MIRIAN NACAGAMI SOTTO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Patologia, Faculdade de Medicina - Docente
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Necrotisans erythema nodosum leprosum with systemic manifestations(2018) ISHIY, Patricia; TRINDADE, Maria Angela; AVANCINI, Joao; PAZZINI, Renato; JORGE, Lecticia; SOTTO, MirianconferenceObject NY-ESO-1 Expression Is Associated with Melanoma Thickness, but Not Mortality(2013) GIAVINA-BIANCHI, Mara; SOTTO, Miriam Nacagamo; KANASHIRO, Luciane; SIMPSON, Andrew J.; GIAVINA-BIANCHI, Pedro; KALIL, Jorge; FESTA, CyroRATIONALE: It is important to study the expression of cancer-testis antigens such as NY-ESO-1, because they can help not only in diagnosis, but can be a very interesting target for immunotherapy against cancer. The aim of this study was to correlate the expression of cancer-testis antigen NY-ESO-1 with morbidity and mortality of cutaneous melanoma. METHODS: This was a retrospective cohort with 471 patients. They were separated in three groups: 1-Thinmelanoma (in situ or thickness < 1.1mm); 2- Intermediate (from 1.1 to 4.0mm); and 3- Thick tumors (> 4.0mm). We randomly sortedout 31,28and31casesfromgroups1,2and3,respectively, totalizing 90 melanoma cases. The patients’ charts were reviewed, and the clinicopathological parameters analyzed. The tumor specimens were also reviewed and subsequently subjected to immunohistochemical examination to study the expression of tumor protein NY-ESO-1. RESULTS: Therewas no statistical difference between groups NY-ESO-1 positive (25% of cases) and negative (75% of cases) with respect to gender, race, skin type, age, tumor location, pre-existing lesion, histological type, Breslow index, ulceration, sentinel lymph node, metastases development and survival rates. Melanomas NY-ESO-1 positivewere on average thicker than the negative ones (p 50.026). CONCLUSIONS: Immunohistochemistry with antibodies NY-ESO-1 was positive in 25% of melanom’s biopsy specimens. The expression of NY-ESO-1 was associated with tumor thickness, but not mortality from melanoma.conferenceObject Claudins expression profile in squamous cell carcinoma of epidermodysplasia verruciformis(2014) TANABE, Claudia Kwei Fong Dai; HALPERN, Ilana; SILVA, Lana Luiza da Cruz; MATTOS, Mayra Servilha Grion; SOTTO, Mirian N.; OLIVEIRA, Walmar Roncalli PereiraconferenceObject Comparative analysis of the in situ interleukin 23/T-helper 17 lymphocyte axis cytokine profile in IgA pemphigus, subcorneal pustular dermatosis, and pustular psoriasis(2014) SIGNORELLI, Thais Helena Dias; MARUTA, Celina Wakisaka; SANTI, Claudia Giuli; SOTTO, Mirian Nacagami; DIAS, Natasha Favoretto; ROMITI, Ricardo; AOKI, ValeriaconferenceObject CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) EXPRESSION IN MICE PROMOTES CONTROL OF EXPERIMENTAL CUTANEOUS LEISHMANIASIS(2021) OZAKI, C. Y.; DANTAS, F. E.; SANTANA, K. G.; TAFURI, W.; SOTTO, M. N.; GOTO, H.; CAZITA, P. M.conferenceObject Histopathological Aspects of Acute-Form Paracoccidioidomycosis in IL-12BR1 Deficient Patients(2014) VASCONCELOS, D. Moraes; CAMPEAS, A. E.; FERRAO, M. S.; YU, C. L.; PAGLIARI, C.; BRASIL, R. A.; SOTTO, M. N.; DUARTE, M. I. S.conferenceObject NY-ESO-1 expression is associated with primary cutaneous melanoma thickness(2014) BIANCHI, Mara Giavina; FESTA NETO, Cyro; DUNCAN, Lyn; SOTTO, MiriamconferenceObject Nodular primary cutaneous melanoma is associated with PD-L1 expression(2020) BIANCHI, Mara Giavina; SOTTO, Mirian; GIAVINA-BIANCHI, Pedro; NETO, Cyro Festa; DUNCAN, Lyn M.; KALIL, JorgeconferenceObject Increased vascular endothelial growth factor expression in erythrodermic pemphigus foliaceus patients(2016) MIYAMOTO, Denise; OTANI, Camila Sayuri Vicentini; FUKUMORI, Ligia Maria Ichimura; PEREIRA, Naiura Vieira; SOTTO, Mirian Nacagami; MARUTA, Celina Wakisaka; SANTI, Claudia Giuli; REBEIS, Marina Mattos; AOKI, ValeriaconferenceObject Analysis of the ocular surface of patients with atopic dermatitis revealed decreased expression of filaggrin, a key element of the epithelial barrier.(2017) CALLOU, Thais Pinheiro; SOTTO, Mirian; PEREIRA, Naiura; AOKI, Valeria; SANTO, Ruth