JOSE ELUF NETO
Projetos de Pesquisa
Unidades Organizacionais
LIM/38 - Laboratório de Epidemiologia e Imunobiologia, Hospital das Clínicas, Faculdade de Medicina - Líder
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Using Prior Information from the Medical Literature in GWAS of Oral Cancer Identifies Novel Susceptibility Variant on Chromosome 4-the AdAPT Method(2012) JOHANSSON, Mattias; ROBERTS, Angus; CHEN, Dan; LI, Yaoyong; DELAHAYE-SOURDEIX, Manon; ASWANI, Niraj; GREENWOOD, Mark A.; BENHAMOU, Simone; LAGIOU, Pagona; HOLCATOVA, Ivana; RICHIARDI, Lorenzo; KJAERHEIM, Kristina; AGUDO, Antonio; CASTELLSAGUE, Xavier; MACFARLANE, Tatiana V.; BARZAN, Luigi; CANOVA, Cristina; THAKKER, Nalin S.; CONWAY, David I.; ZNAOR, Ariana; HEALY, Claire M.; AHRENS, Wolfgang; ZARIDZE, David; SZESZENIA-DABROWSKA, Neonilia; LISSOWSKA, Jolanta; FABIANOVA, Eleonora; MATES, Ioan Nicolae; BENCKO, Vladimir; FORETOVA, Lenka; JANOUT, Vladimir; CURADO, Maria Paula; KOIFMAN, Sergio; MENEZES, Ana; WUENSCH-FILHO, Victor; ELUF-NETO, Jose; BOFFETTA, Paolo; FRANCESCHI, Silvia; HERRERO, Rolando; GARROTE, Leticia Fernandez; TALAMINI, Renato; BOCCIA, Stefania; GALAN, Pilar; VATTEN, Lars; THOMSON, Peter; ZELENIKA, Diana; LATHROP, Mark; BYRNES, Graham; CUNNINGHAM, Hamish; BRENNAN, Paul; WAKEFIELD, Jon; MCKAY, James D.Background: Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by incorporating complementary data. In this study we investigated the feasibility of automatically retrieving information from the medical literature and leveraging this information in GWAS. Methods: We developed a method that searches through PubMed abstracts for pre-assigned keywords and key concepts, and uses this information to assign prior probabilities of association for each single nucleotide polymorphism (SNP) with the phenotype of interest - the Adjusting Association Priors with Text (AdAPT) method. Association results from a GWAS can subsequently be ranked in the context of these priors using the Bayes False Discovery Probability (BFDP) framework. We initially tested AdAPT by comparing rankings of known susceptibility alleles in a previous lung cancer GWAS, and subsequently applied it in a two-phase GWAS of oral cancer. Results: Known lung cancer susceptibility SNPs were consistently ranked higher by AdAPT BFDPs than by p-values. In the oral cancer GWAS, we sought to replicate the top five SNPs as ranked by AdAPT BFDPs, of which rs991316, located in the ADH gene region of 4q23, displayed a statistically significant association with oral cancer risk in the replication phase (per-rare-allele log additive p-value [p(trend)] = 2.5 x 10(-3)). The combined OR for having one additional rare allele was 0.83 (95% CI: 0.76-0.90), and this association was independent of previously identified susceptibility SNPs that are associated with overall UADT cancer in this gene region. We also investigated if rs991316 was associated with other cancers of the upper aerodigestive tract (UADT), but no additional association signal was found. Conclusion: This study highlights the potential utility of systematically incorporating prior knowledge from the medical literature in genome-wide analyses using the AdAPT methodology. AdAPT is available online (url: http://services.gate.ac.uk/lld/gwas/service/config).
- Ethnicity and Cutaneous Melanoma in the City of Sao Paulo, Brazil: A Case-Control Study(2012) LUIZ, Olinda C.; GIANINI, Reinaldo Jose; GONCALVES, Fernanda T.; FRANCISCO, Guilherme; FESTA-NETO, Cyro; SANCHES, Jose Antonio; GATTAS, Gilka J. F.; CHAMMAS, Roger; ELUF-NETO, JoseBackground: Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogenous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil. Methodology/Principal Findings: We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), or >= 2 European countries (OR = 2.82, 95% CI: 1.06-7.47); eye color-light brown (OR = 1.99, 95% CI: 1.14-3.84) and green/blue (OR = 4.62; 95% CI 2.22-9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21-6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03-9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03-3.19). Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants.
- A School-Based Human Papillomavirus Vaccination Program in Barretos, Brazil: Final Results of a Demonstrative Study(2013) FREGNANI, Jose Humberto Tavares Guerreiro; CARVALHO, Andre Lopes; ELUF-NETO, Jose; RIBEIRO, Karina de Cassia Braga; KUIL, Larissa de Melo; SILVA, Tauana Arcadepani da; RODRIGUES, Silvia Lapola; MAUAD, Edmundo Carvalho; LONGATTO-FILHO, Adhemar; VILLA, Luisa LinaIntroduction: The implementation of a public HPV vaccination program in several developing countries, especially in Latin America, is a great challenge for health care specialists. Aim: To evaluate the uptake and the three-dose completion rates of a school-based HPV vaccination program in Barretos (Brazil). Methods: The study included girls who were enrolled in public and private schools and who regularly attended the sixth and seventh grades of elementary school (mean age: 11.9 years). A meeting with the parents or guardians occurred approximately one week before the vaccination in order to explain the project and clarify the doubts. The quadrivalent vaccine was administered using the same schedule as in the product package (0-2-6 months). The school visits for regular vaccination occurred on previously scheduled dates. The vaccine was also made available at Barretos Cancer Hospital for the girls who could not be vaccinated on the day when the team visited the school. Results: Among the potential candidates for vaccination (n = 1,574), the parents or guardians of 1,513 girls (96.1%) responded to the invitation to participate in the study. A total of 1,389 parents or guardians agreed to participate in the program (acceptance rate = 91.8%). The main reason for refusing to participate in the vaccination program was fear of adverse events. The vaccine uptake rates for the first, second, and third doses were 87.5%, 86.3% and 85.0%, respectively. The three-dose completion rate was 97.2%. Conclusions: This demonstrative study achieved high rates of vaccination uptake and completion of three vaccine doses in children 10-16 years old from Brazil. The feasibility and success of an HPV vaccination program for adolescents in a developing country may depend on the integration between the public health and schooling systems.
- The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract(2015) DELAHAYE-SOURDEIX, Manon; OLIVER, Javier; TIMOFEEVA, Maria N.; GABORIEAU, Valerie; JOHANSSON, Mattias; CHABRIER, Amelie; WOZNIAK, Magdalena B.; BRENNER, Darren R.; VALLEE, Maxime P.; ANANTHARAMAN, Devasena; LAGIOU, Pagona; HOLCATOVA, Ivana; RICHIARDI, Lorenzo; KJAERHEIM, Kristina; AGUDO, Antonio; CASTELLSAGUE, Xavier; MACFARLANE, Tatiana V.; BARZAN, Luigi; CANOVA, Cristina; THAKKER, Nalin S.; CONWAY, David I.; ZNAOR, Ariana; HEALY, Claire M.; AHRENS, Wolfgang; ZARIDZE, David; SZESZENIA-DABROWSKA, Neonilia; LISSOWSKA, Jolanta; FABIANOVA, Eleonora; MATES, Ioan Nicolae; BENCKO, Vladimir; FORETOVA, Lenka; JANOUT, Vladimir; CURADO, Maria Paula; KOIFMAN, Sergio; MENEZES, Ana; WUENSCH-FILHO, Victor; ELUF-NETO, Jose; BOFFETTA, Paolo; GARROTE, Leticia Fernandez; SERRAINO, Diego; LENER, Marcin; JAWOROWSKA, Ewa; LUBINSKI, Jan; BOCCIA, Stefania; RAJKUMAR, Thangarajan; SAMANT, Tanuja A.; MAHIMKAR, Manoj B.; MATSUO, Keitaro; FRANCESCHI, Silvia; BYRNES, Graham; BRENNAN, Paul; MCKAY, James D.Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
- The Role of School Environment in Physical Activity among Brazilian Adolescents(2015) REZENDE, Leandro Fornias Machado de; AZEREDO, Catarina Machado; SILVA, Kelly Samara; CLARO, Rafael Moreira; FRANCA-JUNIOR, Ivan; PERES, Maria Fernanda Tourinho; LUIZ, Olinda do Carmo; LEVY, Renata Bertazzi; ELUF-NETO, JoseObjective To analyze the association of physical activity facilities and extracurricular sports activities in schools with physical activity among adolescents. Methodology/Principal Findings We used data collected for the National Survey of School Health in 2012. The national representative sample comprised 109,104 Brazilian students from 2,842 schools. We calculated the prevalence of participation in physical education classes, leisure-time physical activity, and total physical activity level. We also evaluated the following physical activity facilities: sports courts, running/athletics tracks, schoolyard with teacher-directed physical activities, swimming pools, locker rooms; and the offer of extracurricular sports activities. Schools with at least one physical activity facility had increased odds of participation in physical education (OR 1.59; 95% CI 1.20 to 2.10). However, in order to increase leisure-time physical activity (OR 1.14; 95% CI 1.03 to 1.26) and total physical activity level (OR 1.15; 95% CI 1.06 to 1.24) at least four and two facilities, respectively, were necessary. Extracurricular sports activities in schools were positively associated with leisure-time physical activity and physical activity level. The number of sports courts and swimming pool in a school were associated with participation in physical education classes. Availability of sports courts, running/athletics tracks, and swimming pool in schools were associated with leisure-time physical activity. Total physical activity was associated with schools with sports courts, schoolyard with teacher-directed physical activities, and swimming pool. Conclusions School-level characteristics have important potential to increase the possibility of engagement in physical activity in and out of school, and therefore have a fundamental role in promoting these practices.