MARCELLO MENTA SIMONSEN NICO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
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- Aphthae(2023) FERNANDES, J. D.; NICO, M. M. S.Aphthosis is an inflammatory disease characterized by painful, recurrent oral ulcerations. The cause of aphthosis is unknown, and several studies indicate a role of the immune system in the physiopathogenesis of this disease. Oral lesions mainly appear on the non-keratinized mucosa as painful, regular, round, or oval ulcers covered by a gray pseudomembrane and surrounded by an erythematous halo. The diagnosis of aphthosis is mainly established on clinical grounds. Treatment depends on the severity, recurrence rate, and response to previous therapies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
- Delusional infestation caused by pramipexole(2018) SANDOVAL, K. Romero; FESTA NETO, C.; NICO, M. M. S.
conferenceObject Preliminary Proteomic Analysis of Saliva from Patients with Sjogren's Syndrome(2015) BOLOGNA, S. B.; SOUZA, M. M.; NUNES, T. B.; NICO, M. M. S.; PASOTO, S. G.; LOURENCO, S. V.- Extensive scalp ulcer secondary to delusional infestation treated with antipsychotics and scalp reconstruction(2020) PINCELLI, M. S.; GUIMARARES, A. L. M.; MILCHESKI, D. A.; DWAN, A. J.; NICO, M. M. S.
- Reflectance confocal microscopy as a new tool in the in vivo evaluation of desquamative gingivitis: patterns in mucous membrane pemphigoid, pemphigus vulgaris and oral lichen planus(2013) ALESSI, S. S.; NICO, M. M. S.; FERNANDES, J. D.; LOURENCO, S. V.Background Desquamative gingivitis refers to a clinical manifestation associated with several mucocutaneous disorders. The most common are mucous membrane pemphigoid, pemphigus vulgaris and lichen planus. Their specific diagnosis is better established by histopathological and immunofluorescence evaluation. Objectives To examine cases of desquamative gingivitis using reflectance confocal microscopy (RCM) and compare the findings with those of normal gingiva. To compare RCM findings in desquamative gingivitis with conventional histopathology of the biopsied lesions, in order to establish criteria for this noninvasive diagnostic technique. Methods A total of 25 cases of suspected mucous membrane pemphigoid, pemphigus vulgaris and lichen planus were included. RCM was performed on the gingiva of a healthy person and on gingival lesions. All lesions were biopsied in order to perform a RCM-histopathological correlation. Results Reflectance confocal microscopy examination of the gingival lesions suspected to be mucous membrane pemphigoid revealed a separation at the level of the dermal-epidermal junction, filled with small, bright structures interpreted as blood cells. Histopathological and immunofluorescence findings confirmed the diagnosis. For pemphigus vulgaris, RCM features were intraepithelial clefts with round, detached cells interpreted as acantholytic keratinocytes, similar to the histopathological features. Hyperkeratosis and spongiosis associated with infiltration of inflammatory cells, seen as small, bright cells intermingling with the honeycomb keratinocyte epithelial structure, were seen in lichen planus. Mildly bright, round structures interpreted as necrotic keratinocytes and mildly bright, stellate structures, interpreted as melanophages, were also seen in the dermis. These features were present on histopathology, confirming the diagnosis of lichen planus. Conclusion We propose that RCM is a useful tool to help distinguish between the three most common causes of desquamative gingivitis.
- Verrucous carcinoma (oral)(2016) NICO, M. M. S.; LOURENçO, S. V.Verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma with specific clinical and histological features. Oral verrucous carcinoma is usually extensive and difficult to treat with conventional surgical methods. Cryosurgery can be useful in selected cases and under experienced hands. Favored methods include previous reduction of tumor thickness using oral retinoids or methotrexate followed by massive cryosurgical freezing with cryochambers or closed probes. © Springer-Verlag London 2016. All rights reserved.
- The lip in lupus erythematosus(2014) NICO, M. M. S.; BOLOGNA, S. B.; LOURENCO, S. V.Lupus erythematosus (LE) frequently compromises the skin, lips and oral mucosa. There is a large body of medical and dental literature about the cutaneous and mucosal lesions of LE, but very little has been written specifically about labial lupus. The lip has a peculiar anatomical and histological architecture, and LE lesions at this site may have some distinct features. This article reviews the existing data and adds some new concepts to the issue of labial lupus in all of its presentations, comparing such lesions to the well-established characterization of cutaneous LE (in acute, subacute and chronic lesions), and highlighting some special clinical features that may enable a better diagnosis and differential diagnosis of lip diseases.
- Salivary proteomics in lichen planus: A relationship with pathogenesis?(2018) SOUZA, M. M.; FLOREZI, G. P.; NICO, M. M. S.; PAULA, F. de; PAULA, F. M.; LOURENCO, S. V.ObjectivesOral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocyte pathway induce apoptosis with an increase in Th1 and Th17 subtypes cells, triggered by the release of cytokines. This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease. Material and MethodsProteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. The multiplex analysis validation allowed the correlation between the proteins identified and the involved cytokines in Th17 response. ResultsOne hundred and eight proteins were identified in oral lichen planus, of which 17 proteins showed a high interaction between them and indicated an association with the disease. Expression of these proteins was correlated with the triggering of cytokines, more specifically the Th17 cells. ConclusionProteins, such as S100A8, S100A9, haptoglobin, can trigger cytokines and might be associated with a pathological function and antioxidant activities in oral lichen planus.
- Elastosis perforans serpiginosa(2016) SAMORANO, L.; PIMENTEL, E. R. De Almeida; NICO, M. M. S.Elastosis perforans serpiginosa is an uncommon and chronic dermatosis characterized by transepidermal elimination of abnormal elastic fibers originating in the dermis. Diagnosis is based on clinical and histopathologic aspects. Treatment has included various modalities and cryotherapy is one of the effective options. Favored method includes the use of open spray timed spot freeze technique and one to two sessions are usually enough to treat some grouped papules. © Springer-Verlag London 2016. All rights reserved.
- Cheilitis glandularis: immunohistochemical expression of protein water channels (aquaporins) in minor labial salivary glands(2014) NICO, M. M. S.; MELO, J. N.; LOURENCO, S. V.Background Cheilitis glandularis (CG) is a rare condition in which thick saliva is secreted from dilated ostia of swollen minor salivary glands from the lips. Aquaporins (AQPs) are membrane proteins that exhibit channel activity specific for water and small solutes. AQPs are essential for corporal homeostasis, and are widely expressed through human tissues. Most AQPs studies are based on renal and nervous pathophysiology; few involve salivary glands. Some previous investigators hypothesized that minor salivary gland structure and function is normal on CG. Objectives To study possible salivary synthesis alterations in CG, we compared the expression of AQPs present in minor salivary glands in specimens with CG and controls by using immunohistochemistry. Methods Seven cases of CG and three normal controls were studied. Results Intensity and patterns of expression of AQP 1, 2 and 8 differed in CG compared with controls. AQP 4 and 5 (the most important AQP in salivary function) showed identical patterns in CG and controls. Conclusion Our findings suggest that the expression and arguably, function of some of the AQPs may be altered in CG; consequently, water flow mechanism abnormalities with possible alteration in salivary composition seem to occur. External factors (mainly UV rays) seem to play an important role in CG; nonetheless, our findings suggest that there might be some degree of alteration on water transportation.