ELEAZAR CHAIB
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Gastroenterologia, Faculdade de Medicina - Docente
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/37 - Laboratório de Transplante e Cirurgia de Fígado, Hospital das Clínicas, Faculdade de Medicina - Líder
39 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 39
- Translational Research for Pelvic Floor Transplantation(2017) GALVAO, Flavio; WAISBERG, Daniel; SEID, Victor; CRUZ, Ruy; TRALDI, Maria; ARAUJO, Bruno; PANTANALI, Carlos; ANDRAUS, Wellington; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz
conferenceObject A new Model of Hipothermic Pancreas Ischemia-Reperfusion in Rats(2013) SANTOS, Vinicius; FERRO, Oscar; PANTANALI, Carlos; ARANTES, Rubens; PECORA, Rafael; DAVID, Andre; CHAIB, Eleazar; D'ALBUQUERQUE, LuizconferenceObject Hyperacute Rejection in Multivisceral Xenotransplantation(2012) GALVAO, F.; SOLER, W.; POMPEU, E.; COSTA, A.; WAISBERG, D.; CAPELLOZI, V.; TEODORO, W.; VELOSA, A.; CHAIB, E.; D'ALBUQUERQUE, L.conferenceObject Pelvic Floor Transplantation in The Reat.(2014) GALVAO, F.; BAPTISTA, R.; SEID, V.; WAISBERG, D.; RODRIGUES, P.; CHAIB, E.; D'ALBUQUERQUE, L.- Bile duct confluence: anatomic variations and its classification(2014) CHAIB, Eleazar; KANAS, Alexandre Fligelman; GALVAO, Flavio Henrique Ferreira; D'ALBUQUERQUE, Luiz Augusto CarneiroAccurate knowledge of the anatomy of the bile ducts is critical for successfully hepato-biliary surgery. We describe the anatomical variations of the confluence of the bile ducts, their branches patterns, frequency and classification. From 1996 to 2011, we have collected data of the bile duct confluence. 2,032 and 1,014 anatomical variations of right and left bile ducts, respectively, were reviewed and classified according to the branching pattern. The frequencies of each type of the right hepatic duct (RHD) were as follows: Type A1-1,247 (61.3 %); Type A2-296 (14.5 %); Type A3-272 (13.3 %); Type A4-124 (6.1 %); Type A5-21 (1 %) and others-72 (3.5 %) and, for the left hepatic duct (LHD) was as follows: Type B1-773 (76.2 %); Type B2-153 (15 %); Type B3-38 (3.7 %); Type B4-9 (0.8 %); Type B5-29 (2.8 %) and others-12 (1.1 %). Atypical branching patterns of both the right and left hepatic ducts were found in 14 and 8 %, respectively. The two most common variations of the RHD were right anterior and posterior hepatic ducts join together to form the RHD and trifurcation where the RHD is absent and right anterior and posterior hepatic ducts join directly to the confluence with the LHD to form the common hepatic duct. The two most common variations in the LHD were segment IV drainage to the left and right hepatic ducts.
- Does anti-hepatitis B virus vaccine make any difference in long-term number of liver transplantation?(2012) CHAIB, E.; COIMBRA, B. G. M. M.; GALVAO, F. H. F.; TATEBE, E. R.; SHINZATO, M. S.; D'ALBUQUERQUE, L. A. C.; MASSAD, E.Background: Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality worldwide. Chronic hepatitis B infection is associated with an increased risk of cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Our aim is to analyze, through a mathematical model, the potential impact of anti-HBV vaccine in the long-term (that is, decades after vaccination) number of LT. Methods: The model simulated that the prevalence of HBV infection was 0.5% and that approximately 20% of all the liver transplantation carried out in the state of Sao Paulo are due to HBV infection. Results: The theoretical model suggests that a vaccination program that would cover 80% of the target population would reach a maximum of about 14% reduction in the LT program. Conclusion: Increasing the vaccination coverage against HBV in the state of Sao Paulo would have a relatively low impact on the number of liver transplantation. In addition, this impact would take several decades to materialize due to the long incubation period of liver failure due to HBV.
conferenceObject Human Islet Transplantation: An Overview.(2014) SANGALLI, B.; BARROS, E.; RAINKOBER, P.; D'ALBUQUERQUE, L.; CHAIB, E.- Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection(2012) MARQUES, Thamirys Guimaraes; CHAIB, Eleazar; FONSECA, Juliana Hamati da; LOURENCO, Ana Cecilia Rodrigues; SILVA, Felipe Duarte; RIBEIRO JR., Marcelo Augusto Fontenelle; GALVAO, Flavio Henrique Ferreira; D'ALBUQUERQUE, Luiz Augusto CarneiroPURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content ""induction of liver cirrhosis in rats"". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.
conferenceObject INTRAHEPATIC BILE DUCTS: ANATOMIC VARIATIONS, CLASSIFICATION AND CLINICAL APPLICATION FOR LIVING DONOR LIVER TRANSPLANTATION(2013) CHAIB, Eleazar; KANAS, Alexandre F.- Atividade da mieloperoxidase está aumentada na síndrome hepatopulmonar em ratos(2013) NACIF, Lucas Souto; ANDRAUS, Wellington; KUBRUSLY, Márcia Saldanha; MOLAN, Nilza; CHAIB, Eleazar; D'ALBUQUERQUE, Luiz Augusto CarneiroBACKGROUND: Hepatopulmonary syndrome is formed by a triad of liver disease, intrapulmonary vascular dilatation and changes in blood gases. Its pathogenesis is not well defined, but it is speculated that a combination of factors, such as the imbalance of endothelin receptor responses, pulmonary microvascular remodeling, and genetic predisposition, leads to bacterial translocation and intrapulmonary vascular dilatation. AIM: To evaluate the myeloperoxidase activity in hepatopulmonary syndrome in rat model. METHOD: Twenty-nine rats were divided into control, sham and experimental hepatopulmonary syndrome groups. Was evaluated the myeloperoxidase activity and the experimental model used to induce hepatopulmonary syndrome was common bile duct ligation. RESULTS: The myeloperoxidase activity levels were significantly increased in the common bile duct ligation group as compared with the other groups. Myeloperoxidase activity was higher in the common bile duct ligation group than control group (p<0.05) and than sham group (p<0.05). CONCLUSION: The myeloperoxidase activity is increased in experimental hepatopulmonary syndrome in rats.