaries, bladder, and bowel but is more limited for the tubes and superficial peritoneum. Journal of Minimally Invasive Gynecology (2023) 30, 363- 373.
- Endometriosis and recurrent pregnancy loss: two manifestations of the same underlying dysfunction?(2023) VIDALI, Andrea; RICCIO, Luiza Gama Coelho; ABRAO, Mauricio Simoes
- Opportunistic Salpingectomy for Ovarian Cancer Prevention: A Call for Action(2023) RIUS, Mariona; CARUGNO, Jose; ABRAO, Maurico S.; CARMONA, Francisco
conferenceObject IDENTIFICATION OF IMMUNOLOGIC PREDICTIVE BIOMARKERS OF ENDOMETRIOSIS USING A NON-INVASIVE IMMUNE SCREENING TEST IN ASSOCIATION WITH MACHINE LEARNING MODELING(2023) ATTIA, Nadera Mansouri; FRANZOI, Marco; MCHALE, Melissa P.; GARGIULO, Antonio R.; ABRAO, Mauricio S.; VIDALI, Andrea- Deep Endometriosis: the Involvement of Multiple Pelvic Compartments Is Associated with More Severe Pain Symptoms and Infertility(2023) ROCHA, Taina Pezzin; ANDRES, Marina Paula; CARMONA, Francisco; BARACAT, Edmund Chada; ABRAO, Mauricio SimoesEndometriosis can be classified into three phenotypes: superficial, ovarian, and deep. Deep endometriosis (DE) has been associated with more severe pain symptoms, although no large-scale studies have evaluated the association between pain intensity and infertility and the different compartments of the pelvis affected by superficial and DE. This retrospective study included 1116 women who underwent laparoscopy for endometriosis treatment at two referral centers between 2009 and 2019. For the evaluation of each symptom, patients were divided according to their visual analog scale score (< 7 and >= 7) and fertility status. On multiple logistic regression, severe dysmenorrhea and dyschezia were correlated with DE of the posterior compartment alone (odds ratio (OR) = 1.6, confidence interval (CI) 1.09-2.34, and p = 0.02 and OR = 2.09, CI 1.36-3.23, and p < 0.01, respectively) and in combination with other compartments. DE of the posterior and lateral compartments had the most consistent statistical power (OR = 3.55 for dysmenorrhea and OR = 4.4 for dyschezia). Infertility was associated with DE of the posterior compartment alone (OR = 1.6, CI 1.06-2.54, p = 0.04) and in combination with the anterior compartment (OR = 2.62, CI 1.29-5.29, p < 0.01), with the combination of posterior and anterior compartment having the highest OR value. Severe dyschezia and infertility were also correlated with the presence of multiple localizations of DE (p = 0.04 and p < 0.01). This study confirms the association between DE and severe pain symptoms as well as the influence of the number of DE compartments on the severity of symptoms and the chance of infertility.
- The modern woman disease: endometriosis and its different faces(2023) ABRAO, Mauricio S.; SIUFI NETO, Joao