WANDERLEY MARQUES BERNARDO
Projetos de Pesquisa
Unidades Organizacionais
FMUSP, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/47 - Laboratório de Hepatologia por Vírus, Hospital das Clínicas, Faculdade de Medicina
LIM/47 - Laboratório de Hepatologia por Vírus, Hospital das Clínicas, Faculdade de Medicina
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
- Guidelines Program of the Brazilian Medical Association(2019) BERNARDO, Wanderley Marques
- Revisão sistemática e a necessidade de condutas oftalmológicas baseadas em evidências(2016) CARRICONDO, Pedro Carlos; BARBOSA, Leonardo José; BERNARDO, Wanderley Marques
- Atualização em doença do refluxo gastroesofágico (DRGE): tratamento não farmacológico(2012) CARVALHAES, Aloisio; EISIG, Jaime Natan; RODRIGUEZ, Tomas Navarro; BERNARDO, Wanderley Marques
- PRISMA statement and PROSPERO(2017) BERNARDO, Wanderley Marques
- Birth route in case of cesarean section in a previous pregnancy(2015) SIMOES, Ricardo; BERNARDO, Wanderley M.; SALOMAO, Antonio J.; BARACAT, Edmund C.
- Antibiotics in the prophylaxis of COVID or in the treatment of mild COVID(2022) BARBOSA, Alexandre Naime; SILVINATO, Antonio; BACHA, Helio; FLORIANO, Idevaldo; TANNI, Suzana; BERNARDO, Wanderley
- Is sulfadiazine alone equivalent (benefit and harm) to spiramycin to treat acute toxoplasmosis in the first trimester of pregnancy?(2015) BERNARDO, Wanderley Marques; CHINZON, Miriam; CHAVES, Felipe Galvao Batista
- Public health policies and scientific evidence(2017) BERNARDO, Wanderley Marques
- Ipse Dixit(2020) BERNARDO, Wanderley
- Endoscopic biliary sphincterotomy: electric current mode(2022) FUNARI, Mateus Pereira; SAGAE, Vitor Massaro Takamatsu; MOURA, Eduardo Guimaraes Hourneaux de; BERNARDO, Wanderley MarquesINTRODUCTION Endoscopic retrograde cholangiopancreatography (ERCP) asso-ciated with biliary sphincterotomy is a procedure performed widely in medical practice. However, this intervention is not an exempt from complications (4-5%) such as acute pancreatitis, bleeding, perforation, cholangitis, or even death (0.02-0.4%)1-3. Several studies point to the correlation between the electric cur-rent mode (pure cut, blend, pulsed cut, or endocut, and pure cut followed by blend) used in endoscopic sphincterotomy and the inci-dence of adverse events4-6. A better knowledge of the subject based on evidence can assist us in making the best decision in clinical practice. Our objective is, through a systematic review and meta -anal-ysis, to trace the safety profile of each modality of electric cur-rent (pure cut, pulsed cut, blend cut, and pure cut followed by blend) employed in endoscopic biliary sphincterotomy to reduce the incidence of adverse events related to this procedure. METHODS A systematic review and meta-analysis of the literature (Medline, Central Cochrane, Embase, LILACS VHL, and grey litera-ture) were carried out according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) recommendations7. We used the PICO system (Patient: older than 18 years with the indication of ERCP and biliary sphinc-terotomy; Intervention and Control: respective modalities of electric current; and Outcome: adverse events such as acute pancreatitis, bleeding, perforation, and cholangitis). We selected only randomized controlled trials that included patients aged more than 18 years who underwent ERCP with biliary sphincterotomy for various causes (e.g., choledocholithiasis, obstructive neoplasia, benign strictures, and biliary fistulas) random-ized to any of the modalities of electric current under evaluation. The risk of bias in each study was assessed using the Cochrane bias risk tool8. The level of evidence for each outcome was eval-uated according to GRADE (Grading of Recommendations Assessment, Development and Evaluation)9. The data were meta-analyzed using the RevMan 5.3 soft-ware, and the results were revealed as forest plots. RESULTS After removing duplicates, 12,282 articles were screened, including 10 randomized clinical trials in our study4,10-18. Annex Figure 1 summarizes the selection process. The risk of bias in the included studies is expressed in Annex Table 1. The characteristics of the studies and results are presented in Chart 1. Results expressed by comparison: