RAFAEL ANTONIO ARRUDA PECORA
Projetos de Pesquisa
Unidades Organizacionais
5 resultados
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- Transplante de intestino delgado(2013) PÉCORA, Rafael Antonio Arruda; DAVID, André Ibrahim; LEE, André Dong; GALVÃO, Flávio Henrique; CRUZ-JUNIOR, Ruy Jorge; D'ALBUQUERQUE, Luiz Augusto CarneiroBACKGROUND: Small bowel transplantation evolution, because of its complexity, was slower than other solid organs. Several advances have enabled its clinical application. AIM: To review intestinal transplantation evolution and its current status. METHOD: Search in MEDLINE and ScIELO literature. The terms used as descriptors were: intestinal failure, intestinal transplantation, small bowel transplantation, multivisceral transplantation. Were analyzed data on historical evolution, centers experience, indications, types of grafts, selection and organ procurement, postoperative management, complications and results. CONCLUSION: Despite a slower evolution, intestinal transplantation is currently the standard therapy for patients with intestinal failure and life-threatening parenteral nutrition complications. It involves some modalities: small bowel transplantation, liver-intestinal transplantation, multivisceral transplantation and modified multivisceral transplantation. Currently, survival rate is similar to other solid organs. Most of the patients become free of parenteral nutrition.
- Liver transplantation: Fifty years of experience(2014) SONG, Alice Tung Wan; AVELINO-SILVA, Vivian Iida; PECORA, Rafael Antonio Arruda; PUGLIESE, Vincenzo; D'ALBUQUERQUE, Luiz Augusto Carneiro; ABDALA, EdsonSince 1963, when the first human liver transplantation (LT) was performed by Thomas Starzl, the world has witnessed 50 years of development in surgical techniques, immunosuppression, organ allocation, donor selection, and the indications and contraindications for LT. This has led to the mainstream, wellestablished procedure that has saved innumerable lives worldwide. Today, there are hundreds of liver transplant centres in over 80 countries. This review aims to describe the main aspects of LT regarding the progressive changes that have occurred over the years. We herein review historical aspects since the first experimental studies and the first attempts at human transplantation. We also provide an overview of immunosuppressive agents and their potential side effects, the evolution of the indications and contraindications of LT, the evolution of survival according to different time periods, and the evolution of methods of organ allocation.
bookPart Transplant de intestino delgado(2016) GALVãO, Flávio Henrique Ferreira; LEE, André Dong Won; PéCORA, Rafael António de Arruda; D'ALBUQUERQUE, Luiz Augusto Carneiro- The Effects of Profound Hypothermia on Pancreas Ischemic Injury A New Experimental Model(2014) ROCHA-SANTOS, Vinicius; FERRO, Oscar Cavalcante; PANTANALI, Carlos Andres; SEIXAS, Marcel Povlovistsch; PECORA, Rafael Antonio Arruda; PINHEIRO, Rafael Soares; CLARO, Laura Carolina Lopez; ABDO, Emilio Elias; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz Augusto CarneiroObjective: Pancreatic ischemia-reperfusion (IR) has a key role in pancreas surgery and transplantation. Most experimental models evaluate the normothermic phase of the IR. We proposed a hypothermic model of pancreas IR to evaluate the benefic effects of the cold ischemic phase. Methods: We performed a reproducible model of hypothermic pancreatic IR. The ischemia was induced in the pancreatic tail portion (1-hour ischemia, 4-hour reperfusion) in 36 Wistar rats. They are divided in 3 groups as follows: group 1 (control), sham; group 2, normothermic IR; and group 3, hypothermic IR. In group 3, the temperature was maintained as close to 4.5-C. After reperfusion, serum amylase and lipase levels, inflammatory mediators (tumor necrosis factor alpha, interleukin 6), and pancreas histology were evaluated. Results: In pancreatic IR groups, amylase, cytokines, and histological damage were significantly increased when compared with group 1. In the group 3, we observed a significant decrease in tumor necrosis factor alpha (P = 0.004) and interleukin 6 (P = 0.001) when compared with group 2. We did not observe significant difference in amylase (P = 0.867), lipase (P = 0.993), and histology (P = 0.201). Conclusions: In our experimental model, we reproduced the cold phase of pancreas IR, and the pancreas hypothermia reduced the inflammatory mediators after reperfusion.
conferenceObject Home Parenteral Nutrition: the Experience of a Tertiary Hospital in Sao Paulo, Brazil.(2015) ROCHA, Mariana Hollanda Martins da; LEE, Andre Dong Won; DIAS, Maria Carolina Goncalves; WAITZBERG, Dan Linetzky; CATALANI, Lidiane Aparecida; GUIDI, Paula Machado; MICHELONI, Natalia Diniz; PECORA, Rafael Antonio Arruda; CALIL, Igor Lepski; GALVAO, Flavio Henrique Ferreira; D'ALBUQUERQUE, Luiz Augusto Carneiro