CAMILLE PINTO FIGUEIREDO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
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conferenceObject Performance of FRAX (R) Brazil and NOGG Methodology with and Without Bone Mineral Density upon Predicting Fractures on a Community-Dwelling Elderly Population with High Incidence of Osteoporotic Fractures: The Sao Paulo Ageing and Health (SPAH) Study(2022) FREITAS, Thiago Q.; OLALLA, Leonardo F. G.; TAKAYAMA, Liliam; CAPARBO, Valeria; FIGUEIREDO, Camille; MACHADO, Luana; DOMICIANO, Diogo; PEREIRA, RosaconferenceObject Bone Erosions and Osteophytes in Premenopausal Women with Long-standing Rheumatoid Arthritis: Association with Systemic Bone Involvement Using HR-pQCT(2021) PEREZ, Mariana; FIGUEIREDO, Camille; SALES, Lucas; MEDEIROS-RIBEIRO, Ana; TAKAYAMA, Liliam; DOMICIANO, Diogo; BONFIGLIOLI, Karina; CAPARBO, Valeria; PEREIRA, RosaconferenceObject Effect of Sarcopenia, Subcutaneous Adipose Tissue and Abdominal Visceral Fat on Mortality Risk of Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study(2016) SANTANA, Felipe M.; GONCALVES, Michel A.; DOMICIANO, Diogo S.; MACHADO, Luana G.; LOPES, Jaqueline B.; FIGUEIREDO, Camille P.; CAPARBO, Valeria; TAKAYAMA, Liliam; PEREIRA, Rosa M. R.conferenceObject Effects of DMARD Tapering on Treatment Costs and Work Productivity in Rheumatoid Arthritis Patients- an Analysis from the Prospective Randomized Controlled Retro- Study(2016) HAGEN, Melanie; FIGUEIREDO, Camille P.; COBRA, Jayme Fogagnolo; HASCHKA, Judith; REISER, Michaela; ENGLBRECHT, Matthias; HUEBER, Axel J.; MANGER, Bernhard; KLEYER, Arnd; FINZEL, Stephanie; TONY, Hans-Peter; KLEINERT, Stefan; WENDLER, Joerg; SCHUCH, Florian; RONNEBERGER, Monika; FEUCHTENBERGER, Martin; FLECK, Martin; MANGER, Karin; OCHS, Wolfgang; SCHMITT-HAENDLE, Matthias; LORENZ, H. -M.; NUSSLEIN, H. G.; ALTEN, R.; HENES, Joerg C.; KRUGER, Klaus; SCHETT, Georg; RECH, Juergen- Association of Bone Erosions and Osteophytes With Systemic Bone Involvement on High-Resolution Peripheral Quantitative Computed Tomography in Premenopausal Women With Longstanding Rheumatoid Arthritis(2022) PEREZ, Mariana O.; FIGUEIREDO, Camille P.; SALES, Lucas P.; MEDEIROS-RIBEIRO, Ana Cristina; TAKAYAMA, Liliam; DOMICIANO, Diogo S.; BONFIGLIOLI, Karina; CAPARBO, Valeria F.; PEREIRA, Rosa M. R.Objective To evaluate premenopausal women with longstanding rheumatoid arthritis (RA) for potential associations between parameters of localized bone involvement and parameters of systemic bone involvement in the affected joints. Methods Eighty consecutively evaluated premenopausal women with RA were included in the study, along with 160 healthy female control subjects who were matched to the patients by age and body mass index. Volumetric bone mineral density (vBMD), bone microarchitecture, and finite elements of biomechanical bone strength (bone stiffness and estimated failure load) at the distal radius and distal tibia were analyzed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with RA compared to healthy controls. In addition, in patients with RA, localized bone involvement in the metacarpophalangeal and proximal interphalangeal joints was analyzed by HR-pQCT, to identify bone erosions and osteophytes. Results Among the 80 premenopausal women with longstanding RA, the mean +/- SD age was 39.4 +/- 6.7 years and mean +/- SD disease duration was 9.8 +/- 5.3 years. Trabecular and cortical bone parameters and bone strength at the distal radius and distal tibia were all impaired in patients with RA compared to healthy controls (each P < 0.05). In total, 75% of RA patients had evidence of bone erosions, and 41.3% of RA patients had detectable osteophytes on HR-pQCT. RA patients with bone erosions, as compared to RA patients without bone erosions, had lower cortical vBMD (at the distal radius, mean +/- SD 980 +/- 72 mg HA/cm(3) versus 1,021 +/- 47 mg HA/cm(3) [P = 0.03]; at the distal tibia, 979 +/- 47 mg HA/cm(3) versus 1,003 +/- 34 mg HA/cm(3) [P = 0.04]) and higher cortical bone porosity (at the distal radius, mean +/- SD 2.8 +/- 2.5% versus 1.8 +/- 1.6% [P = 0.04]; at the distal tibia, 3.7 +/- 1.6% versus 2.7 +/- 1.6% [P = 0.01]). In patients with RA, osteophyte volume at the distal radius was positively correlated with trabecular vBMD (r = 0.392, P = 0.02), trabecular number (r = 0.381, P = 0.03), and trabecular stiffness (r = 0.411, P = 0.02), and negatively correlated with trabecular separation (r = -0.364, P = 0.04), as determined by Pearson's or Spearman's correlation test. Conclusion The findings show that premenopausal women with longstanding RA have systemic bone fragility at peripheral joint sites. Moreover, the presence of bone erosions is mainly associated with cortical bone fragility at the distal radius and tibia, and presence of osteophytes is associated with repair of trabecular bone at the distal radius.
conferenceObject Cortical Bone Erosion in the 2nd Metacarpal Bone Head: Association with Its Bone Mineral Density by HR-pQCT in Rheumatoid Arthritis Patients(2019) FIGUEIREDO, Camille; PEREZ, Mariana; RIBEIRO, Ana Cristina de Medeiros; CAPARBO, Valeria; PEREIRA, Rosa- Quantification and Impact of Secondary Osteoarthritis in Patients With Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis(2016) FIGUEIREDO, Camille P.; SIMON, David; ENGLBRECHT, Matthias; HASCHKA, Judith; KLEYER, Arnd; BAYAT, Sara; HUEBER, Axel; PEREIRA, Rosa M. R.; RECH, Juergen; SCHETT, GeorgObjective. To search for evidence of secondary osteoarthritis (OA) in patients with rheumatoid arthritis (RA) in a cross-sectional and longitudinal setting, and to relate osteophyte formation to functional outcome. Methods. Anti-citrullinated protein antibody (ACPA)-positive RA patients underwent high-resolution peripheral quantitative computed tomography of the hand. Cross-sectional and longitudinal measurements were performed. The number and size (volume) of osteophytes as well as bone erosions were documented. The relationship of osteophytes to bone erosions and to demographic and disease-specific data was evaluated by multiple logistic regression models. Results. A total of 202 ACPA-positive RA patients were enrolled in the cross-sectional part of the study, and a total of 77 ACPA-positive RA patients were enrolled in the longitudinal analysis (interval of 1.5 years between baseline and follow-up assessment). The meanSD number of osteophytes per patient was 1.3 +/- 2.3, and the mean +/- SD osteophyte volume per patient was 2.6 +/- 4.9 mm(3). The total number of erosions was significantly correlated with the total number of osteophytes (P<0.001), and the total volume of erosions was significantly correlated with the total volume of osteophytes (P<0.001). Moreover, the number of osteophytes was related to age (P<0.001) and disease duration (P=0.001), while the volume of osteophytes was related to age (P=0.001), disease duration (P<0.001), and function as measured by the Health Assessment Questionnaire (P=0.013). Multivariate regression analyses showed an independent association between osteophytes and erosions. In the longitudinal analysis, the mean number (P=0.033) and volume (P<0.001) of osteophytes increased significantly in RA patients during their disease course. Conclusion. Age, disease duration, and bone erosions are associated with osteophytes, indicating development of secondary OA in patients with RA.
conferenceObject Risk Factors for Low Muscle MASS in Community-Dwelling Older Women: A Population-Based Prospective Cohort Study in Brazil. the Sao Paulo Ageing & Health Study(2017) MACHADO, Ketty; DOMICIANO, Diogo S.; MACHADO, Luana G.; LOPES, Jaqueline B.; FIGUEIREDO, Camille P.; CAPARBO, Valeria F.; TAKAYAMA, Liliam; MENEZES, Paulo; PEREIRA, Rosa M. R.conferenceObject Bone Mineral Density of Radius 1/3 Led to a Better Fracture Prediction When Combined with Spine but Not Hip BMD: Results from the Sao Paulo Ageing & Health (SPAH) Study(2022) DOMICIANO, Diogo; MACHADO, Luana; CAPARBO, Valeria; CIDON, Carolina Teixeira; GORAYEB, Thais Helena Bonini; SILVA, Maria Aurora Gomes da; OLIVEIRA, Ricardo Manoel de; FIGUEIREDO, Camille; PEREIRA, RosaconferenceObject Visceral Fat Measured By Dual-Energy X-Ray Absorptiometry Is Associated with Increased Risk of Non-Spine Fractures in Nonobese Elderly Women: a Population-Based Prospective Cohort Analysis from the Sao Paulo Ageing & Health (SPAH) Study(2014) MACHADO, Luana G.; DOMICIANO, Diogo S.; FIGUEIREDO, Camille P.; LOPES, Jaqueline B.; CAPARBO, Valeria; TAKAYAMA, Liliam; OLIVEIRA, Ricardo M.; PEREIRA, Rosa M. R.