NELSON DA CRUZ GOUVEIA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Medicina Preventiva, Faculdade de Medicina - Docente
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/39 - Laboratório de Processamento de Dados Biomédicos, Hospital das Clínicas, Faculdade de Medicina - Líder
5 resultados
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- Effects of Particulate Matter and Its Chemical Constituents on Elderly Hospital Admissions Due to Circulatory and Respiratory Diseases(2016) FERREIRA, Tatiane Morais; FORTI, Maria Cristina; FREITAS, Clarice Umbelino de; NASCIMENTO, Felipe Parra; JUNGER, Washington Leite; GOUVEIA, NelsonVarious fractions of particulate matter have been associated with increased mortality and morbidity. The purpose of our study is to analyze the associations between concentrations of PM2.5, PM2.5-10, PM10 and their chemical constituents (soluble ions) with hospital admissions due to circulatory and respiratory diseases among the elderly in a medium-sized city in Brazil. A time series study was conducted using Poisson regression with generalized additive models adjusted for confounders. Statistically significant associations were identified between PM10 and PM2.5-10 and respiratory diseases. Risks of hospitalization increased by 23.5% (95% CI: 13.5; 34.3) and 12.8% (95% CI: 6.0; 20.0) per 10 mu g/m(3) of PM2.5-10 and PM10, respectively. PM2.5 exhibited a significant association with circulatory system diseases, with the risk of hospitalization increasing by 19.6% (95% CI: 6.4; 34.6) per 10 mu g/m(3). Regarding the chemical species; SO42-, NO3-, NH4+ and K+ exhibited specific patterns of risk, relative to the investigated outcomes. Overall, SO42- in PM2.5-10 and K+ in PM2.5 were associated with increased risk of hospital admissions due to both types of diseases. The results agree with evidence indicating that the risks for different health outcomes vary in relation to the fractions and chemical composition of PM10. Thus, PM10 speciation studies may contribute to the establishment of more selective pollution control policies.
- Potential oral exposure to low-dose chromium and stomach cancer mortality in the population in the interior of Sao Paulo State, Brazil(2021) OLIVEIRA, Fabio Luiz Vieira de; KUNO, Rubia; NASCIMENTO, Felipe Parra do; GOUVEIA, NelsonTotal chromium concentrations from 0.45 to 110 mu g/L have been detected in the Bauru Water Table in the Sao Paulo State, Brazil, sometimes exceeding the quality threshold adopted by Brazilian legislation, which is 50 mu g/L. According to the Sao Paulo State Environmental Company (CETESB), part of the chromium consists of the hexavalent form [Cr(VI)], which presents controversial evidence as to carcinogenicity by the oral route. This article aims to evaluate the effect of exposure to low-dose Cr(VI) on gastric cancer mortality in the population 15 to 75 years and older who consumed water from the Bauru Water Table from 2004 to 2015. An ecological study was performed in 326 municipalities situated in the Western Sao Paulo High Plain and that used water from the Bauru Water Table. The associations were estimated via linear regression, using indicators of exposure to chromium (proxy) and standardized mortality ratio (SMR) for gastric neoplasms as the response variable. The Municipal Human Development Index (MHDI) was used to control for possible socioeconomic differences in the target population. The estimated SMR for gastric cancer corresponded to 79% of the expected deaths, and the risk was lower in municipalities that have water treated by the Sao Paulo State Basic Sanitation Company (SABESP), with special attention to the female population (beta = -0.146; 95%CI: -0.270; -0.021; p = 0.022). Although the research data are limited, 77 (23.6%) of the municipalities evaluated reveal an increase in the risk of gastric cancer. Among these, nearly 70% are supplied by water tables associated with river basins with geochemical Cr(VI) anomalies.
- Individual and contextual socioeconomic status as effect modifier in the air pollution-birth outcome association(2022) NASCIMENTO, Felipe Parra do; ALMEIDA, Marcia Furquim de; GOUVEIA, NelsonBackground: Several studies have examined whether air pollution is associated with adverse births outcomes, but it is not clear if socioeconomic status (SES) modifies this relationship. Objectives: We investigated if maternal education and area-level socioeconomic status modified the relationship between ozone, nitrogen dioxide and particulate matter with aerodynamic diameter <10 mu m (PM10) on preterm births (PTB; gestational age <37 weeks) and term low birth weight (TLBW; weight < 2500 g on term deliveries). Methods: Analyses were based on almost 1 million singleton live births in Sao Paulo municipality between 2011 and 2016. The final sample included 979,306 births for PTB analysis and 888,133 for TLBW analysis. Exposure to PM10, NO2 and O-3 were based on date of birth and estimated for the entire gestation and for each trimester. Multilevel logistic regression models were conducted to examine the effect of air pollutants on both adverse birth outcomes and whether it was modified by individual and area-level SES. Results: In fully adjusted models, over the entire pregnancy, a 10 mu g/m(3) increase in O-3 and PM10 was associated with increased chance of PTB (odds ratio; OR = 1.14 CI 1.13, 1.16 and 1.08 CI = 1.02, 1.15 respectively) and PM10 with TLBW (OR = 1.08 CI 1.03, 1.14). Associations were modified by maternal educational and area-level SES for both outcomes. Mothers of lower education had an additional chance of PTB and TLBW due to PM10 exposure (OR = 1.04 CI 1.04, 1.05 and 1.10 CI 1.08, 1.14 respectively), while mothers living in low SES areas have an additional chance for TLBW (OR = 1.05 CI 1.03, 1.06). Similar modification effects were found for O-3 exposure. Trimester specific associations were weaker but followed a similar pattern. Conclusion: Socioeconomic status modifies the effect of air pollution on adverse birth outcomes. Results indicate that mothers with lower SES may be more susceptible to air pollution effects.
- Organochlorine pesticides levels and associated factors in a group of blood donors in Sao Paulo, Brazil(2017) NASCIMENTO, Felipe Parra do; KUNO, Rbia; LEMES, Vera Regina Rossi; KUSSUMI, Tereza Atsuko; NAKANO, Viviane Emi; ROCHA, Sonia Bio; OLIVEIRA, Maria Celeste Cardeal de; KIMURA, Iracema de Albuquerque; GOUVEIA, NelsonThe use of organochlorine pesticides (OCPs) is a worldwide public health concern given that high levels of these compounds in humans and animals can lead to serious health problems. This study aimed to evaluate the levels of 15 organochlorine pesticides in the serum of 547 blood donors in the Sao Paulo metropolitan region (SPMR) in 2009 and to investigate factors associated with higher levels of these compounds. The OCPs were determined by gas chromatography with micro electron capture detection. Multiple ordinal logistic regression models were employed to determine the factors associated with higher levels. Only beta-HCH and p,p'-DDE had a significant number of samples above the limit of quantification. Factors associated with higher levels of beta-HCH were age within 26 to 35 years (OR = 3.1 [1.05-9.09]), age within 36 to 45 years (OR = 18.27 [6.89-48.91]), and female gender (OR = 0.44 [0.24-0.82] for men). p, p'-DDE levels were associated with age within 26 to 35 years (OR = 2.65 [1.20-3.45]), age within 36 to 45 years (OR = 4.59 [2.64-7.92]), female gender (OR = 0.86 [0.43-0.94] for men), and previous work with pesticides (OR = 2.88 [1.22-6.84]). Lower levels of p, p'-DDE were associated with an income of 3 to 5 minimum wages (OR = 0.38 [0.19-0.75]) and with intake of foods from animal origin up to twice a week (OR = 0.15 [0.03-0.72]) and more than twice a week (OR = 0.10 [0.02-0.47]). The results of this study indicate that the study group was not exposed to high levels of OCPs.
- Prevalence and factors associated with respiratory diseases and diarrhea in recyclable material cooperative workers in the city of Sao Paulo, Brazil: a cross-sectional study, 2013(2020) SOUZA, Gisele Ferreira de; MUTO, Elizabeti Yuriko; NASCIMENTO, Felipe Parra; GOUVEIA, NelsonObjective: to analyze the prevalence of respiratory diseases and diarrhea among recyclable material cooperative workers in Sao Paulo City, Brazil, and associated factors. Methods: this was a cross-sectional study conducted in three cooperatives, with data collected through structured interviews and measurement of enviromnental fungal concentration; Poisson regression was used to estimate prevalence ratios (PR). Results: 156 individuals were interviewed; the highest asthma, chronic obstructive pulmonary disease (COPD), and diarrhea prevalence rates occurred in cooperatives with higher total fungal concentration; highest adjusted prevalence of asthma was found in Cooperative A (PR=8.44 - 95%CI 1.09;65.37), and highest adjusted prevalence of diarrhea was found in Cooperative C (PR=2.09 - 95%CI 1.11;3.94), compared to Cooperative B; the highest COPD prevalence was found in smokers and former smokers (PR=8.66 - 95% CI 2.84;26.35). Conclusion: fungal control measures must be adopted for disease prevention in recyclable material cooperatives.