SHIRLEY VASCONCELOS KOMNINAKIS

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  • article 7 Citação(ões) na Scopus
    Re-emergence of mayaro virus and coinfection with chikungunya during an outbreak in the state of Tocantins/Brazil
    (2022) MARINHO, Robson dos Santos Souza; DURO, Rodrigo Lopes Sanz; CALDEIRA, Debora Bellini; GALINSKAS, Juliana; MOTA, Manlio Tasso Oliveira; HUNTER, James; TELES, Maria da Aparecida Rodrigues; MILAGRES, Flavio Augusto de Padua; DIAZ, Ricardo Sobhie; KAWAKUBO, Fernando Shinji; KOMNINAKIS, Shirley Vasconcelos
    Objective To perform a molecular screening to detect infections by the mayaro virus and possible coinfections with Chikungunya during an outbreak in the state of Tocantins/Brazil in 2017. Results Of a total 102 samples analyzed in this study, 6 cases were identified with simultaneous infection between mayaro and chikungunya viruses (5.88%). In these 6 samples, the mean Cycle threshold (Ct) for CHIKV was 26.87 (SD +/- 10.54) and for MAYV was 29.58 (SD +/- 6.34). The mayaro sequences generated showed 95-100% identity to other Brazilian sequences of this virus and with other MAYV isolates obtained from human and arthropods in different regions of the world. The remaining samples were detected with CHIKV monoinfection (41 cases), DENV monoinfection (50 cases) and coinfection between CHIKV/DENV (5 cases). We did not detect MAYV monoinfections.
  • article 0 Citação(ões) na Scopus
    Detection of human feces pecovirus in newly diagnosed HIV patients in Brazil
    (2022) DURO, Rodrigo Lopes Sanz; MARINHO, Robson dos Santos Souza; SANTANA, Valquiria Lima; MONTI, Elis Muriel Marques; ONIAS, Humberto; MATSUDA, Elaine Monteiro; DIAZ, Ricardo Sobhie; ISIDORO, Karina Rente; DELWART, Eric; LEAL, Elcio; KOMNINAKIS, Shirley Vasconcelos
    Circular single stranded DNA viruses (CRESS DNA) encoding a homologous replication-associated protein (REP) have been identified in most of eukaryotic groups. It is not clear yet the role in human diseases or details of the life cycle of these viruses. Recently, much interest has been raised in the evolutionary history of CRESS DNA owing to the increasing number of new sequences obtained by Next-Generation Sequencing (NGS) in distinct host species. In this study we describe two full-length CRESS DNA genomes obtained of two newly diagnosed HIV patients from Sao Paulo State, Brazil. The initial BLASTx search indicated that both sequences (named SP-FFB/2020 and SP-MJMS/2020) are highly similar (98%) to a previous CRESS DNA sequence detected in human fecal sample from Peru in 2016 and designated as pecovirus (Peruvian stool-associated circo-like virus). This study reported for the first time the Human feces pecovirus in the feces of two newly diagnosed HIV patients in Brazil. Our comparative analysis showed that although pecoviruses in South America share an identical genome structure they diverge and form distinct clades. Thus, we suggest the circulation of different species of pecoviruses in Latin America. Nevertheless, further studies must be done to examine the pathogenicity of this virus.