MARCELLA SOARES PINCELLI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
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- Livedo Racemosa: Clinical, Laboratory, and Histopathological Findings in 33 Patients(2021) PINCELLI, Marcella Soares; ECHAVARRIA, Alejandra Maria Jimenez; CRIADO, Paulo Ricardo; MARQUES, Gabriela Franco; MORITA, Thamara Cristiane Alves Batista; VALENTE, Neusa Yuriko Sakai; CARVALHO, Joselio Freire deLivedo racemosa is a cutaneous finding characterized by a persistent, erythematous, or violaceous discoloration of the skin, in a broken, branched, discontinuous, and irregular pattern. A retrospective review of 33 cases with clinical diagnosis of livedo racemosa over the past 6 years was evaluated in the dermatology department of a tertiary care hospital. We found predominance in Caucasian women (78.8%); age ranged from 8 to 81 years, with a mean age of 36 years. Livedo racemosa was described as generalized in 12 patients (36.4%), although the main localization was on lower limbs (42%). After laboratory testing and histopathological examinations, 12 patients (36.4%) were classified with idiopathic livedo racemosa; secondary diseases were diagnosis in 21 patients (63.6%), including Sneddon's syndrome, cutaneous polyarteritis nodosa, systemic lupus erythematosus, and others. Medical history of thrombotic events was described in 8 (24.2%) patients, and also 8 (24.2%) patients had abnormal results for 2 or more thrombophilia laboratory tests. Skin biopsy showed no histological abnormalities in 11 cases (33.3%), thrombosis of dermal blood vessels in 10 (30.3%), intimal/subintimal thickening in 7 (21.2%), and vasculitis in 5 (15.2%). In conclusion, livedo racemosa is a clinical feature that might be correlated to vascular disorders, such as thrombotic and/or hypercoagulable states, autoimmune diseases, and neoplastic diseases, or it can be secondary to specific medications. It is essential to establish a correct approach in cases of livedo racemosa, which includes anamnesis, physical examination, laboratory test, histological examination, and complementary examination according to clinical findings, in order to diagnosis underlying causes.
bookPart Dermatoses agudas(2021) PINCELLI, Marcella Soares; GUIMARãES, Ana Lúcia Monteiro; NICO, Marcello Menta SimonsenbookPart Vitiligo vulvar na infância e na adolescência(2021) SANTI, Claudia Giuli; PINCELLI, Marcella SoaresbookPart Eczema, líquen simples crônico e psoríase vulvar na infância e na adolescência(2021) SANTI, Claudia Giuli; PINCELLI, Marcella SoaresbookPart Farmacodermias(2021) GUIMARãES, Ana Lúcia Monteiro; PINCELLI, Marcella Soares; NICO, Marcello Menta Simonsen