DANIELLE ELISE GILL

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LIM/46 - Laboratório de Parasitologia Médica, Hospital das Clínicas, Faculdade de Medicina

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  • article 8 Citação(ões) na Scopus
    Guapiacu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
    (2021) RIBEIRO, Geovani de Oliveira; COSTA, Antonio Charlys da; GILL, Danielle Elise; RIBEIRO, Edcelha Soares D'Athaide; REGO, Marlisson Octavio da S.; MONTEIRO, Fred Julio Costa; VILLANOVA, Fabiola; NOGUEIRA, Juliana Silva; MAEDA, Adriana Yurika; SOUZA, Renato Pereira de; TAHMASEBI, Roozbeh; MORAIS, Vanessa S.; PANDEY, Ramendra Pati; RAJ, V. Samuel; SCANDAR, Sirle Abdo Salloum; VASAMI, Fernanda Gisele da Silva; D'AGOSTINO, Leandro Guaraglia; MAIORKA, Paulo Cesar; DENG, Xutao; NOGUEIRA, Mauricio Lacerda; SABINO, Ester Cerdeira; DELWART, Eric; LEAL, Elcio; CUNHA, Mariana Sequetin
    Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiacu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3 ' UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.
  • article 5 Citação(ões) na Scopus
    Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon
    (2021) RIBEIRO, Geovani de Oliveira; GILL, Danielle Elise; RIBEIRO, Edcelha Soares D. Athaide; MONTEIRO, Fred Julio Costa; MORAIS, Vanessa S.; MARCATTI, Roberta; REGO, Marlisson Octavio da S.; ARAUJO, Emerson Luiz Lima; WITKIN, Steven S.; VILLANOVA, Fabiola; DENG, Xutao; SABINO, Ester Cerdeira; DELWART, Eric; LEAL, Elcio; COSTA, Antonio Charlys da
    Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapa. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapa around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapa isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.