FRANCISCO AKIRA MALTA CARDOZO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Psoas muscle area and one-year mortality in a cohort of patients undergoing vascular surgery(2022) TAVARES, Caio Assis Moura; GUALANDRO, Danielle Menosi; CARDOZO, Francisco Akira Malta; ORANGES FILHO, Marcelo; ANDO, Sabrina de Mello; CALDERARO, Daniela; CARAMELLI, Bruno
conferenceObject Dabigatran versus Warfarin on Cognitive Outcomes in Nonvalvular Atrial Fibrillation: Results of the GIRAF Trial(2021) CARAMELLI, Bruno; YU, Pai C.; CARDOZO, Francisco A.; MAGALHAES, Iuri R.; FEITOSA, Raul R.; SPERA, Raphael; AMADO, Daniel; ROJAS, Maria Carmen Escalante; GUALANDRO, Danielle M.; CALDERARO, Daniela; TAVARES, Caio de Assis Moura A.; BORG-ES-JUNIOR, Flavio A.; PASTANA, Adriana F.; MATHEUS, Mariana G. Gomes; BRUCKI, Sonia M.; RODRIGUES, Ana C.; NITRINI, Ricardo M.; CARAMELLI, Paulo- ACE2 Expression and Risk Factors for COVID-19 Severity in Patients with Advanced Age(2020) TAVARES, Caio de Assis Moura; AVELINO-SILVA, Thiago Junqueira; BENARD, Gil; CARDOZO, Francisco Akira Malta; FERNANDES, Juliana Ruiz; GIRARDI, Adriana Castello Costa; JACOB FILHO, Wilson
- Cardiology referral during the COVID-19 pandemic(2021) SANTORIO, Nathalia Conci; CARDOZO, Francisco Akira Malta; MIADA, Rodrigo Freddi; PITTA, Fabio Grunspun; TAVARES, Caio de Assis Moura; HABRUM, Fabio Cetinic; PINESI, Henrique Trombini; MAGALHAES, Iuri Reseda; MENEZES, Maria Clara Saad; CARAMELLI, Bruno; CALDERARO, DanielaOBJECTIVES: This study presents the cardiology referral model adopted at the University of Sao Paulo-Hospital das Cli acute accent nicas complex during the initial period of the coronavirus disease (COVID-19) pandemic, main reasons for requesting a cardiologic evaluation, and clinical profile of and prognostic predictors in patients with COVID-19. METHODS: In this observational study, data of all cardiology referral requests between March 30, 2020 and July 6, 2020 were collected prospectively. A descriptive analysis of the reasons for cardiologic evaluation requests and the most common cardiologic diagnoses was performed. A multivariable model was used to identify independent predictors of in-hospital mortality among patients with COVID-19. RESULTS: Cardiologic evaluation was requested for 206 patients admitted to the ICHC-COVID. A diagnosis of COVID-19 was confirmed for 180 patients. Cardiologic complications occurred in 77.7% of the patients. Among these, decompensated heart failure was the most common complication (38.8%), followed by myocardial injury (35%), and arrhythmias, especially high ventricular response atrial fibrillation (17.7%). Advanced age, greater need of ventilatory support on admission, and pre-existing heart failure were independently associated with in -hospital mortality. CONCLUSIONS: A hybrid model combining in-person referral with remote discussion and teaching is a viable alternative to overcome COVID-19 limitations. Cardiologic evaluation remains important during the pan-demic, as patients with COVID-19 frequently develop cardiovascular complications or decompensation of the underlying heart disease.
- Effects of dabigatran versus warfarin on 2-year cognitive outcomes in old patients with atrial fibrillation: results from the GIRAF randomized clinical trial(2022) CARAMELLI, Bruno; YU, Pai Ching; CARDOZO, Francisco A. M.; MAGALHAES, Iuri R.; SPERA, Raphael R.; AMADO, Daniel K.; ESCALANTE-ROJAS, Maria C.; GUALANDRO, Danielle M.; CALDERARO, Daniela; TAVARES, Caio A. M.; BORGES-JUNIOR, Flavio A.; PASTANA, Adriana F.; MATHEUS, Mariana G.; BRUCKI, Sonia M. D.; RODRIGUES, Ana Carolina O.; NITRINI, Ricardo; CARAMELLI, PauloBackground: Observational studies support a role for oral anticoagulation to reduce the risk of dementia in atrial fibrillation patients, but conclusive data are lacking. Since dabigatran offers a more stable anticoagulation, we hypothesized it would reduce cognitive decline when compared to warfarin in old patients with atrial fibrillation. Methods: The GIRAF trial was a 24-month, randomized, parallel-group, controlled, open-label, hypothesis generating trial. The trial was done in six centers including a geriatric care unit, secondary and tertiary care cardiology hospitals in Sao Paulo, Brazil. We included patients aged >= 70 years and CHA2DS2-VASc score > 1. The primary endpoint was the absolute difference in cognitive performance at 2 years. Patients were assigned 1:1 to take dabigatran (110 or 150 mg twice daily) or warfarin, controlled by INR and followed for 24 months. Patients were evaluated at baseline and at 2 years with a comprehensive and thorough cognitive evaluation protocol of tests for different cognitive domains including the Montreal Cognitive Assessment (MoCA), Mini-Mental State Exam (MMSE), a composite neuropsychological test battery (NTB), and computer-generated tests (CGNT). Results: Between 2014 and 2019, 5523 participants were screened and 200 were assigned to dabigatran (N = 99) or warfarin (N = 101) treatment. After adjustment for age, log of years of education, and raw baseline score, the difference between the mean change from baseline in the dabigatran group minus warfarin group was - 0.12 for MMSE (95% confidence interval [CI] - 0.88 to 0.63; P = 0.75), 0.05 (95% CI - 0.07 to 0.18; P = 0.40) for NTB, - 0.15 (95% CI - 0.30 to 0.01; P = 0.06) for CGNT, and - 0.96 (95% CI - 1.80 to 0.13; P = 0.02) for MoCA, with higher values suggesting less cognitive decline in the warfarin group. Conclusions: For elderly patients with atrial fibrillation, and without cognitive compromise at baseline that did not have stroke and were adequately treated with warfarin (TTR of 70%) or dabigatran for 2 years, there was no statistical difference at 5% significance level in any of the cognitive outcomes after adjusting for multiple comparisons.
conferenceObject Dabigatran versus Warfarin on Cognitive Outcomes in Nonvalvular Atrial Fibrillation: Results of the GIRAF Trial(2021) CARAMELLI, Bruno; YU, Pai C.; CARDOZO, Francisco A.; MAGALHAES, Iuri R.; FEITOSA, Raul R.; SPERA, Raphael; AMADO, Daniel; ROJAS, Maria Carmen Escalante; GUALANDRO, Danielle M.; CALDERARO, Daniela; TAVARES, Caio de Assis Moura A.; BORGES-JUNIOR, Flavio A.; PASTANA, Adriana F.; MATHEUS, Mariana G. Gomes; BRUCKI, Sonia M.; RODRIGUES, Ana C.; NITRINI, Ricardo M.; CARAMELLI, Paulo- Statement on Antiplatelet Agents and Anticoagulants in Cardiology-2019(2019) V, Carlos Serrano Jr; SOEIRO, Alexandre de M.; LEAL, Tatiana C. A. Torres; GODOY, Lucas C.; BISELLI, Bruno; HATA, Luiz Akira; MARTINS, Eduardo B.; ABUD-MANTA, Isabela C. K.; TAVARES, Caio A. M.; CARDOZO, Francisco Akira Malta; JR, Mucio Tavares de Oliveira