DANIELI CASTRO OLIVEIRA DE ANDRADE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Antiphospholipid Antibody Profile Stability over Time: Prospective Results from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (""Registry"")(2019) GKROUZMAN, Elena; SEVIM, Ecem; FINIK, Jackie; ANDRADE, Danieli; PENGO, Vittorio; SCIASCIA, Savino; TEKTONIDOU, Maria; UGARTE, Amaia; CHIGHIZOLA, Cecilia; BELMONT, H. Michael; SANCHEZ, Laura Perez; JI, Lanlan; FORTIN, Paul; EFTHYMIOU, Maria; JESUS, Guilherme De; BRANCH, David; NALLI, Cecilia; PETRI, Michelle; CERVERA, Ricard; ROD, Esther; KNIGHT, Jason; ATSUMI, Tatsuya; WILLIS, Rohan; BERTOLACCINI, Maria Laura; COHEN, Hannah; RAND, Jacob; ERKAN, DorukconferenceObject Clinical and Laboratory Characteristics of Antiphospholipid Antibody Positive Patients Included in the APS ACTION Registry(2019) SEVIM, Ecem; ZISA, Diane; ANDRADE, Danieli; SCIASCIA, Savino; GEROSA, Maria; BELMONT, H. Michael; EFTHYMIOU, Maria; FORTIN, Paul R.; LOPEZ-PEDRERA, Rosario; RODRIGUEZ, Esther; WILLIS, Rohan; ERKAN, Doruk; BARBHAIYA, Medha- The Impact of Systemic Lupus Erythematosus on the Clinical Phenotype of Antiphospholipid Antibody-Positive Patients: Results From the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Clinical Database and Repository(2019) UNLU, Ozan; ERKAN, Doruk; BARBHAIYA, Medha; ANDRADE, Danieli; NASCIMENTO, Iana; ROSA, Renata; BANZATO, Alessandra; PENGO, Vittorio; UGARTE, Amaia; GEROSA, Maria; JI, Lanlan; EFTHYMIOU, Maria; BRANCH, D. Ware; JESUS, Guilherme Ramires de; TINCANI, Angela; BELMONT, H. Michael; FORTIN, Paul R.; PETRI, Michelle; RODRIGUEZ, Esther; PONS-ESTEL, Guillermo J.; KNIGHT, Jason S.; ATSUMI, Tatsuya; WILLIS, Rohan; ZUILY, Stephane; TEKTONIDOU, Maria G.Objective Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist regarding the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective of this study was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with SLE with those of aPL-positive patients without SLE. Methods A secure web-based data capture system was used to store patient demographic characteristics and aPL-related clinical and laboratory characteristics. Inclusion criteria included positive aPL according to the updated Sapporo classification criteria. Antiphospholipid antibody-positive patients fulfilling the American College of Rheumatology criteria for the classification of SLE (""aPL with SLE"") and those with no other autoimmune diseases (""aPL only"") were included in the analysis. Results Six hundred seventy-two aPL-positive patients were recruited from 24 international centers; 426 of these patients did not have other autoimmune disease, and 197 had SLE. The frequency of thrombocytopenia, hemolytic anemia, low complement levels, and IgA anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies was higher in the aPL-positive patients with SLE, whereas the frequency of cognitive dysfunction and IgG anti-beta(2)GPI antibodies was higher in the aPL-only group. The frequency of arterial and venous thromboses (including recurrent) as well as pregnancy morbidity was similar in the 2 groups. The prevalence of cardiovascular disease risk factors at the time of entry into the registry entry did not differ between the 2 groups, with the exception of current smoking, which was more frequent in aPL-positive patients with SLE. Conclusion Although the frequencies of thrombosis and pregnancy morbidity are similar in aPL-positive patients with and those without SLE, the diagnosis of SLE in patients with persistently positive aPL is associated with an increased frequency of thrombocytopenia, hemolytic anemia, low complement levels, and positive IgA anti-beta(2)GPI antibodies.
- Pregnancy outcomes in mixed connective tissue disease: a multicentre study(2019) RADIN, Massimo; SCHREIBER, Karen; CUADRADO, Maria Jose; CECCHI, Irene; ANDREOLI, Laura; FRANCESCHINI, Franco; CALEIRO, Teresa; ANDRADE, Danieli; GIBBONE, Elena; KHAMASHTA, Munther; BUYON, Jill; IZMIRLY, Peter; AGUIRRE, Maria Angeles; BENEDETTO, Chiara; ROCCATELLO, Dario; MAROZIO, Luca; SCIASCIA, SavinoObjectives. In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. Methods. This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive women ever pregnant who fulfilled the established criteria for MCTD with confirmed U1RNP positivity. Results. The foetal outcomes in 203 pregnancies were as follows: 146 (71.9%) live births, 38 (18.7%) miscarriages (first trimester pregnancy loss of <12 weeks gestation), 18 (8.9%) stillbirths (pregnancy loss after 20 weeks gestation) and 11 (5.4%) cases with intrauterine growth restriction. Maternal pregnancy outcomes were as follows: 8 (3.9%) developed pre-eclampsia, 2 (0.9%) developed eclampsia, 31 (15.3%) developed gestational hypertension and 3 (1.5%) developed gestational diabetes. Women with MCTD and aPL and pulmonary or muscular involvement had worse foetal outcomes compared with those without. Moreover, we report a case of complete congenital heart block (0.45%) and a case of cutaneous neonatal lupus, both born to a mother with positive isolated anti-U1RNP and negative anti-Ro/SSA antibodies. Conclusion. In our multicentre cohort, women with MCTD had a live birth rate of 72%. While the true frequency of heart block associated with anti-U1RNP remains to be determined, this study might raise the consideration of echocardiographic surveillance in this setting. Pregnancy counselling should be considered in women with MCTD.
- Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study(2019) JESUS, G. R. de; SCIASCIA, S.; ANDRADE, D.; BARBHAIYA, M.; TEKTONIDOU, M.; BANZATO, A.; PENGO, V.; JI, L.; MERONI, P. L.; UGARTE, A.; COHEN, H.; BRANCH, D. W.; ANDREOLI, L.; BELMONT, H. M.; FORTIN, P. R.; PETRI, M.; RODRIGUEZ, E.; CERVERA, R.; KNIGHT, J. S.; ATSUMI, T.; WILLIS, R.; NASCIMENTO, I. S.; ROSA, R.; ERKAN, D.; LEVY, R. A.Objective To evaluate the subsequent rate of thrombosis among women with obstetric antiphospholipid syndrome (Ob-APS) in a multicentre database of antiphospholipid antibody (aPL)-positive patients, and the clinical utility of the adjusted Global Antiphospholipid Syndrome Score (aGAPSS), a validated tool to assess the likelihood of developing new thrombosis, in this group of patients. Design Retrospective study. Setting The Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Clinical Database and Repository. Population Women with Ob-APS. Methods Comparison of clinical and laboratory characteristics and measurement of aGAPSS in women with Ob-APS, with or without thrombosis, after initial pregnancy morbidity (PM). Main outcome measures Risk factors for thrombosis and aGAPSS. Results Of 550 patients, 126 had Ob-APS; 74/126 (59%) presented with thrombosis, and 47 (63%) of these women developed thrombosis after initial PM, in a mean time of 7.6 +/- 8.2 years (4.9/100 patient years). Younger age at diagnosis of Ob-APS, additional cardiovascular risk factors, superficial vein thrombosis, heart valve disease, and multiple aPL positivity increased the risk of first thrombosis after PM. Women with thrombosis after PM had a higher aGAPSS compared with women with Ob-APS alone [median 11.5 (4-16) versus 9 (4-13); P = 0.0089]. Conclusion Based on a retrospective analysis of our multicentre aPL database, 63% of women with Ob-APS developed thrombosis after initial obstetric morbidity; additional thrombosis risk factors, selected clinical manifestations, and high-risk aPL profile increased the risk. Women with subsequent thrombosis after Ob-APS had a higher aGAPSS at entry to the registry. We believe that aGAPSS is a valid tool to improve risk stratification in aPL-positive women.
conferenceObject The Clinical and Laboratory Characteristics of Antiphospholipid Antibody Positive Patients Included in the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (""Registry"")(2019) SEVIM, Ecem; ZISA, Diane; ANDRADE, Danieli; PENGO, Vittorio; SCIASCIA, Savino; TEKTONIDOU, Maria; UGARTE, Amaia; GEROSA, Maria; BELMONT, H. Michael; PEDRERA, Rosario Lopez; JI, Lanlan; FORTIN, Paul; EFTHYMIOU, Maria; JESUS, Guilherme De; BRANCH, David; ANDREOLI, Laura; PETRI, Michelle; CERVERA, Ricard; RODRIGUEZ, Esther; KNIGHT, Jason; ATSUMI, Tatsuya; WILLIS, Rohan; BERTOLACCINI, Maria Laura; COHEN, Hannah; ROUBEY, Robert; ERKAN, Doruk; BARBHAIYA, MedhaconferenceObject Descriptive Analysis of Biopsy-proven Antiphospholipid Antibody-associated Nephropathy Patients Included in the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (""Registry"")(2019) TAGHAVI, Maxime; BARBHAIYA, Medha; TEKTONIDOU, Maria; FORTIN, Paul; ANDRADE, Danieli; KNIGHT, Jason; ARTIMESEN, Bahar; ATSUMI, Tatsuya; COHEN, Hannah; JI, Lanlan; SCIASCIA, Savino; SESHAN, Surya; ERKAN, DorukconferenceObject Comparison of Local and Core Laboratory Lupus Anticoagulant Results from the APS ACTION Database/Repository(2019) EFTHYMIOU, Maria; MACKIE, Ian; LANE, Philip; ANDRADE, Danielli; WILLIS, Rohan; KRILLIS, Steven; ERKAN, Doruk; SCIASCIA, Savino; BERTOLACCINI, Laura; PENGO, Vittorio; COHEN, Hannah- Systemic sclerosis induced by the use of cocaine: is there an association?(2019) ANDREUSSI, Rafael; SILVA, Lila Morena Bueno; SILVA, Henrique Carrico da; LUPPINO-ASSAD, Ana Paula; ANDRADE, Danieli Castro O.; SAMPAIO-BARROS, Percival D.The association between cocaine abuse and systemic sclerosis (SSc) is rarely described. Two new cases of this association are presented: two young adults, after using inhaled cocaine for a few years, were diagnosed with SSc. While a 24 year-old white female patient presented with diffuse SSc with multiple digital ulcers and scleroderma renal crisis (SRC), a 27 year-old male patient presented limited SSc with skin ulcers and digital gangrene, rapidly evolving to death due to massive intestinal hemorrhage. The authors performed a literature search and found only eight previously published cases. The clinical picture of these patients shows a predominance of vascular involvement, including multiple ulcers and SRC. There is no association with specific SSc autoantibodies. The concomitance of alcohol and other drugs abuse, as well as the presence of drug adulterers, complicates a clear understanding of the role of cocaine in SSc patients.
conferenceObject HIGH INCIDENCE OF OSTEOPOROTIC FRACTURES IN A SINGLE COHORT OF 700 PATIENTS WITH SYSTEMIC SCLEROSIS(2019) SAMPAIO-BARROS, Marilia; BORTOLUZZO, Adriana; SILVA, Henrique Carrico da; LUPPINO-ASSAD, Ana Paula; ANDRADE, Danieli; PEREIRA, Rosa Maria; SAMPAIO-BARROS, Percival
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