FLAIR JOSE CARRILHO

(Fonte: Lattes)
Índice h a partir de 2011
32
Lattes
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Departamento de Gastroenterologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina - Líder

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Agora exibindo 1 - 10 de 13
  • bookPart
    Farmacogenética em oncologia gastrintestinal
    (2017) ANDRADE, Guilherme Marques; CARRILHO, Flair José; ONO, Suzane Kioko
  • bookPart
    Icterícia
    (2016) MOTTA, Marina Pamponet; CARRILHO, Flair José; ONO, Suzane Kioko
  • bookPart
    Tumores hepáticos
    (2017) KIKUCHI, Luciana Oba Onishi; CARRILHO, Flair José; ALVES, Venâncio Avancini Ferreira
  • bookPart 0 Citação(ões) na Scopus
    HCC in patients with NAFLD/NASH
    (2020) STEFANO, J. T.; MALTA, F. De Mello; CAMPOS, P. B. De; ANDRADE, P. F.; PARANAGUá-VEZZOZO, D. C.; CARRILHO, F. J.; OLIVEIRA, C. P.
    Hepatocellular carcinoma (HCC) associated with NAFLD has been steadily increasing and non-alcoholic steatohepatitis (NASH) is the most rapidly growing risk for liver transplantation in patients with HCC in the last years. In the vast majority of cases, HCC develops in the context of hepatic cirrhosis, but recent data suggest that there is a proportion of patients with NAFLD who are at high risk for HCC in the absence of cirrhosis. Although no study clearly explains the evolution of NAFLD to HCC, researchers suggest that the most likely mechanism involves fatty acid (FA) accumulation in hepatocytes due to predisposing factors, such as MtS, increased oxidative stress, endoplasmic reticulum (ER) stress, mitochondrial dysfunction and chronic endotoxaemia. Genetic and epigenetic changes in pathogenesis and hepatic carcinogenesis potentially serve as potential diagnostic biomarkers and/or therapeutic targets. MicroRNAs (miRNAs) play a key role in the pathogenesis of HCC related to NAFLD by closely regulating lipid metabolism, glucose homeostasis, cell proliferation, apoptosis, and cell migration and differentiation. In other words, there are currently no guidelines for the screening and early detection of NAFLD-related HCC in the absence of cirrhosis. However, there is an increasing number of HCC cases without cirrhosis. Thus, there is a strong interest in identifying biomarkers to detect early detection of HCC risk related to NAFLD progression. © Springer Nature Switzerland AG 2020.
  • bookPart
    Carcinoma hepatocelular
    (2014) SILVA, Adávio de Oliveira; WAHLE, Raul Carlos; SOUZA, Evandro de Oliveira; CRUZ, Marcelo Rocha de Souza; CARRILHO, Flair José; CHAGAS, Aline Lopes; KIKUCHI, Luciana Oba Onishi; MUNIZ, Juliana Queiroz Vasconcelos; JESUS, Rosângela Passos de
  • bookPart
    Hepatites Crônicas
    (2016) ONO, Suzane Kioko; ALVES, Venâncio Avancini Ferreira; CARRILHO, Flair José
  • bookPart
    Sistema Digestivo - Estrutura e Função
    (2016) CARLOS, Alexandre de Sousa; CARRILHO, Flair José; MAZO, Daniel Ferraz de Campos; CAMPOS, Felipe Dominguez Henriques de
  • bookPart
    Dor Abdominal
    (2016) CHAGAS, Aline Lopes; CARRILHO, Flair José
  • bookPart
    Doenças Hepáticas Causadas por Bactérias, Parasitas e/ou Fungos
    (2016) CALY, Wanda Regina; FARIAS, Alberto Queiroz; RABELO, Fabiola; BAPTISTA, Daniel Machado; CARRILHO, Flair José
  • bookPart
    Prefácio
    (2017) CARRILHO, Flair José; CECCONELLO, Ivan; D´ALBUQUERQUE, Luiz Augusto Carneiro