REGINA MARIA DE CARVALHO PINTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
- High-intensity interval training (HIIT) versus constant-load exercise (CLE) on the short-acute beta agonist (SABA) consumption and peak-expiratory flow (PEF) in subjects with moderate to severe asthma(2023) SILVA, Ronaldo Aparecido Da; FERNANDES, Thiago; STELMACH, Rafael; CUKIER, Alberto; CARVALHO-PINTO, Regina Maria; CARVALHO, Celso R. F.
- Increased physical activity reduces sleep disturbances in asthma: A randomized controlled trial(2023) PASSOS, Natalia Febrini; FREITAS, Patricia D.; CARVALHO-PINTO, Regina Maria; CUKIER, Alberto; CARVALHO, Celso R. F.Background and objective Individuals with asthma are more likely to develop sleep-disordered breathing. Exercise training improves sleep; however, the effect of physical activity (PA) on improving sleep quality remains unknown. This study had two objectives: (i) to evaluate the effect of a behavioural intervention to increase physical activity in daily living (PADL) on sleep quality in adults with asthma; (ii) to verify the association between a change in sleep quality, quality of life, anxiety, depression and asthma symptoms. Methods This randomized controlled clinical trial included adults physically inactive with asthma. Participants were randomized into the control (CG; n = 25) and intervention groups (IG; n = 24). IG was submitted to a behavioural intervention to increase PADL, and CG received the usual care. Pre- and post-intervention assessments of sleep quality (by actigraphy and questionnaire), PADL level (by accelerometry), asthma control, health-related quality of life and anxiety and depression levels were conducted. Results Both groups were similar at baseline. After the intervention, IG increased daily steps and moderate to vigorous PA levels. IG also improved sleep efficiency and latency as well as increased asthma-symptom-free days compared to CG. In addition, a greater proportion of participants in the IG had improved sleep quality after the intervention. Lastly, IG presented clinical improvement in the asthma-related quality of life questionnaire and a reduction in anxiety symptoms. Conclusion Our results demonstrate that a behavioural intervention can increase PA, enhance behavioural sleep quality, efficiency and quality of life and reduce asthma and anxiety symptoms.
- Postural balance assessment in fallers individuals with COPD before and after physical effort(2023) CENSO, Caroline Maschio de; PASSINI, Viviane Vieira; VERRI, Barbara Aparecida Teodoro Alcantara; PINTO, Regina Maria De Carvalho; STELMACH, Rafael; XAVIER, Rafaella Fagundes; LORENZI-FILHO, Geraldo; CARVALHO, Celso Ricardo Fernandes De
bookPart Doença pulmonar obstrutiva crônica(2023) PINTO, Regina Maria de Carvalho; MAIA, Ana Luisa Pimentel; SANCHEZ, Débora Santanin; FREITAS, Leonardo Vinicius de- Identifying the Characteristics of Responders and Nonresponders in a Behavioral Intervention to Increase Physical Activity Among Patients With Moderate to Severe Asthma: Protocol for a Prospective Pragmatic Study(2023) LIMA, Fabiano Francisco de; LUNARDI, Adriana Claudia; PINHEIRO, David Halen Araujo; CARVALHO-PINTO, Regina Maria; STELMACH, Rafael; GIAVINA-BIANCHI, Pedro; AGONDI, Rosana Camara; CARVALHO, Celso R. F.Background: Previous research has suggested that most adults improve their asthma control after a short-term behavioral intervention program to increase physical activity in daily life (PADL). However, the characteristics of individuals who respond and do not respond to this intervention and the medium-term response remain unknown.Objective: This study aims to (1) identify the characteristics of adult responders and nonresponders with asthma to a behavioral intervention to increase physical activity and (2) evaluate the functional and clinical benefits in the medium term.Methods: This prospective pragmatic study will include adults with moderate to severe asthma who enroll in a behavioral intervention. All individuals will receive an educational program and an 8-week intervention to increase PADL (1 time/wk; up to 90 min/session). The educational program will be conducted in a class setting through group discussions and video presentations. Behavioral interventions will be based on the transtheoretical model using counseling, incentives, and individual feedback aiming to increase participation in physical activity. Motivational interviewing and guidelines for overcoming barriers will be used to stimulate individuals to reach their goals. Pre-and postintervention assessments will include the following: PADL (triaxial accelerometry), body composition (octopolar bioimpedance), barriers to PADL (questionnaire), clinical asthma control (Asthma Control Questionnaire), quality of life (Asthma Quality of Life Questionnaire), anxiety and depression levels (Hospital Anxiety and Depression Scale), and exacerbations. ""Responders"" to the intervention will be defined as those who demonstrate an increase in the number of daily steps (& GE;2500). Results: In December 2021, the clinical trial registration was approved. Recruitment and data collection for the trial is ongoing, and the results of this study are likely to be published in late 2024. Conclusions: The intervention will likely promote different effects according to the clinical characteristics of the individuals, including asthma control, age, anxiety and depression levels, obesity, and several comorbidities. Identifying individuals who respond or do not respond to behavioral interventions to increase PADL will help clinicians prescribe specific interventions to adults with asthma.Trial Registration: ClinicalTrials.gov NCT05159076; https://clinicaltrials.gov/ct2/show/NCT05159076International Registered Report Identifier (IRRID): DERR1-10.2196/49032
- Human peripheral blood age-associated (CD11c+Tbet+) B cells: No association with age(2023) PINTO, Thalyta Nery Carvalho; SILVA, Cibele Cristine Berto Marques da; PINTO, Regina Maria Carvalho; DUARTE, Alberto Jose da Silva; BENARD, Gil; FERNANDES, Juliana Ruiz
- Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis(2023) ENDRIGUE, Tiago C.; LUNARDI, Adriana C.; FREITAS, Patricia D.; SILVA, Ronaldo A.; MENDES, Felipe A. R.; FRANCA-PINTO, Andrezza; CARVALHO-PINTO, Regina M.; CARVALHO, Celso R. F.Objective: To determine the characteristics of individuals with asthma who are responsive to aerobic training. Methods: This post hoc analysis of pooled data from previous randomized controlled trials involved 101 individuals with moderate to severe asthma who underwent aerobic training. Participants underwent a maximal cardiopulmonary exercise test and completed the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire before and after a 24-session aerobic training program. Better and worse responders to aerobic training were identified by cluster analysis. Results: Two clusters were identified according to the improvement in peak VO2 after aerobic training (better and worse responders). Characteristics of the better responder group were being older, being female, having higher BMI, and having higher cardiac reserve at baseline when compared with the worse responder group. Also, better responders had worse clinical control, worse quality of life, and lower physical capacity at baseline. After training, worse responders, in comparison with better responders, showed half the improvement in Delta peak VO2 ( 7.4% vs. 13.6%; 95% CI, -12.1 to - 0.92%; p < 0.05) and worse asthma control. A weak, negative, but significant association (r = -0.35; p < 0.05) was observed between clinical control and aerobic fitness only in the better responder group. Both groups showed significant improvement in quality of life. Conclusions: Obese individuals with worse exercise capacity, clinical control, and quality of life showed improvement with aerobic training. Moreover, worse responders also improved with training, but to a lesser extent.
- Diaphragmatic mobility assessed by ultrasound is associated with thoracoabdominal asynchrony in severe to very severe COPD patients(2023) SANTOS, Juliana M. B.; REIS, Estefane C. M.; LINO, Pedro L.; LUNARDI, Adriana C.; SILVA, Cibele C. B. M.; PINTO, Thiago F.; CARVALHO-PINTO, Regina M.; CUKIER, Alberto; CHAMMAS, Maria C.; CARVALHO, Celso R. F.
- Asthma and pregnancy(2023) CARVALHO-PINTO, Regina Maria de; CANCADO, Jose Eduardo Delfini; CAETANO, Lilian Serrasqueiro Ballini; MACHADO, Adelmir Souza; BLANCO, Daniela Cavalet; GARCIA, Guilherme Freire; FIGUEIREDO, Ricardo Gassmann; BARTHOLO, Thiago Prudente
- Asthma in Brazil: an epidemiological analysis from 2008 to 2021(2023) PINHEIRO, David Halen Araujo; SOUZA, Joao Victor Hermogenes De; LIMA, Fabiano Francisco De; JUSTO, Alberto Fernando Oliveira; CERVERA, Vitoria Zacarias; CARVALHO-PINTO, Regina Maria; CARVALHO, Celso R. F.