MARINA ALESSANDRA PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- TUMOR MARKERS EXPRESSION LEVELS IN GASTRIC CANCER PATIENT'S PERIPHERAL BLOOD BY RT-PCR ASSESSMENT(2023) KAWAKAMI, Gabriel da Silva; PEREIRA, Marina Alessandra; KUBRUSLY, Marcia Saldanha; CARRASCO, Alexis German Murillo; RAMOS, Marcus Fernando Kodama Pertille; JR, Ulysses RibeiroBACKGROUND: Hematological recurrence is the second most frequent cause of failure in the treatment of gastric cancer. The detection of circulating tumor markers in peripheral blood by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) method may be a useful tool to predict recurrence and determine the patient's prognosis. However, no consensus has been reached regarding the association between the tumor markers level in peripheral blood and its impact on patient survival. AIMS: To evaluate the expression of the circulating tumor markers CK20 and MUC1 in peripheral blood samples from patients with gastric cancer by qRT-PCR, and to verify the association of their expression levels with clinicopathological characteristics and survival. METHODS: A total of 31 patients with gastric adenocarcinoma were prospectively included in this study. CK20 and MUC1 expression levels were analyzed from peripheral blood by the qRT-PCR technique. RESULTS: There was no statistically significant (p>0.05) association between CK20 expression levels and clinical, pathological, and surgical features. Higher MUC1 expression levels were associated with female patients (p=0.01). There was a correlation between both gene levels (R=0.81, p<0.001), and CK20 level and tumor size (R=0.39, p=0.034). CONCLUSIONS: CK20 and MUC1 expression levels could be assessed by qRT-PCR from total peripheral blood samples of patients with gastric cancer. CK20 levels were correlated to MUC1 levels as well as to tumor size. There was no difference in disease-free survival and overall survival regarding both genetic markers expression in this series
- INTRAPERITONEAL CHEMOTHERAPY FOR GASTRIC CANCER WITH PERITONEAL CARCINOMATOSIS: STUDY PROTOCOL OF A PHASE II TRIAL(2023) RAMOS, Marcus Fernando Kodama Pertille; PEREIRA, Marina Alessandra; CHARRUF, Amir Zeide; VICTOR, Carolina Ribeiro; GREGORIO, Joao Vitor Antunes Marques; ALBAN, Luciana Bastos Valente; MONIZ, Camila Motta Venchiarutti; ZILBERSTEIN, Bruno; MELLO, Evandro Sobroza De; HOFF, Paulo Marcelo Gehm; JUNIOR, Ulysses Ribeiro; DIAS, Andre RonconBackground: Peritoneal carcinomatosis in gastric cancer is considered a fatal disease, without expectation of definitive cure. As systemic chemotherapy is not sufficient to contain the disease, a multimodal approach associating intraperitoneal chemotherapy with surgery may represent an alternative for these cases.Aims: The aim of this study was to investigate the role of intraperitoneal chemotherapy in stage IV gastric cancer patients with peritoneal metastasis.Methods: This study is a single institutional single-arm prospective clinical trial phase II (NCT05541146). Patients with the following inclusion criteria undergo implantation of a peritoneal catheter for intraperitoneal chemotherapy: Stage IV gastric adenocarcinoma; age 18-75 years; Peritoneal carcinomatosis with peritoneal cancer index<12; Eastern Cooperative Oncology Group 0/1; good clinical status; and lab exams within normal limits. The study protocol consists of four cycles of intraperitoneal chemotherapy with paclitaxel associated with systemic chemotherapy. After treatment, patients with peritoneal response assessed by staging laparoscopy undergo conversion gastrectomy.Results: The primary outcome is the rate of complete peritoneal response. Progression-free and overall survivals are other outcomes evaluated. The study started in July 2022, and patients will be screened for inclusion until 30 are enrolled.Conclusions: Therapies for advanced gastric cancer patients have been evaluated in clinical trials but without success in patients with peritoneal metastasis. The treatment proposed in this trial can be promising, with easy catheter implantation and ambulatory intraperitoneal chemotherapy regime. Verifying the efficacy and safety of paclitaxel with systemic chemotherapy is an important progress that this study intends to investigate.
- PALLIATIVE GASTRECTOMY VERSUS GASTRIC BYPASS FOR SYMPTOMATIC CLINICAL STAGE IV GASTRIC CANCER: A PROPENSITY SCORE MATCHING ANALYSIS(2023) PINTO, Sterphany Ohana Soares Azevedo; PEREIRA, Marina Alessandra; JR, Ulysses Ribeiro; D'ALBUQUERQUE, Luiz Augusto Carneiro; RAMOS, Marcus Fernando Kodama PertilleBACKGROUND: Patients with clinical stage IV gastric cancer may require palliative procedures to manage complications such as obstruction. However, there is no consensus on whether performing palliative gastrectomy compared to gastric bypass brings benefits in terms of survival. AIMS: To compare the overall survival of patients with distal obstructive gastric cancer undergoing palliative surgical treatment, using propensity score matching analysis. METHODS: Patients who underwent palliative bypass surgery (gastrojejunostomy or partitioning) and resection between the years 2009 and 2023 were retrospectively selected. Initial and postoperative clinicopathological variables were collected. RESULTS: 150 patients were initially included. The derived group (n=91) presented more locally invasive disease (p<0.01), greater degree of obstruction (p<0.01), and worse clinical status (p<0.01), while the resected ones (n= 59) presented more distant metastasis (p<0.01). After matching, 35 patients remained in each group. There was no difference in the incidence of postoperative complications, but the derived group had higher 90-day mortality (p<0.01). Overall survival was 16.9 and 4.5 months for the resected and derived groups, respectively (p<0.01). After multivariate analysis, hypoalbuminemia (hazard ratio - HR=2.02, 95% confidence interval - 95%CI 1.17-3.48; p=0.01), absence of adjuvant chemotherapy (HR=5.97; 95%CI 3.03-11.7; p<0.01), and gastric bypass (HR=3,28; 95%CI 1.8-5.95; p<0.01) were associated with worse survival. CONCLUSIONS: Palliative gastrectomy was associated with greater survival and lower postoperative morbidity compared to gastric bypass. This may be due to better local control of the disease, with lower risks of complications and better effectiveness of chemotherapy.
- FAILURE TO RESCUE AFTER GASTRECTOMY: A NEW INDICATOR OF SURGICAL QUALITY(2023) HONG, Stefany; PEREIRA, Marina Alessandra; DIAS, Andre Roncon; JR, Ulysses Ribeiro; D'ALBUQUERQUE, Luiz Augusto Carneiro; RAMOS, Marcus Fernando Kodama PertilleBackground: The main treatment modality for gastric cancer is surgical resection with lymphadenectomy. Despite advances in perioperative care, major surgical complications can occur in up to 20% of cases. To determine the quality of surgical care employed, a new indicator called failure to rescue (FTR) was proposed, which assesses the percentage of patients who die after complications occur.Aims: To assess the rate of FTR after gastrectomy and factors associated with its occurrence.Methods: Patients with gastric cancer who underwent gastrectomy with curative intent were retrospectively evaluated. According to the occurrence of postoperative complications, patients were divided into FTR group (grade V complications) and rescued group (grade III/IV complications).Results: Among the 731 patients, 114 had major complications. Of these patients, 76 (66.7%) were successfully treated for the complication (rescued group), while 38 (33.3%) died (FTR group). Patients in the FTR group were older (p=0.008; p<0.05), had lower levels of hemoglobin (p=0.021; p<0.05) and albumin (p=0.002; p<0.05), and a higher frequency of ASA III/IV (p=0.033; p<0.05). There were no differences between the groups regarding surgical and pathological characteristics. Clinical complications had a higher mortality rate (40.0% vs 30.4%), with pulmonary complications (50.2%) and infections (46.2%) being the most lethal. Patients with major complications grade III/IV had worse survival than those without complications.Conclusions: The FTR rate was 33.3%. Advanced age, worse performance, and nutritional parameters were associated with FTR.
- STAGING LAPAROSCOPY IS STILL A VALUABLE TOOL FOR OPTIMAL GASTRIC CANCER MANAGEMENT(2022) SAKAMOTO, Erica; RAMOS, Marcus Fernando Kodama Pertille; PEREIRA, Marina Alessandra; DIAS, Andre Roncon; RIBEIRO JUNIOR, Ulysses; ZILBERSTEIN, Bruno; NAHAS, Sergio CarlosComplete surgical resection is the main determining factor in the survival of advanced gastric cancer patients, but is not indicated in metastatic disease. The peritoneum is a common site of metastasis and preoperative imaging techniques still fail to RESUMO -Racional: O tratamento de escolha para pacientes com hipertensao portal detect it. AI M: The aim of this study was to evaluate the role of staging laparoscopy in the esqustossomotica com sangramento de vriz e a desconexao azigo-portal mais staging of advanced gastric cancer patients in a Wes tern tertiary cancer center. METHODS: A total oesplenectomiaf 130 p atie(DAPE)nts with gassociadaastric aa denterapiocarcinmendoscopica.a who undPorem,erwe nt sestudostagin g lamostrmparos copyaumento from do calibre das varizes em alguns pacientes durante o seguimeto em lngo prazo. Objtivo: 2009 to 2020 were evaluated from a prospective database. Clinicopathological characteristics Avaliar o impacto da DAPE e tratamento endoscopico pos-operatorio no comportamento were analyzed to identify factors associated with the presence of peritoneal metastasis and were also evaluated the accuracy and strength of agreement between computed das varizes esofagicas e recidiva hemorragica, de pacientes esquistossomoticos. Metodos: tomography and staging laparoscopy in detecting peritoneal metastasis and the change in Form sudados 36 pacientes om seguimento superio a cinco anos, distribuios em treatment strategy after the procedure. RESULTS: The peritoneal metastasis was identified indois 6 6 (5grupos:0.76 %) quedapati edant s. Thpressaoe se nsiportaltivit y, sabaixopec ifideci ty,30% an ed acimacura cdey of30% co mputecomparadosd tom ogcomrap ho y calibre das varizes esofagicas no pos-operatorio precoce e tardio alem do indie e recidiva in detecting peritoneal metastasis were 51.5, 87.5, and 69.2%, respectively. According to the hemorragica. Resultados Kappa coefficient, the concordance between staging laparoscopy and computed tomography was 38.8%. In multivariate analysis, ascites (p=0.001) and suspected peritoneal metastasis on esofagicas que, durante o seguimento aumentaram de calibre e foram controladas com computed tomography (p=0.007) were statistically correlated with peritoneal metastasis. In 40 (30.8%) patients, staging and treatment plans changed after staging laparoscopy (32 patients oa vided ucomportamentonnecessa rydo l apacalibreroto mdasy, andvarizes 8 p atnoie nts, whopos-operatorio were p revioprecoceusly conemnsi detardioed stanemge IVos b indies de recidiva hemorragica. Conclusao by computed tomography, were referred to surgical treatment). CONCLUSION: The staging laparoscopy demonstrated an important role in the diagnosis of peritoneal metastasis, even with current advances in imaging techniques.
- PREOPERATIVE CHEMOTHERAPY VERSUS UPFRONT SURGERY FOR ADVANCED GASTRIC CANCER: A PROPENSITY SCORE MATCHING ANALYSIS(2023) HONG, Stefany; PEREIRA, Marina Alessandra; VICTOR, Carolina Ribeiro; GREGORIO, Joao Vitor Antunes; ZILBERSTEIN, Bruno; RIBEIRO JUNIOR, Ulysses; D'ALBUQUERQUE, Luiz Augusto Carneiro; RAMOS, Marcus Fernando Kodama PertilleBACKGROUND: Surgical resection remains the main curative therapeutic modality for RESUMO -Racional: O tratamento de escolha para pacientes com hipertensao portal advanced gastric cancer. Recently, the association of preoperative chemotherapy has allowed the improvement of results without increasing surgical complications. AIMS: To evaluate the surgical esquistossomotica com sangramento de varizes e a desconexao azgo-portal mais and oncological outcomes of preoperative chemotherapy in a real-world setting. METHODS: A esplenectomia (DAPE) associada a trai doscopica. Porem, estudos ostrm aumento retrospective review of gastric cancer patients who underwent gastrectomy was performed. do calibre das varizes em alguns pacientes durante segimento em lngo prazo. Objetivo: Patients were divided into two groups for analysis: upfro nt surgery and preoperative chemotherapy. Avaliar o impacto da DAPE e tratamento endoscopico pos-operatorio no comportameno The propensity score matching analysis, including 9 variables, was applied to adjust for potential das varizes esofagicas e recidiva hemorragica, de pacientes esquistossomoticos. Metodos: confounding factors. RESULTS: Of the 536 patients included, 112 (20.9%) were referred for preoperative chemotherapy. Before the propensity score matching analysis, the groups were Foram estudados 36 pacientes com seguimento superior a cinco anos, distribuidos em different in terms of age, hemoglobin level, node metastasis at clinical stage-status, and extent dois grupos: queda da pressao portal abaixo de 30% e acima de 30% comparados com o of gastrectomy. After the analysis, 112 patients were stratified for each group. Both were similar calibre ds varize esofagicas no pos-operaorio precoce tardio ale do indice de reciiva for all variables assigned in the score. Patients in the preope rative chemotherapy group had less hemorragica. Resultados advanced postoperative p staging (p=0.010), postoperative n staging (p<0.001), and pTNM stage esofagicas que, durante o seguimento aumentaram de calibre e foram controladas com (p<0.001). Postoperative complications, 30-and 90-days mortality were similar between both groups. Before the propensity score matching analysis, there was no difference in survival between the groups. After the analysis, patients in the preoperative chemotherapy group had better overall o comportamento do calibre das varizes no pos-operatorio precoce nem tardio nm os survival compared to upfront surgery group (p=0.012). Multivariate analyses demonstrated that indices de recidiva hemorragica. Conclusao American Society of Anesthesiologists III/IV category and the presence of lymph node metastasis were factors significantly associated with worse overall survival. CONCLUSIONS: Preoperative operatorios precoces ou tardios. A comparacao entre a queda de pressao do portal e as chemotherapy was associated with increased survival in gastric cancer. There was no difference in the postoperative complication rate and mortality compared to upfront surgery.