JOSE PONTES JUNIOR

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 42 Citação(ões) na Scopus
    A prognostic model for survival after palliative urinary diversion for malignant ureteric obstruction: a prospective study of 208 patients
    (2016) CORDEIRO, Maurcio D.; COELHO, Rafael F.; CHADE, Daher C.; PESSOA, Rodrigo R.; CHAIB, Mateus S.; COLOMBO-JUNIOR, Jose R.; PONTES-JUNIOR, Jose; GUGLIELMETTI, Giuliano B.; SROUGI, Miguel
    Objective To identify factors associated with survival after palliative urinary diversion (UD) for patients with malignant ureteric obstruction (MUO) and create a risk-stratification model for treatment decisions. Patients and Methods We prospectively collected clinical and laboratory data for patients who underwent palliative UD by ureteric stenting or percutaneous nephrostomy (PCN) between 1 January 2009 and 1 November 2011 in two tertiary care university hospitals, with a minimum 6-month follow-up. Inclusion criteria were age >18 years and MUO confirmed by computed tomography, ultrasonography or magnetic resonance imaging. Factors related to poor prognosis were identified by Cox univariable and multivariable regression analyses, and a risk stratification model was created by Kaplan-Meier survival estimates at 1, 6 and 12 months, and log-rank tests. Results The median (range) survival was 144 (0-1084) days for the 208 patients included after UD (58 ureteric stenting, 150 PCN); 164 patients died, 44 (21.2%) during hospitalisation. Overall survival did not differ by UD type (P = 0.216). The number of events related to malignancy (>= 4) and Eastern Cooperative Oncology Group (ECOG) index (> 2) were associated with short survival on multivariable analysis. These two risk factors were used to divide patients into three groups by survival type: favourable (no factors), intermediate (one factor) and unfavourable (two factors). The median survival at 1, 6, and 12 months was 94.4%, 57.3% and 44.9% in the favourable group; 78.0%, 36.3%, and 15.5% in the intermediate group; and 46.4%, 14.3%, and 7.1% in the unfavourable group (P < 0.001). Conclusions Our stratification model may be useful to determine whether UD is indicated for patients with MUO.
  • conferenceObject
    THE PHENOMENON OF EPITHELIAL-MESENCHYMAL TRANSITION IS ASSOCIATED WITH THE PROGRESSION OF PROSTATE CANCER
    (2016) PONTES JR., Jose; COELHO, Rafael; CORDEIRO, Mauricio; BETONI, Giuliano; OLIVEIRA, Luiz; REIS, Sabrina; LEITE, Katia; SROUGI, Miguel; NAHAS, William
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    PROSPECTIVE RANDOMIZED TRIAL COMPARING OPEN TO LAPAROSCOPIC PARTIAL NEPHRECTOMY, INTERIM ANALYSIS. (NCT01809119)
    (2016) GUGLIELMETTI, Giuliano; ADONIAS, Sanarelly; COELHO, Rafael; CORDEIRO, Mauricio; BORGES, Leonardo; COLOMBO, Jose Roberto; PESSOA, Rodrigo; NEVES, Luiz; PONTES, Jose; NESRALLAH, Adriano; SROUGI, Miguel; NAHAS, William
  • article 5 Citação(ões) na Scopus
    Role of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer
    (2016) REIS, Sabrina T.; VIANA, Nayara I.; LEITE, Katia R. M.; DIOGENES, Erico; ANTUNES, Alberto A.; ISCAIFE, Alexandre; NESRALLAH, Adriano J.; PASSEROTTI, Carlo C.; SROUGI, Victor; PONTES-JUNIOR, Jose; SALLES, Mary Ellen; NAHAS, William C.; SROUGI, Miguel
    Backgrounds Our aim was to evaluate the role of 20 genetic polymorphisms in the development and prognosis of sporadic and familial PC. A case-control study of 185 patients who underwent radical prostatectomy from 1997 to 2011. These patients were divided into two groups based on their family history. Gleason grade, PSA value and pathological TNM 2002 stage were used as prognostic factors. Blood samples from 70 men without PC were used as controls. The SNPs were genotyped using a TaqMan SNP Genotyping Assay Kit. Results Considering susceptibility, the polymorphic allele in the SNP rs2660753 on chromosome 3 was significantly more prevalent in controls (p = 0.01). For familial clustering, the polymorphic homozygote genotype of the SNP rs7931342 was five times more frequent in patients with familial PC compared to sporadic PC (p = 0.01). Regarding the SNP 1447295, the polymorphic homozygote genotype was more prevalent in patients with organ-confined PC (p = 0.05), and most importantly, the polymorphic allele occurred more frequently in patients without biochemical recurrence (p = 0.01). Kaplan-Meier analysis showed a median biochemical recurrence free survival of 124.2 compared to 85.6 months for patients with the wild-type allele (p = 0.007). Conclusion Our findings provide the evidence for the association of 20 recently highlighted SNPs and their susceptibility, familial clustering, staging, Gleason score and biochemical recurrence of PC. We believe that the association between these SNPs and PC may contribute to the development of alternative tools that can facilitate the early detection and prognosis of this disease.
  • conferenceObject
    Expression of miRNAs 200c and 33a That Negatively Control HAS2 and HAS3 in Localized Prostate Cancer
    (2016) MOURA, Caio M.; REIS, Sabrina T.; PONTES, Jose; VIANA, Nayara; DIP, Nelson; SROUGI, Miguel; LEITE, Katia R. M.
  • conferenceObject
    Expression of miRNAs 200c and 33a That Negatively Control HAS2 and HAS3 in Localized Prostate Cancer
    (2016) MOURA, Caio M.; REIS, Sabrina T.; PONTES, Jose; VIANO, Nayara; DIP, Nelson; SROUGI, Miguel; LEITE, Katia R. M.
  • conferenceObject
    TESTOSTERONE LEVELS AS A PREDICTOR FACTOR OF AGRESSIVE DISEASE IN PATIENTS WITH PROSTATE CANCER SUBMITTED TO RADICAL PROSTATECTOMY
    (2016) ALBUQUERQUE, George A. M. Lins de; GUGLIELMETTI, Giuliano B.; PONTES JR., Jose; LOCALI, Rafael; COELHO, Rafael F.; CURY, Jose; SROUGI, Miguel; NAHAS, Wiliam C.
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    ANGIOGENESIS RELATED MICRORNAS AND GENE EXPRESSION PROFILE IN RENAL CELL CARCINOMA, CLEAR CELL TYPE
    (2016) OLIVEIRA, Rita de Cassia; VIANA, Nayara; LEITE, Katia; GUIMARAES, Vanessa; PONTES, Jose; LVANOVIC, Renato; MOURA, Caio; REIS, Denis; DIP, Nelson; NAHAS, William; SROUGI, Miguel; REIS, Sabrina