CLAUDIO BOVOLENTA MURTA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
14 resultados
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- Correlation of a microRNA expression profile and the prognosis of penile cancer: A prospective study using microarray data analysis(2018) FURUYA, Tatiane K.; MURTA, Claudio B.; PONTES JR., Jose; UNO, Miyuki; CARRASCO, Alexis; SICHERO, Laura C.; VILLA, Luisa L.; COELHO, Rafael F.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio D.; LEITE, Katia R.; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William C.
- Percutaneous nephrolithotomy in patients with spinal cord injury: should all these patients be automatically assigned a Guy's stone score of 4?(2021) TORRICELLI, Fabio C. M.; VICENTINI, Fabio C.; ZANETTI, Lucas; PERRELLA, Rodrigo; MARCHINI, Giovanni S.; DANILOVIC, Alexandre; BATAGELLO, Carlos A.; MURTA, Claudio B.; CLARO, Joaquim F. A.; SROUGI, Miguel; NAHAS, William C.; MAZZUCCHI, EduardoPurpose To assess the complication and stone-free rates of PCNL in patients with spinal cord injury (SCI) and to evaluate whether this population should be assigned a Guy's stone score (GSS) of 4. Methods A case-control study was conducted, and electronic charts were reviewed to search for patients with SCI, bladder dysfunction, and kidney stones who had undergone PCNL. Control cases were randomly selected from among patients with complete staghorn calculus (GSS = 4). Results One hundred and seventeen patients were included. Patients with SCI had a significant shorter operative time (119 vs. 141 min;p = 0.018). There were no significant differences between the groups in terms of the patients' position, number of renal tracts, bleeding or transfusion rate; however, there was a significantly higher complication rate (23.1% vs. 7.8%;p = 0.009) and a longer hospital stay (5.8 vs. 3.1 days;p = 0.002) among patients with SCI. With regards to the stone-free rate in patients with different grades of GSS patients with SCI who had a GSS of 1 had a stone-free rate of 85.7%, while those with a GSS of 2, 3, or 4 had 50%, 50%, and 31.5%, respectively (p = 0.024). Only patients with a GSS of 4 in the SCI group had outcomes that were similar to those of control patients (31.5% vs. 31.6%). Conclusion Patients with SCI should not be automatically assigned GSS 4. Stone-free rate is related to stone burden in these patients, although they do show a higher complication rate and a longer hospital stay than non-neurological patients.
conferenceObject CORRELATION BETWEEN MICRORNAS AND MRNA EXPRESSION PROFILES WITH THE PROGNOSIS OF CLINICALLY LOCALIZED PENILE CANCER(2019) MURTA, Claudio; PONTES JR., Jose; FURUYA, Tatiane; UNO, Miyuki; CARRASCO, Alexis; COELHO, Rafael; GUGLIELMETTI, Giuliano; CORDEIRO, Mauricio; FARAJ, Sheila; LEITE, Katia; SICHERO, Laura; VILLA, Luisa; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, WilliamconferenceObject IS SUPINE PERCUTANEOUS NEPHROLITHOTOMY FOR COMPLEX STONES WORSE THAN PRONE? A MULTICENTER RANDOMIZED CONTROLLED TRIAL.(2021) PERRELLA, Rodrigo; VICENTINI, Fabio; PARO, Eliane; MARCHINI, Giovani; TORRICELLI, Fabio; DANILOVIC, Alexandre; BATAGELLO, Carlos; MOTA, Priscila Kuriki; BELTRAME, Daniel; COHEN, David; MURTA, Claudio; CLARO, Joaquim; NAHAS, William; SROUGI, Miguel; MAZZUCCHI, Eduardo- Effectiveness of the Moreau strain of Bacillus Calmette-Guerin (BCG) for nonmuscle invasive bladder cancer.(2017) CHADE, Daher Cezar; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; BASTOS, Diogo Assed; DZIK, Carlos; SROUGI, Miguel; NAHAS, William Carlos
conferenceObject A PROSPECTIVE ANALYSIS OF TESTOSTERONE (T) RECOVERY PROFILES AFTER NEOADJUVANT MAXIMAL ANDROGEN BLOCKADE IN HIGH-RISK LOCALIZED PROSTATE CANCER(2021) PEDRENHO NETO, Rubens; NASCIMENTO, Bruno C. G.; BASTOS, Diogo Assed; BESSA JUNIOR, Jose de; ILARIO, Eder Nisi; MURTA, Claudio Bovolenta; CORDEIRO, Mauricio Dener; COELHO, Rafael Ferreira; MULHALL, John P.; SROUGI, Miguel; NAHAS, William CarlosconferenceObject COMPLETE SUPINE PERCUTANEOUS NEPHROLITHOTOMY - OUTCOMES OF A PROSPECTIVE SERIES OF A SINGLE SURGEON(2012) VICENTINI, Fabio Carvalho; HISANO, Marcelo; MAZZUCCHI, Eduardo; CLARO, Joaquim Almeida; MURTA, Claudio Bovolenta; SROUGI, MiguelOBJECTIVE: To describe our technique and results. METHODS: A total of 117 patients (120 renal units) were evaluated in a prospective manner. One surgeon operated all the cases. All patients had a CT scan pre-operatively and the stones were classified according the Guy’s score. We performed complete supine PCNL (csPCNL) with no rolled towel under the flank and no change of position. The ipsilateral arm was hung over the thorax and the patients were draped only once. A 6Fr ureteral catheter was placed without lithotomy position. The puncture was done always by the surgeon in the selected calix under fluoroscopic vision. The tract was dilated with a double shot technique and a 30Fr Amplatz sheath was placed. A 16Fr nephrostomy tube was inserted in cases of bleeding or residual stones. A ureteral catheter or a double J was always left. A CT scan was done in the first POD in all cases. Success was defined as the presence of ≤ 4 mm fragments at the end of follow up. RESULTS: The operative time ranged between 20 and 240 minutes (mean 105.5±50.8 min). The immediate success rate was 72.5% and the final rate was 90.4% after an average of 1.08 PCNL and 0.17 auxiliary procedures. Patients were left tubeless in 38.3% of the cases. The complication rate was 15.8% (11.6% of Clavien 1 or 2 and 4.2% of Clavien 3 or 4). The transfusion rate was 4.2%. No colon injuries or deaths occurred. CONCLUSIONS: The csPCNL is a very safe and effective procedure.- Supine versus Prone Percutaneous Nephrolithotomy for Complex Stones: A Multicenter Randomized Controlled Trial(2022) PERRELLA, Rodrigo; VICENTINI, Fabio C.; PARO, Eliane D.; TORRICELLI, Fabio C. M.; MARCHINI, Giovani S.; DANILOVIC, Alexandre; BATAGELLO, Carlos A.; V, Priscila K. Mota; FERREIRA, Daniel B.; COHEN, David J.; MURTA, Claudio B.; CLARO, Joaquim F. A.; GIUSTI, Guido; MONGA, Manoj; NAHAS, William C.; SROUGI, Miguel; MAZZUCCHI, EduardoPurpose: High-quality evidence comparing supine to prone percutaneous nephrolithotomy (PCNL) for the treatment of complex stones is lacking. This study aimed to compare the outcomes of supine position (SUP) and prone position (PRO) PCNL. Materials and Method: A noninferior randomized controlled trial was per formed according to the CONSORT (Consolidated Standards for Reporting Trials) criteria. The inclusion criteria were patients over 18 years of age with complex stones. SUP was performed in the Barts flank-free modified position. Except for positioning, all the surgical parameters were identical. The primary outcome was the difference in the success rate on the first postoperative day (POD1) between groups. The secondary outcome was the difference in the stone-free rate (SFR) on the 90th postoperative day (final SFR). A non-inferiority margin of 15% was used. Demographic, operative, and safety variables were compared between the groups. Statistical significance was set at p <0.05. Results: Overall, 112 patients were randomized and their demographic characteristics were comparable. The success rates on POD1 were similar (SUP: 62.5% vs PRO: 57.1%, p = 0.563). The difference observed (-5.4%) was lower than the predefined limit. The final SFRs were also similar (SUP: 55.4% vs PRO: 50.0%, p =0.571). SUP had a shorter operative time (mean +/- SD 117.9 +/- 39.1 minutes vs 147.6 +/- 38.8 minutes, p <0.001) and PRO had a higher rate of Clavien >= 3 complications (14.3% vs 3.6%, p =0.045). Conclusions: Positioning during PCNL for complex kidney stones did not impact the success rates; consequently, both positions may be suitable. However, SUP might be associated with a lower high-grade complication rate.
- Reply by Authors(2022) PERRELLA, R.; VICENTINI, F. C.; PARO, E. D.; TORRICELLI, F. C. M.; MARCHINI, G. S.; DANILOVIC, A.; BATAGELLO, C. A.; MOTA, P. K. V.; FERREIRA, D. B.; COHEN, D. J.; MURTA, C. B.; CLARO, J. F. A.; GIUSTI, G.; MONGA, M.; NAHAS, W. C.; SROUGI, M.; MAZZUCCHI, E.
conferenceObject BLOOD-BASED BIOMARKERS AS PREDICTORS OF ONCOLOGIC OUTCOMES FOR NON-MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA(2017) CHADE, Daher; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; AREAS, Flavio; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; SHARIAT, Shahrokh; BASTOS, Diogo; DZIK, Carlos; SROUGI, Miguel; NAHAS, William