PAULA SILVA FERREIRA
Projetos de Pesquisa
Unidades Organizacionais
5 resultados
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- In Vivo Reflectance Confocal Microscopy of Adnexal Tumors: Evaluation of Trichoepithelioma, Sebaceoma, and Fibrofolliculoma(2022) ROSALES-DURAN, Sharon; RICAURTE-JIMENEZ, Marcela; FERREIRA, Paula S.; SANGUEZA, Martin; V, Silvia Lourenco; NICO, Marcello M. S.Cutaneous adnexal tumors are benign and malignant neoplasms that undergo morphological differentiation into cutaneous adnexa, comprising pilosebaceous, eccrine, or apocrine units. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues at a similar resolution as conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, potentiating its wide application, especially for benign and malignant skin tumors. We describe the use of reflectance confocal microscopy in cases of trichoepithelioma, sebaceoma, and fibrofolliculoma and correlate the resulting clinical, histopathological, and confocal microscopy images.
- Reflectance confocal microscopy (RCM)-based criteria for progression of lower-lip squamous cell carcinoma: A prospective study(2022) FERREIRA, Paula Silva; ROCHA, Lilian; BEZERRA, Ana Patricia Carneiro; NICO, Marcello Menta Simonsen; LOURENCO, Silvia VanessaBackground: Actinic cheilitis (AC) presents as a diffuse clinical-histopathological alteration throughout the lower lip. Objectives: To analyze AC lesions using reflectance confocal microscopy (RCM) and evaluate criteria for the early diagnosis of incipient squamous cell carcinoma (SCC). Methods: This prospective study comprised cases of clinically diagnosed AC. RCM was performed over the entire extension of the lower lip. The sites that showed the highest degree of morphological alteration by RCM, according to established criteria for AC and SCC, were biopsied. The RCM findings and histopathology were correlated to establish the precise and early diagnosis of SCC. Results: A total of 61 cases that had been clinically diagnosed with AC were included. The RCM findings that correlated independently with SCC were: nonedged papillae (sensitivity 84% and specificity 88%, p < 0.0001, and OR 42), cell-filled papillae (sensitivity 82% and specificity 93%, p < 0.0001, and OR 71.3), inflammation (sensitivity 68% and specificity 68%, p = 0.0163, and OR 4.8), large and roundish cells in the lamina propria (sensitivity 65% and specificity 100%, p < 0.0001, and OR infinity), and nests in the lamina propria (sensitivity 54% and specificity 100%, p < 0.0001, and OR infinity). An independent histopathological analysis classified the cases as partial epithelial dysplasia (25 cases, 41%) and SCC (36, 59%), and in 57 cases (94%), the results agreed with the categorization that was rendered by the RCM exam. Conclusions: RCM can be used to monitor AC cases, guide the biopsy site, and identify the early progression of AC to SCC with good sensitivity and specificity.
bookPart Dermatoses da hipoderme(2022) FERREIRA, Paula Silva- Dermatoscopic features of 67 excised melanocytic lesions in patients at high risk of cutaneous malignant melanoma in a Brazilian hospital(2022) ABED, N. M.; AVANCINI, J.; FERREIRA, P. S.; GUIMARãES, A. L. Monteiro; FESTA NETO, C.
- Dermoscopic features of 61 skin lesions in xeroderma pigmentosum patients: A cross-sectional study(2022) ROCHA, Lilian Kelly Faria Licariao; FERREIRA, Paula; AVANCINI, Joao; CASTRO, Ligia P.; NAJJAR, Zilda; RIVITTI-MACHADO, Maria C.; SAMORANO, Luciana Paula; BARBOSA, Caroline F.; COLACIQUE, Caroline; FESTA-NETO, Cyro