CARLOS FREDERICO SPARAPAN MARQUES

(Fonte: Lattes)
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Lattes
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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto Central, Hospital das Clínicas, Faculdade de Medicina

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  • article 3 Citação(ões) na Scopus
    Magnifying chromoendoscopy is a reliable method in the selection of rectal neoplasms for local excision
    (2023) KIMURA, C. M. S.; KAWAGUTI, F. S.; HORVAT, N.; NAHAS, C. S. R.; MARQUES, C. F. S.; PINTO, R. A.; REZENDE, D. T. de; SEGATELLI, V.; SAFATLE-RIBEIRO, A. V.; JUNIOR, U. R.; MALUF-FILHO, F.; NAHAS, S. C.
    Purpose Adequate staging of early rectal neoplasms is essential for organ-preserving treatments, but magnetic resonance imaging (MRI) frequently overestimates the stage of those lesions. We aimed to compare the ability of magnifying chromoendoscopy and MRI to select patients with early rectal neoplasms for local excision. Methods This retrospective study in a tertiary Western cancer center included consecutive patients evaluated by magnifying chromoendoscopy and MRI who underwent en bloc resection of nonpedunculated sessile polyps larger than 20 mm, laterally spreading tumors (LSTs) >= 20 mm, or depressed-type lesions of any size (Paris 0-IIc). Sensitivity, specificity, accuracy, and positive and negative predictive values of magnifying chromoendoscopy and MRI to determine which lesions were amenable to local excision (i.e., <= T1sm1) were calculated. Results Specificity of magnifying chromoendoscopy was 97.3% (95% CI 92.2-99.4), and accuracy was 92.7% (95% CI 86.7-96.6) for predicting invasion deeper than T1sm1 (not amenable to local excision). MRI had lower specificity (60.5%, 95% CI 43.4-76.0) and lower accuracy (58.3%, 95% CI 43.2-72.4). Magnifying chromoendoscopy incorrectly predicted invasion depth in 10.7% of the cases in which the MRI was correct, while magnifying chromoendoscopy provided a correct diagnosis in 90% of the cases in which the MRI was incorrect (p = 0.001). Overstaging occurred in 33.3% of the cases in which magnifying chromoendoscopy was incorrect and 75% of the cases in which MRI was incorrect. Conclusion Magnifying chromoendoscopy is reliable for predicting invasion depth in early rectal neoplasms and selecting patients for local excision.
  • article 3 Citação(ões) na Scopus
    Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization
    (2023) CRIVELLI, Lucia; CALANDRI, Ismael Luis; SUEMOTO, Claudia Kimie; SALINAS, Rosa Maria; VELILLA, Lina Marcela; YASSUDA, Monica Sanches; CARAMELLI, Paulo; LOPERA, Francisco; NITRINI, Ricardo; SEVLEVER, Gustavo Emilio; SOSA, Ana Luisa; ACOSTA, Daisy; BAIETTI, Ana Maria Charamelo; CUSICANQUI, Maria Isabel; CUSTODIO, Nilton; SIMONE, Sergio Dansilio De; DERIO, Carolina Delgado; DUQUE-PENAILILLO, Lissette; DURAN, Juan Carlos; JIMENEZ-VELAZQUEZ, Ivonne Z.; LEON-SALAS, Jorge Mario; BERGAMO, Yanina; CLARENS, Maria Florencia; DAMIAN, Andres; DEMEY, Ignacio; HELOU, Maria Belen; MARQUEZ, Carlos; MARTIN, Maria Eugenia; MARTIN, Maria da Graca Morais; QUERZE, Diego; SURACE, Ezequiel Ignacio; ACOSTA-EGEA, Sabrina; AGUIRRE-SALVADOR, Esteban; SOUZA, Leonardo Cruz de; CANCADO, Gustavo Henrique da Cunha Peixoto; BRUCKI, Sonia Maria Dozzi; FRIEDLAENDER, Clarisse Vasconcelos; GOMES, Karina Braga; GUTIERREZ, Myriam; RIOS, Carlos Laforcada; GALINDO, Joyce Graciela Martinez; MONTESINOS, Rosa; NUNEZ-HERRERA, Alberto; OSPINA-HENAO, Sebastian; RODRIGUEZ, Guillermina; MASSON, Victoria Ruiz; SANCHEZ, Monica; SCHENK, Christian E.; SOTO, Ligia; BARBOSA, Maira Tonidandel; TOSATTI, Jessica Abdo Goncalves; VICUNA, Yosselin; ESPELAND, Mark; HAKANSSON, Krister; KIVIPELTO, Miia; BAKER, Laura; SNYDER, Heather; CARRILLO, Maria; ALLEGRI, Ricardo Francisco
    INTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.