MARCELLO MENTA SIMONSEN NICO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/06 - Laboratório de Imunopatologia da Esquistossomose e outras Parasitoses, Hospital das Clínicas, Faculdade de Medicina
13 resultados
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conferenceObject Adhesion molecules in primary oral mucosal melanoma: Study of integrins, claudins and immunoglobulins in a series of 35 cases(2012) LOURENCO, S.; BOLOGNA, S.; COUTINHO-CAMILLO, C.; FERNANDES, J.; SANGUEZA, M.; SOARES, F.; MENTA, M.Objective: Primary oral mucosal melanoma is a rare and aggressive tumor. Recent studies have reported a correlation between increased tumor invasion and metastatic phenotype with an altered expression of adhesion molecules profiles. The present study analyzed the expression of integrins, claudins and immunoglobulins in oral mucosal melanomas and correlated results with clinical features of patients. Method: Immunohistochemistry against these molecules was performed in thirty-five cases of primary oral mucosal melanomas organized into “tissue microarray ”and the results were related to clinical and histological features of patients. Results: Some subunits of integrins presented down-regulation and this was associated with vascular invasion. Increased expression of integrin beta3 and immunoglobulin CD166 (ALCAM) was statistically associated with cases with extensive vascular invasion (p <0,05). Lower expression of the immunoglobulin CD54 (ICAM) was associated with cases with extensive necrosis. Most cases with metastasis were negative for immunoglobulin CD66 (CEACAM). Several subunits of claudins showed down-regulation in the cases analyzed, and, although not statistically significant, it showed to be partially related with histological factors of poor prognosis. Conclusion: Altered patterns of adhesion molecules, mainly integrins and immunoglobulin seem to participate in the pathogenesis and outcome of oral mucosal melanomas.conferenceObject Sclerosing lipogranuloma with multiple skin lesions associated with pulmonary involvement and secondary to a factitious disorder-case report and review(2015) TIRICO, Maria; NICO, Marcello; NETO, CyroconferenceObject Preliminary Proteomic Analysis of Saliva from Patients with Sjogren's Syndrome(2015) BOLOGNA, S. B.; SOUZA, M. M.; NUNES, T. B.; NICO, M. M. S.; PASOTO, S. G.; LOURENCO, S. V.conferenceObject IgG4-related disease: Salivary glands peculiarities and differences with Sjogren's Syndrome(2014) BOLOGNA, S.; NUNES, T.; COUTINHO-CAMILLO, C.; PASOTO, S.; MACHADO, B.; NICO, M.; LOURENCO, S.conferenceObject Congenital Syphilis: A case report(2017) WU, Isabelle; RIVITTI-MACHADO, Maria Cecilia; ORLANDI, Renata; AMED FILHO, Abes Mahmed; NICO, Marcello Menta SimonsenconferenceObject Morphological alterations in labial salivary gland in patients who underwent radiotherapy(2013) BOLOGNA, S.; TESHIMA, T. H. N.; NUNES, T. B.; DURAZZO, M. D.; NICO, M. M. Simonsen; LOURENCO, S. V.conferenceObject Nail apparatus melanoma: Experience of 10 years in a single institution(2018) LEE, Desiree; ARBACHE, Samia; SANTOS, Maria Victoria Pinto Quaresma; NICO, Marcello; GABBI, TatianaconferenceObject Ross syndrome: A case report(2017) COSENZA, Fernanda Dagir; VALENTE, Neusa; FERREIRA, Paula; MENTA, MarcelloconferenceObject Primary tumors of the nail unit: A retrospective analysis of 98 patients(2017) ITO, Guilherme Kenji; ASSALIN, Adriana Rochetto; NICO, Marcello Menta Simonsen; GABBI, Tatiana Villas BoasconferenceObject Expression of claudins-1,-3,-5,-7 and-11 on the progression of squamous cell carcinoma of the lip(2012) LASCANE, N.; CARVALHO, A. d Moraes; NEVES, A. d Costa; COUTINHO-CAMILLO, C. M.; NICO, M. M. Simonsen; LOURENCO, S. V.Objective: Claudins are integral transmembrane proteins of tight junctions, critical for maintenance of cell adhesion and polarity. Altered claudin expression has been detected in carcinomas and correlates with tumour progression. Actinic cheilits is a pathologic condition that affects the lower lip, caused by chronic exposure to solar radiation; it corresponds to the early phase of squamous cell carcinoma. We investigated claudin patterns in phases of actinic cheilitis, as alterations in adhesion molecules are considered important during the progression of this process. Method: Immunohistochemistry against claudins − 1, − 3, − 5, − 7and − 11 was performed in 100 cases of actinic cheilitis/squamous cell carcinoma; results were analysed qualitatively. Results: Actinic cheilitis (low grade intraepithelial squamous cell carcinoma), and the invasive front of superficially invasive squamous cell carcinoma and in situ squamous cell carcinoma were negative for claudins − 1, − 3and − 7. Claudin − 5 was present on all epithelial layers in most cases evaluated. Claudin − 11 was present in all epithelial layers in actinic cheilitis, but negative in cases of superficially invasive and deeply invasive squamous cell carcinoma. Conclusion: Altered expression of claudins is present in AC from its incipient phase throughout the progression of the disease to invasive squamous cell carcinoma.