BEATRIZ MANGUEIRA SARAIVA RAMANHOLO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Airway inflammatory profile among cleaning workers from different workplaces(2016) FELIX, Soraia Nogueira; AVONA, Monise Dematte; SANTOS, Bruna Gabryela Busoletto dos; PAZ, Edineia Rosa da; ALMEIDA, Francine Maria de; GENARO, Isabella Santos de; LIMA, Cynthia Mafra Fonseca de; GALVAO, Clovis Eduardo Santos; GARCIA, Maria Lucia Bueno; MARTINS, Milton de Arruda; ROMANHOLO, Beatriz Mangueira Saraiva
- Analysis of the inflammatory profile of children with controlled and uncontrolled severe asthma(2016) ELLER, Miriam; VERGANI, Karina; SARAIVA-ROMANHOLO, Beatriz; ANTONANGELO, Leila; MAUAD, Thais; RODRIGUES, Joaquim
conferenceObject A unique session of aerobic exercise does not decrease pulmonary inflammation in a murine mice model of asthma(2012) SILVA, Ronaldo Aparecido da; ALMEIDA, Francine Maria; OLIVO, Clarice Rosa; SARAIVA, Beatriz Mangueira; MARTINS, Milton A.; CARVALHO, Celso Ricardo FernandesconferenceObject Lung inflammation was attenuated by sakuranetin treatment in a model of acute lung injury(2014) MERNAK, Marcia; SANTANA, Fernanda; PINHEIRO, Nathalia; SARAIVA-RAMANHOLO, Beatriz; GRECCO, Simone; TIBERIO, Iolanda; MARTINS, Milton; LAGO, Joao; PRADO, CarlaconferenceObject Essential oils reduced lung inflammation in a model of acute lung injury(2014) GUERREIRO, Marina; MERNAK, Marcia; SANTANA, Fernanda; PINHEIRO, Nathalia; SARAIVA-RAMANHOLO, Beatriz; CAPELLO, Tabata; TIBERIO, Iolanda; MARTINS, Milton; LAGO, Joao; PRADO, Carla- The effects of exercise training on the lungs and cardiovascular function of animals exposed to diesel exhaust particles and gases(2022) OLIVO, C. R.; CASTRO, T. B. P.; RIANE, A.; REGONHA, T.; RIVERO, D. H. R. F.; VIEIRA, R. P.; SARAIVA-ROMANHOLO, B. M.; LOPES, F. D. T. Q. S.; TIBERIO, I. F. L. C.; MARTINS, M. A.; PRADO, C. M.Air pollution has been identified as one of the main environmental risks to health. Since exercise training seems to act as an anti-inflammatory modulator, our hypothesis is that exercise training prevents damage to respiratory and cardiovascular function caused by diesel exhaust particle (DEP) exposure. This study aimed to evaluate whether aerobic exercise training prior to DEP exposure prevents inflammatory processes in the pulmonary and cardiovascular systems. Therefore, BALB/C male mice were or were not submitted to a 10-week exercise training protocol (5x/week, 1 h/d), and after four weeks, they were exposed to DEP in a chamber with 24 mu g/m3 PM2.5 or filtered air. Heart rate variability, lung mechanics and bronchoalveolar lavage fluid, cytokines and polymorphonuclear cells in the lung parenchyma were evaluated. Exposure to DEPs reduced heart rate variability and the elastance of the respiratory system and increased the number of cells in bronchoalveolar lavage fluid, as well as macrophages, neutrophils and lymphocytes, the density of polymorphonuclear cells and the proportion of collagen fibres in the lung parenchyma. Additionally, DEP-exposed animals showed increased expression of IL-23 and IL-12p40 (proinflammatory cytokines) and inducible nitric oxide synthase. Exercise training avoided the increases in all these inflammatory parameters, except the elastance of the respiratory system, the amount of collagen fibres and the expression of inducible nitric oxide synthase. Additionally, trained animals showed increased expression of the anti-inflammatory cytokine IL-1ra. Although our data showed a reduction in proinflammatory markers and an increase in markers of the anti-inflammatory pathway, these changes were not sufficient to prevent damage to the lung and cardiovascular function induced by DEPs. Based on these data, we propose that aerobic exercise training prevents the lung inflammatory process induced by DEPs, although it was not sufficient to avoid chronic damage, such as a loss of lung function or cardiovascular events.
- Effects of acute hypochlorite exposure in OVA-sensitized and challenged mice(2015) GENARO, Isabella S. de; ALMEIDA, Francine M. de; HIZUME, Deborah; MORIYA, Henrique T.; CORDEIRO, Bruna N.; CRUZ, Joao Carlos G.; LOPES, Renan B.; VIEIRA, Rodolfo P.; SILVA, Ronaldo A.; MARTINS, Milton A.; ARANTES-COSTA, Fernanda M.; SARAIVA-ROMANHOLO, Beatriz M.
- Cigarette smoke dissociates inflammation and lung remodeling in OVA-sensitized and challenged mice(2012) HIZUME, Deborah C.; TOLEDO, Alessandra C.; MORIYA, Henrique T.; SARAIVA-ROMANHOLO, Beatriz M.; ALMEIDA, Francine M.; ARANTES-COSTA, Fernanda M.; VIEIRA, Rodolfo P.; DOLHNIKOFF, Marisa; KASAHARA, David Itiro; MARTINS, Milton A.We evaluated the effects of cigarette smoke (CS) on lung inflammation and remodeling in a model of ovalbumin (OVA)-sensitized and OVA-challenged mice. Male BALB/c mice were divided into 4 groups: non-sensitized and air-exposed (control); non-sensitized and exposed to cigarette smoke (CS), sensitized and air-exposed (OVA) (50 mu g + OVA 1% 3 times/week for 3 weeks) and sensitized and cigarette smoke exposed mice (OVA + CS). IgE levels were not affected by CS exposure. The increases in total bronchoalveolar fluid cells in the OVA group were attenuated by co-exposure to CS, as were the changes in IL-4, IL-5, and eotaxin levels as well as tissue elastance (p < 0.05). In contrast, only the OVA + CS group showed a significant increase in the protein expression of IFN-gamma, VEGF, GM-CSF and collagen fiber content (p < 0.05). In our study, exposure to cigarette smoke in OVA-challenged mice resulted in an attenuation of pulmonary inflammation but led to an increase in pulmonary remodeling and resulted in the dissociation of airway inflammation from lung remodeling.
- Effects of sodium hypochlorite and cigarette smoke on lung function and behavior of Wistar rats(2016) FELIX, Soraia Nogueira; PANDOLPHO, Renata; MOREIRA, Andrezza Luiza; MACENCO, Isabela Campaner; BENITTES, Larissa Baptista; ALMEIDA, Francine Maria de; GENARO, Isabella Santos de; ARANTES, Fernanda; MARTINS, Milton de Arruda; XAVIER, Gilberto Fernando; TIBERIO, Iolanda de Fatima Lopes Calvo; ROMANHOLO, Beatriz Mangueira Saraiva
conferenceObject Exhaled nitric oxide in traffic professionals exposed to ambient urban air pollution(2012) OSHIRO, Claudia; KOGISO, Diogo; ROMANHOLO, Beatriz; MARTINS, Lourdes; BRAGA, Alfesio; SALDIVA, Paulo; GARCIA, Maria