JOSE EDUARDO KRIEGER
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
- Altered sleep architecture in diabetes and prediabetes: findings from the Baependi Heart Study(2024) CHEN, Daniel M.; TAPOROSKI, Tamara P.; ALEXANDRIA, Shaina J.; AABY, David A.; BEIJAMINI, Felipe; KRIEGER, Jose E.; SCHANTZ, Malcolm von; PEREIRA, Alexandre C.; KNUTSON, Kristen L.Study objectives: People with diabetes and prediabetes are more likely to have sleep-disordered breathing (SDB), but few studies examined sleep architecture in people with diabetes or prediabetes in the absence of moderate-severe SDB, which was the aim of our cross-sectional study. Methods: This cross-sectional sample is from the Baependi Heart Study, a family-based cohort of adults in Brazil. About 1074 participants underwent at-home polysomnography (PSG). Diabetes was defined as fasting glucose >125 mg/dL or HbA1c > 6.4 mmol/mol or taking diabetic medication, and prediabetes was defined as HbA1c >= 5.7 & <6.5 mmol/mol or fasting glucose >= 100 & <= 125 mg/dl. We excluded participants with an apnea-hypopnea index (AHI) >= 30 in primary analyses and >= 15 in secondary analysis. We compared sleep stages among the 3 diabetes groups (prediabetes, diabetes, neither). Results: Compared to those without diabetes, we found shorter REM duration for participants with diabetes (-6.7 min, 95%CI -13.2, -0.1) and prediabetes (-5.9 min, 95%CI -10.5, -1.3), even after adjusting for age, gender, BMI, and AHI. Diabetes was also associated with lower total sleep time (-13.7 min, 95%CI -26.8, -0.6), longer slow-wave sleep (N3) duration (+7.6 min, 95%CI 0.6, 14.6) and higher N3 percentage (+2.4%, 95%CI 0.6, 4.2), compared to those without diabetes. Results were similar when restricting to AHI < 15. Conclusions: People with diabetes and prediabetes had less REM sleep than people without either condition. People with diabetes also had more N3 sleep. These results suggest that diabetes and prediabetes are associated with differences in sleep architecture, even in the absence of moderate-severe sleep apnea.
- Enhancing Arrhythmogenic Right Ventricular Cardiomyopathy Detection and Risk Stratification: Insights from Advanced Echocardiographic Techniques(2024) OLIVETTI, Natalia; SACILOTTO, Luciana; MOLETA, Danilo Bora; FRANCA, Lucas Arraes de; CAPELINE, Lorena Squassante; WULKAN, Fanny; WU, Tan Chen; PESSENTE, Gabriele D'Arezzo; CARVALHO, Mariana Lombardi Peres de; HACHUL, Denise Tessariol; PEREIRA, Alexandre da Costa; KRIEGER, Jose E.; SCANAVACCA, Mauricio Ibrahim; VIEIRA, Marcelo Luiz Campos; DARRIEUX, FranciscoIntroduction: The echocardiographic diagnosis criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly specific but sensitivity is low, especially in the early stages of the disease. The role of echocardiographic strain in ARVC has not been fully elucidated, although prior studies suggest that it can improve the detection of subtle functional abnormalities. The purposes of the study were to determine whether these advanced measures of right ventricular (RV) dysfunction on echocardiogram, including RV strain, increase diagnostic value for ARVC disease detection and to evaluate the association of echocardiographic parameters with arrhythmic outcomes. Methods: The study included 28 patients from the Heart Institute of S & atilde;o Paulo ARVC cohort with a definite diagnosis of ARVC established according to the 2010 Task Force Criteria. All patients were submitted to ECHO's advanced techniques including RV strain, and the parameters were compared to prior conventional visual ECHO and CMR. Results: In total, 28 patients were enrolled in order to perform ECHO's advanced techniques. A total of 2/28 (7%) patients died due to a cardiovascular cause, 2/28 (7%) underwent heart transplantation, and 14/28 (50%) patients developed sustained ventricular arrhythmic events. Among ECHO's parameters, RV dilatation, measured by RVDd (p = 0.018) and RVOT PSAX (p = 0.044), was significantly associated with arrhythmic outcomes. RV free wall longitudinal strain < 14.35% in absolute value was associated with arrhythmic outcomes (p = 0.033). Conclusion: Our data suggest that ECHO's advanced techniques improve ARVC detection and that abnormal RV strain can be associated with arrhythmic risk stratification. Further studies are necessary to better demonstrate these findings and contribute to risk stratification in ARVC, in addition to other well-known risk markers.
- Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas(2024) HUGHES, Odessica; BENTLEY, Amy R.; BREEZE, Charles E.; AGUET, Francois; XU, Xiaoguang; NADKARNI, Girish; SUN, Quan; LIN, Bridget M.; GILLILAND, Thomas; MEYER, Mariah C.; DU, Jiawen; RAFFIELD, Laura M.; KRAMER, Holly; MORTON, Robert W.; GOUVEIA, Mateus H.; ATKINSON, Elizabeth G.; VALLADARES-SALGADO, Adan; WACHER-RODARTE, Niels; DUEKER, Nicole D.; GUO, Xiuqing; HAI, Yang; ADEYEMO, Adebowale; BEST, Lyle G.; CAI, Jianwen; CHEN, Guanjie; CHONG, Michael; DOUMATEY, Ayo; EALES, James; GOODARZI, Mark O.; IPP, Eli; IRVIN, Marguerite Ryan; JIANG, Minzhi; JONES, Alana C.; KOOPERBERG, Charles; KRIEGER, Jose E.; LANGE, Ethan M.; LANKTREE, Matthew B.; LASH, James P.; LOTUFO, Paulo A.; LOOS, Ruth J. F.; MY, Vy Thi Ha; PERALTA-ROMERO, Jesus; QI, Lihong; RAFFEL, Leslie J.; RICH, Stephen S.; RODRIQUEZ, Erik J.; TARAZONA-SANTOS, Eduardo; TAYLOR, Kent D.; UMANS, Jason G.; WEN, Jia; YOUNG, Bessie A.; YU, Zhi; ZHANG, Ying; CHEN, Yii-Der Ida; RUNDEK, Tanja; ROTTER, Jerome I.; CRUZ, Miguel; FORNAGE, Myriam; LIMA-COSTA, Maria Fernanda; PEREIRA, Alexandre C.; PARE, Guillaume; NATARAJAN, Pradeep; COLE, Shelley A.; CARSON, April P.; LANGE, Leslie A.; LI, Yun; PEREZ-STABLE, Eliseo J.; DO, Ron; CHARCHAR, Fadi J.; TOMASZEWSK, Maciej; MYCHALECKYJ, Josyf C.; ROTIM, Charles; MORRIS, Andrew P.; FRANCESCHIN, NoraChronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under -represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta -analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p < 5 x 10(-8)), of which two have not been previously reported in any ancestry group. We integrated fine -mapped loci with epigenomic and transcriptomic resources to highlight potential effector genes relevant to kidney physiology and disease, and reveal key regulatory elements and pathways involved in renal function and development. We demonstrate the varying but increased predictive power offered by a multi -ancestry polygenic score for eGFR and highlight the importance of population diversity in GWASs and multi-omics resources to enhance opportunities for clinical translation for all.