MARIANA MATERA VERAS
Projetos de Pesquisa
Unidades Organizacionais
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
conferenceObject Prenatal exposure to marijuana causes morphological retinal changes in mice(2020) ZANTUT, Paulo; VERAS, Mariana; TAKAHASHI, Walter; BENEVENUTO, Sarah; SAFATLE, Angelica; PECORA, Ricardo; SALDIVA, Paulo; DAMICO, Francisco Max- A Short Period of Exposure to Air Pollution (PM2.5) Is Sufficient to Induce Dysbiosis, Hyperphagia, and Fat Mass Gain(2019) ZORDAO, Olivia P.; SANTOS, Andrey; CAMPOLIM, Clara Machado; SR., Raquel Ataide Lima; FERREIRA, Clilton Krauss; SAAD, Mario; SALDIVA, Paulo; VERAS, Mariana; PRADA, Patricia O.
conferenceObject Influence of exposure to concentrated urban air particles on the respiratory system of (LDLr-/-) mice(2014) MAUAD, Thais; ALEMANY, Adair; VERAS, Mariana; JUNIOR, Gabriel Ribeiro; COSTA, Natalia; CATANOZI, Sergio; ABDALLA, Dulcineia; SALDIVA, PauloconferenceObject Particulate air pollution affects alveolization in a juvenile mice model of asthma(2014) VERAS, Mariana; TELES, Aila; COSTA, Natalia; RIBEIRO-JUNIOR, Gabriel; SALDIVA, Paulo; MAUAD, Thais- Stereological approach to the pathology of lung aging in humans(2020) SANTOS, Fabricio; FROIO, Francisca Lucas; RIBEIRO JUNIOR, Gabriel; VERAS, Mariana Matera; JUSTO, Lisie; SALDIVA, Paulo; COSTA, Natalia De Souza Xavier; MAUAD, Thais
conferenceObject Air monitoring coverage in low-income countries: an observational study(2014) FAJERSZTAJN, Lais; VERAS, Mariana; BARROZO, Ligia V.; SALDIVA, PauloconferenceObject SIRT1, SIRT2, SIRT6 and P21 gene expression in the lungs of mice chronically exposed to ambient particulate matter(2014) MAUAD, Thais; RIBEIRO, Gabriel; VERAS, Mariana; COSTA, Natalia; SHIMADA, Ana; ALEMANY, Adair; MENDES, Thais; SALDIVA, Paulo; FARSKY, SandraconferenceObject Differentially expressed genes in the lungs of fetuses mice exposed to ambient air pollution(2014) MENDES-LOPES, Thais; VERAS, Mariana; COSTA, Natalia; MAZZOTTI, Tatiane; BRITO, Glauber; CHAMMAS, Roger; SALDIVA, Paulo; MAUAD, Thais- Air pollution: a potentially modifiable risk factor for lung cancer(2013) FAJERSZTAJN, Lais; VERAS, Mariana; BARROZO, Ligia Vizeu; SALDIVA, PauloEconomic growth and increased urbanization pose a new risk for cancer development: the exposure of high numbers of people to ambient air pollution. Epidemiological evidence that links air pollution to mortality from lung cancer is robust. An ability to produce high-quality scientific research that addresses these risks and the ability of local health authorities to understand and respond to these risks are basic requirements to solve the conflict between economic development and the preservation of human health. However, this is currently far from being achieved. Thus, this Science and Society article addresses the possibilities of expanding scientific networking to increase awareness of the risk of lung cancer that is promoted by air pollution.
- Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein(2020) ALVES, Nilmara de Oliveira; PEREIRA, Guilherme Martins; DOMENICO, Marlise Di; COSTANZO, Giovanna; BENEVENUTO, Sarah; FONOFF, Adriana M. de Oliveira; COSTA, Natalia de Souza Xavier; RIBEIRO JR., Gabriel; KAJITANI, Gustavo Satoru; MORENO, Natalia Cestari; FOTORAN, Wesley; TORRES, Janaina Iannicelli; ANDRADE, Jailson Bittencourt de; VERAS, Mariana Matera; ARTAXO, Paulo; MENCK, Carlos Frederico Martins; VASCONCELLOS, Perola de Castro; SALDIVA, PauloAir pollution represents a considerable threat to health worldwide. The Sao Paulo Metropolitan area, in Brazil, has a unique composition of atmospheric pollutants with a population of nearly 20 million people and 9 million passenger cars. It is long known that exposure to particulate matter less than 2.5 mu m (PM2.5) can cause various health effects such as DNA damage. One of the most versatile defense mechanisms against the accumulation of DNA damage is the nucleotide excision repair (NER), which includes XPC protein. However, the mechanisms by which NER protects against adverse health effects related to air pollution are largely unknown. We hypothesized that reduction of XPC activity may contribute to inflammation response, oxidative stress and DNA damage after PM2.5 exposure. To address these important questions, XPC knockout and wild type mice were exposed to PM2.5 using the Harvard Ambient Particle concentrator. Results from one-single exposure have shown a significant increase in the levels of anti-ICAM, IL-1 beta, and TNF-alpha in the polluted group when compared to the filtered air group. Continued chronic PM2.5 exposure increased levels of carbonylated proteins, especially in the lung of XPC mice, probably as a consequence of oxidative stress. As a response to DNA damage, XPC mice lungs exhibit increased gamma-H2AX, followed by severe atypical hyperplasia. Emissions from vehicles are composed of hazardous substances, with polycyclic aromatic hydrocarbons (PAHs) and metals being most frequently cited as the major contributors to negative health impacts. This analysis showed that benzo[b]fluoranthene, 2-nitrofluorene and 9,10-anthraquinone were the most abundant PAHs and derivatives. Taken together, these findings demonstrate the participation of XPC protein, and NER pathway, in the protection of mice against the carcinogenic potential of air pollution. This implicates that DNA is damaged directly (forming adducts) or indirectly (Reactive Oxygen Species) by the various compounds detected in urban PM2.5.