HERALDO POSSOLO DE SOUZA

(Fonte: Lattes)
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Lattes
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Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/02 - Laboratório de Anatomia Médico-Cirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 39
  • bookPart
    Abordagem do paciente na sala de emergência
    (2022) SOARES, Arthur de Campos; ALENCAR, Júlio César Garcia de; SOUZA, Heraldo Possolo de
  • article 0 Citação(ões) na Scopus
    Exercise Induced-Cytokines Response in Marathon Runners: Role of ACE I/D and BDKRB2+9/-9 Polymorphisms
    (2022) SIERRA, Ana Paula Renno; GALAN, Bryan Steve Martinez; SOUSA, Cesar Augustus Zocoler de; MENEZES, Duane Cardoso de; BRANQUINHO, Jessica Lais de Oliveira; NEVES, Raquel Leao; ARATA, Julia Galanakis; BITTENCOURT, Clarissa Azevedo; BARBEIRO, Hermes Vieira; SOUZA, Heraldo Possolo de; PESQUERO, Joao Bosco; CURY-BOAVENTURA, Maria Fernanda
    Renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) have a different site of interaction and modulate vascular tone and inflammatory response as well on exercise adaptation, which is modulated by exercise-induced cytokines. The aim of the study was to evaluate the role of ACE I/D and BDKRB2 +9/-9 polymorphism on exercise-induced cytokine response. Seventy-four male marathon finishers, aged 30 to 55 years, participated in this study. Plasma levels of exercise-induced cytokines were determined 24 h before, immediately after, and 24 h and 72 h after the Sao Paulo International Marathon. Plasma concentrations of MCP-1, IL-6 and FGF-21 increased after marathon in all genotypes of BDKRB2. IL-10, FSTL and BDNF increased significantly after marathon in the genotypes with the presence of the -9 allele. FSTL and BDNF concentrations were higher in the -9/-9 genotype compared to the +9/+9 genotype before (p = 0.006) and after the race (p = 0.023), respectively. Apelin, IL-15, musclin and myostatin concentrations were significantly reduced after the race only in the presence of -9 allele. Marathon increased plasma concentrations of MCP1, IL-6, BDNF and FGF-21 in all genotypes of ACE I/D polymorphism. Plasma concentrations of IL-8 and MIP-1alpha before the race (p = 0.015 and p = 0.031, respectively), of MIP-1alpha and IL-10 after the race (p = 0.033 and p = 0.047, respectively) and VEGF 72 h after the race (p = 0.018) were lower in II homozygotes compared to runners with the presence of D allele. One day after the race we also observed lower levels of MIP-1alpha in runners with II homozygotes compared to DD homozygotes (p = 0.026). Before the marathon race myostatin concentrations were higher in DD compared to II genotypes (p = 0.009). Myostatin, musclin, IL-15, IL-6 and apelin levels decreased after race in genotypes with the presence of D allele. After the race ACE activity was negatively correlated with MCP1 (r = -56, p < 0.016) and positively correlated with IL-8, IL-10 and MIP1-alpha (r = 0.72, p < 0.0007, r = 0.72, p < 0.0007, r = 0.47, p < 0.048, respectively). The runners with the -9/-9 genotype have greater response in exercise-induced cytokines related to muscle repair and cardioprotection indicating that BDKRB2 participate on exercise adaptations and runners with DD genotype have greater inflammatory response as well as ACE activity was positively correlated with inflammatory mediators. DD homozygotes also had higher myostatin levels which modulates protein homeostasis.
  • bookPart
    Sepse
    (2022) ALENCAR, Júlio César Garcia de; PESSINI, Victor Cezar de Azevedo; JORDãO, Victor Navarro; SOUZA, Heraldo Possolo de
  • bookPart
    Abordagem incial do paciente com dispneia
    (2022) BRANDãO NETO, Rodrigo Antonio; RIBEIRO, Sabrina Corrêa da Costa; SOUZA, Heraldo Possolo de
  • bookPart
    Delirium
    (2022) ALENCAR, Júlio César Garcia de; COSTA, Milena Gomes Pinheiro; NASCIMENTO, Saionara Maria Nunes; FARIA, Carine Carrijo de; SOUZA, Heraldo Possolo de
  • bookPart
    Abordagem inicial do paciente com dispneia
    (2022) RIBEIRO, Sabrina Corrêa da Costa; SOUZA, Heraldo Possolo de; BRANDãO NETO, Rodrigo Antonio
  • bookPart
    Apresentação
    (2022) VELASCO, Irineu Tadeu; BRANDãO NETO, Rodrigo Antonio; SOUZA, Heraldo Possolo de; MARINO, Lucas Oliveira; MARCHINI, Júlio Flávio Meirelles; ALENCAR, Júlio César Garcia de
  • conferenceObject
    COVID-19 and H1N1 Pneumonia: Reanalysis and Comparison of Two Cohorts
    (2022) SORICE, E.; STERNLICHT, J.; SANTOS, L. B.; BRANDAO, R.; MARINO, L.; MARCHINI, J.; ALENCAR, J.; GOMEZ, L.; SOUZA, H.
  • bookPart
    Náuseas e vômitos
    (2022) SOUZA, Heraldo Possolo de; BRANDãO NETO, Rodrigo Antonio
  • bookPart
    Plaquetopenia
    (2022) BRANDãO NETO, Rodrigo Antonio; SOUZA, Heraldo Possolo de