JANE OBA
Projetos de Pesquisa
Unidades Organizacionais
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
23 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 23
- Fatal Presentation of Thrombotic Cutaneous Gangrene Associated With Acute Severe Colitis(2023) BARROS, Luisa Leite; PRADO, Rita de Cassia Parente; FERREIRA, Lucas Fortes Portela; AZEVEDO, Matheus Freitas Cardoso de; OBA, Jane; CARLOS, Alexandre de Souza; DAMIAO, Aderson Omar Mourao Cintra
- Anti-TNF Therapy in Elderly Patients With Inflammatory Bowel Disease in a Tuberculosis-Endemic Country(2023) BARROS, Luisa Leite; AZEVEDO, Matheus Freitas Cardoso de; CARLOS, Alexandre de Souza; LOPES, Paula De Azevedo; FUJITA, Andre Okuhara; BRITO, Daniela Sanches; KAMADA, Daniela Midori; PRADO, Rita de Cassia Parente; ANDRADE, Julia Carvalho De; OBA, Jane; DAMIAO, Aderson Omar Mourao Cintra
- Prevalence of dysplasia and colorectal cancer in Ulcerative Colitis patients from a referral center in Latin America(2021) JUNIOR, R. S. F.; CARVALHO, M. F.; SILVA, J. C.; BARROS, L. L.; AZEVEDO, M. F. C.; CARLOS, A. D. S.; OBA, J.; HASHIMOTO, C. L.; CANCADO, E. L. R.; DAMIAO, A. O. M. C.; SIPAHI, A. M.
- Efficacy of Early Optimization of Infliximab Guided by Therapeutic Drug Monitoring during Induction-A Prospective Trial(2023) GARCIA, Karoline Soares; AZEVEDO, Matheus Freitas Cardoso de; CARLOS, Alexandre de Sousa; BARROS, Luisa Leite; OBA, Jane; SOBRADO JUNIOR, Carlos Walter; SIPAHI, Aytan Miranda; ALVES, Olivia Duarte de Castro; NAVARRO-RODRIGUEZ, Tomas; PARRA, Rogerio Serafim; CHEBLI, Julio Maria Fonseca; CHEBLI, Liliana Andrade; FLORES, Cristina; VIEIRA, Andrea; CEARA, Christianne Damasceno Arcelino do; QUEIROZ, Natalia Sousa Freitas; DAMIAO, Aderson Omar Mourao CintraTherapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response to these biologics and avoid undesired outcomes related to inadequate drug exposure. This study aimed to describe clinical, biological, and endoscopic remission rates at six months in Brazilian inflammatory bowel disease (IBD) patients following a proactive TDM algorithm guided by IFX trough levels (ITL) and antibodies to IFX (ATI) levels during induction, at week six. A total of 111 IBD patients were prospectively enrolled, excluding those previously exposed to the drug. ITL & GE; 10 & mu;g/mL was considered optimal. Patients with suboptimal ITL (<10 & mu;g/mL) were guided according to ATI levels. Those who presented ATI & LE; 200 ng/mL underwent dose intensification in the maintenance phase, and patients with ATI > 200 ng/mL discontinued IFX. In our study, proactive TDM was associated with persistence in the IFX rate at six months of 82.9%. At that time, rates of clinical, biological, and endoscopic remission in patients under IFX treatment were 80.2%, 73.9%, and 48.1%, respectively. Applying a simplified TDM-guided algorithm during induction seems feasible and can help improve patients' outcomes in clinical practice.
- Safety of anti-TNF introduction following tuberculosis treatment in Inflammatory Bowel Disease patients in an endemic area(2021) AZEVEDO, M. F. C. D.; JUSTUS, F. F.; LIMA, C. C. G.; GARCIA, K. S.; BARROS, L. L.; OBA, J.; CARLOS, A. D. S.; MILANI, L. R.; SIPAHI, A. M.; DAMIAO, A. O. M. C.; QUEIROZ, N. S. F.
bookPart Avaliação da inflamação do trato gastrointestinal(2023) LIMA, Lívia Maria Lindoso; BIBAS, Mariana Deboni; OBA, Jane; JR, Alvaro PulchinellibookPart Dor abdominal(2021) OBA, JaneconferenceObject Inflammatory Bowel Diseases and Autoimmune Hepatitis: Is Anti-TNF Therapy an Option?(2019) ROCHA, Beatriz; QUEIROZ, Natalia; AZEVEDO, Matheus; ALEXANDRE, Carlos; MILANI, Luciane; CANCADO, Eduardo; TERRABUIO, Debora; BARROS, Luisa; OBA, Jane; LEITE, Andre; SIPAHI, Aytan; DAMIAO, Aderson- Autologous haematopoietic stem cell transplantation in refractory Crohn's disease: experience of a Brazilian tertiary centre(2019) OBA, J.; STEINWURZ, F.; SCANAVINI NETO, A.; AMBROGINI, O.; SILVA, C.; NAKASHIMA, S.; SANTOS, M.; HAMERSCHLAK, N.
- Clinical outcomes of refractory Crohn's disease following hematopoietic stem cell transplantation: A single center experience(2019) NATALIA, Queiroz; LUISA, Barros; MATHEUS, Azevedo; ALEXANDRE, Carlos; LUCIANE, Milani; BEATRIZ, Rocha; JANE, Oba; ANDRE, Leite; AYTAN, Sipahi; ADERSON, Damiao
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