MARIA ADELAIDE ALBERGARIA PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
5 resultados
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bookPart Feocromocitomas e Paragangliomas(2016) PEREIRA, Maria Adelaide Albergaria; FREIRE, Daniel Soares- Presentation and surgery outcomes in elderly with pheocromocytoma: a comparative analysis with young patients(2016) SROUGI, Victor; CHAMBO, Jose L.; TANNO, Fabio Y.; SOARES, Iracy S.; ALMEIDA, Madson Q.; PEREIRA, Maria A. A.; SROUGI, Miguel; FRAGOSO, Maria C.Purpose: To evaluate the presentation and early surgical outcomes of elderly patients undergoing adrenalectomy for phaeochromocytoma. Patients and Methods: A retrospective search was performed of our adrenal disorders database for patients who underwent surgery for phaeochromocytoma or paraganglioma between 2009 and 2014. Patients > 60 years old were classified as elderly. The clinical manifestations, intraoperative course, and early postoperative outcomes of elderly patients were compared to those of younger individuals (< 60 years old). Results: The mean (+/- standard deviation) age in the older (n= 10) and younger (n= 36) groups was 69.6 +/- 5.3 years and 34.0 +/- 12.9 years. Germ-line mutations were more common in younger patients (50.0% versus 0%; p=0.004), whereas incidental lesions were more common in the elderly (40.0% versus 5.3%; p=0.003). In both groups, surgery was most commonly performed by videolaparoscopy (90% in the elderly and 82% in the younger group), with similar intraoperative anesthetic and surgical outcomes. Post-operatively, the older group more commonly received vasoactive drugs (60.0% versus 10.5%; p<0.001) and had a longer intensive care unit stay (3.1 +/- 2.8 versus 1.4 +/- 1.0 days; p= 0.014), more clinical complications (60% versus 18.9%; p= 0.01), and longer hospital stay (10.2 +/- 8.4 versus 5.7 +/- 4.9 days; p= 0.028). Conclusions: Although all patients received the same preoperative preparation, the elderly group exhibited a slower and more complicated recovery after adrenalectomy. Meticulous perioperative care should be used in the elderly when treating phaeochromocytoma; nevertheless, adrenalectomy is a relatively safe procedure in this patient population.
- Refractory hypoglycemia in a patient with functional adrenal cortical carcinoma(2016) MARCHETTI, Katia Regina; PEREIRA, Maria Adelaide Albergaria; LICHTENSTEIN, Arnaldo; PAIVA, Edison FerreiraAdrenacarcinomas are rare, and hypoglycemic syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by these tumors have been described infrequently. This study describes the case of a young woman with severe persistent hypoglycemia and a large adrenal tumor and discusses the physiopathological mechanisms involved in hypoglycemia. The case is described as a 21-year-old woman who presented with 8 months of general symptoms and, in the preceding 3 months, with episodes of mental confusion and visual blurring secondary to hypoglycemia. A functional assessment of the adrenal cortex revealed ACTH-independent hypercortisolism and hyperandrogenism. Hypoglycemia, hypoinsulinemia, low C-peptide and no ketones were also detected. An evaluation of the GH-IGF axis revealed GH blockade (0.03; reference: up to 4.4 ng/mL), greatly reduced IGF-I levels (9.0 ng/mL; reference: 180-780 ng/mL), slightly reduced IGF-II levels (197 ng/mL; reference: 267-616 ng/mL) and an elevated IGF-II/IGF-I ratio (21.9; reference: similar to 3). CT scan revealed a large expansive mass in the right adrenal gland and pulmonary and liver metastases. During hospitalization, the patient experienced frequent difficult-to-control hypoglycemia and hypokalemia episodes. Octreotide was ineffective in controlling hypoglycemia. Due to unresectability, chemotherapy was tried, but after 3 months, the patient's condition worsened and progressed to death. In conclusion, our patient presented with a functional adrenal cortical carcinoma, with hyperandrogenism associated with hypoinsulinemic hypoglycemia and blockage of the GH-IGF-I axis. Patient's data suggested a diagnosis of hypoglycemia induced by an IGF-II or a large IGF-II-producing tumor (low levels of GH, greatly decreased IGF-I, slightly decreased IGF-II and an elevated IGF-II/IGF-I ratio).
bookPart Abordagem dos Pacientes com Endocrinopatias(2016) PEREIRA, Maria Adelaide AlbergariabookPart Insuficiência Adrenal(2016) BRANDãO NETO, Rodrigo Antonio; PEREIRA, Maria Adelaide Albergaria