FREDERICO MENNUCCI DE HAIDAR JORGE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Clinically suspected neuromyelitis optica associated to anti-MOG antibodies(2015) SALLES, L. M. O. de Paula; SATO, D. K.; APOATOLOS-PEREIRA, S. L.; SIMM, R. F.; JORGE, F. M. H.; FUJIHARA, K.; CALLEGARO, D.conferenceObject Evaluation of treatment response to plasmapheresis in acute exacerbations of neuromyelitis optica(2014) LINHARES, G. E. S.; PEREIRA, S. L. A.; JORGE, F. M. H.; SIMM, R.; OLIVEIRA, L. M.; MENDES, L. S.; CALLEGARO, D.conferenceObject Cerebrospinal Fluid Aquaporin-4 Antibody Levels in Neuromyelitis Optica Attacks(2015) SATO, D. K.; CALLEGARO, D.; JORGE, F. M. H.; NAKASHIMA, I.; NISHIYAMA, S.; TAKAHASHI, T.; SIMM, R. F.; APOSTOLOS-PEREIRA, S. L.; MISU, T.; STEINMAN, L.; AOKI, M.; FUJIHARA, K.conferenceObject Rituximab treatment in antiAQP4 positive patients with a 6-month reinfusion protocol(2017) TORRETTA, P. H. B.; APOSTOLOS-PEREIRA, S. L.; PITOMBEIRA, M. S.; JORGE, F. M. H.; SATO, D. K.; CALLEGARO, D.conferenceObject Autoantibodies against MOG and aquaporin-4 identify distinct neuromyelitis optica spectrum disorders subgroups(2014) SATO, D. K.; CALLEGARO, D.; LANA-PEIXOTO, M. A.; WATERS, P. J.; TANAKA, S.; JORGE, F. M. H.; TAKAHASHI, T.; MISU, T.; APOSTOLOS-PEREIRA, S. L.; TALIM, N.; SIMM, R. F.; NAKASHIMA, I.; NOMURA, K.; AOKI, M.; FUJIHARA, K.conferenceObject Disease course in adult patients with MOG antibody-associated demyelinating disease(2017) OLIVEIRA, L. M.; SATO, D. K.; APOSTOLOS-PEREIRA, S.; SIMM, R. F.; JORGE, F. M. H.; CALLEGARO, D.conferenceObject Brainstem symptoms as first attack in NMO - Brazilian experience(2012) JORGE, F. M. H.; MELO, P.; APOSTOLOS, S.; SIMM, R.; HOBI, C.; MORAES, L.; FAZZITO, M.; SATO, D.; LANA-PEIXOTO, M.; CALLEGARO, D.- C9ORF72 repeated expansion in patients with familial amyotrophic lateral sclerosis from a Brazilian research center. A preliminary report(2015) CHADI, G.; MAXIMINO, J. R.; JORGE, F. M. H.; CALLEGARO, D.
- Beyond weakness: Characterization of pain, sensory profile and conditioned pain modulation in patients with motor neuron disease: A controlled study(2018) LOPES, L. C. G.; GALHARDONI, R.; SILVA, V.; JORGE, F. M. H.; YENG, L. T.; CALLEGARO, D.; CHADI, G.; TEIXEIRA, M. J.; ANDRADE, D. Ciampi deBackgroundMotor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non-motor symptoms in these patients have been rarely reported. MethodsThis cross-sectional study aimed to describe non-motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55.712.9years old) with MND underwent a neurological examination, pain, mood, catastrophizing and psychophysics assessments [quantitative sensory testing (QST) and conditioned pain modulation (CPM)], and were compared to sex- and age-matched healthy controls (HC). ResultsChronic pain was present in 46% of patients (VAS=5.182.0). Pain of musculoskeletal origin occurred in 40.5% and was mainly located in the head/neck (51%) and lower back (35%). Neuropathic pain was not present in this sample. Compared to HC, MND patients had a lower cold detection threshold (p<0.002), and significantly lower CPM scores (4.9 +/- 0.2% vs. 22.1 +/- 0.2%, p=0.012). QST/CPM results did not differ between MND patients with and without pain. Pain intensity was statistically correlated with anxiety, depression and catastrophism, and spasticity scores were inversely correlated with CPM (=-0.30, p=0.026). ConclusionsPain is frequently reported by patients with MNDs. Somatosensory and CPM changes exist in MNDs and may be related to the neurodegenerative nature of the disease. Further studies should investigate the most appropriate treatment strategies for these patients. SignificanceWe report a comprehensive evaluation of pain and sensory abnormalities in motor neuron disease (MND) patients. We assessed the different pain syndromes present in MND with validated tools, and described the QST and conditioned pain modulation profiles in a controlled design.
conferenceObject Brainstem symptoms as the first manifestation of neuromyelitis optica spectrum disorders(2013) JORGE, F. M. H.; SATO, D. K.; APOSTOLOS-PEREIRA, S.; SIMM, R.; ZAGO, P.; LANA-PEIXOTO, M. A.; TAKAHASHI, T.; FUJIHARA, K.; CALLEGARO, D.