MARIA CONCEPCION GARCIA OTADUY
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
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- Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy(2014) ANDRADE, Celi S.; LEITE, Claudia C.; OTADUY, Maria C. G.; LYRA, Katarina P.; VALENTE, Kette D. R.; YASUDA, Clarissa L.; BELTRAMINI, Guilherme C.; BEAULIEU, Christian; GROSS, Donald W.Purpose: Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that can characterize white matter (WM) architecture and microstructure. DTI has demonstrated extensive WM changes in patients with several epileptic syndromes, but few studies have focused on patients with malformations of cortical development (MCD). Our aim was to investigate the quantitative diffusion properties of the corpus callosum (CC), a major commissural bundle critical in inter-hemispheric connectivity, in a large group of patients with MCD. Methods: Thirty-two MCD patients and 32 age and sex-matched control subjects were evaluated with DTI at 3.0 T. We analyzed the three major subdivisions of the CC (genu, body, and splenium) with deterministic tractography to yield fractional anisotropy (FA), mean diffusivity (MD), parallel diffusivity (lambda parallel to) and perpendicular diffusivity (lambda perpendicular to). We further assessed the CC with region of interest (ROI)-based analyses and evaluated different subgroups of MCD (polymicrogyria/schizencephaly, heterotopia, and cortical dysplasia). Partial correlations between diffusion changes and clinical parameters (epilepsy duration and age at disease onset) were also queried. Results: There were significant reductions of FA, accompanied by increases in MD and lambda perpendicular to in all segments of the CC in the patients group with both analytical methods. The absolute differences in FA were greater on ROI-analyses. There were no significant differences between the MCD subgroups, and no correlations between clinical parameters of epilepsy and FA. Conclusions: Our study indicates DTI abnormalities consistent with microstructural changes in the corpus callosum of MCD patients. The findings support the idea that patients with epilepsy secondary to cortical malformations present widespread WM changes that extend beyond the macroscopic MRI-visible lesions.
- Comment on ""Cores of Reproducibility in Physiology (CORP): quantification of human skeletal muscle carnosine concentration by proton magnetic resonance spectroscopy""(2021) SILVA, Vinicius da Eira; MATTHEWS, Joseph; GUALANO, Bruno; PAINELLI, Vitor de Salles; OTADUY, Maria Concepcion; SALE, Craig; ARTIOLI, Guilherme Giannini
- Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group(2021) HAN, L. K. M.; DINGA, R.; HAHN, T.; CHING, C. R. K.; EYLER, L. T.; AFTANAS, L.; AGHAJANI, M.; ALEMAN, A.; BAUNE, B. T.; BERGER, K.; BRAK, I.; HENRY, C.; CASERAS, X.; CHAIM-AVANCINI, T. M.; ELVSåSHAGEN, T.; FAVRE, P.; FOLEY, S. F.; FULLERTON, J. M.; HOUENOU, J.; HOWELLS, F. M.; INGVAR, M.; COUVY-DUCHESNE, B.; KUPLICKI, R.; LAFER, B.; LANDéN, M.; FILHO, G. B.; MACHADO-VIEIRA, R.; MALT, U. F.; MCDONALD, C.; MITCHELL, P. B.; NABULSI, L.; OTADUY, M. C. G.; THOMPSON, P. M.; OVERS, B. J.; POLOSAN, M.; POMAROL-CLOTET, E.; RADUA, J.; CARBALLEDO, A.; RIVE, M. M.; ROBERTS, G.; RUHE, H. G.; SALVADOR, R.; Sarró S.; VELTMAN, D. J.; SATTERTHWAITE, T. D.; SAVITZ, J.; SCHENE, A. H.; SCHOFIELD, P. R.; SERPA, M. H.; CONNOLLY, C. G.; SIM, K.; SOEIRO-DE-SOUZA, M. G.; SUTHERLAND, A. N.; TEMMINGH, H. S.; PENNINX, B. W. J. H.; TIMMONS, G. M.; UHLMANN, A.; VIETA, E.; WOLF, D. H.; ZANETTI, M. V.; JAHANSHAD, N.; MARQUAND, A. F.; COLE, J. H.; SCHMAAL, L.; CULLEN, K. R.; DANNLOWSKI, U.; DAVEY, C. G.; OSIPOV, E.; DIMA, D.; DURAN, F. L. S.; ENNEKING, V.; FILIMONOVA, E.; FRENZEL, S.; FRODL, T.; FU, C. H. Y.; GODLEWSKA, B. R.; GOTLIB, I. H.; GRABE, H. J.; PORTELLA, M. J.; GROENEWOLD, N. A.; GROTEGERD, D.; GRUBER, O.; HALL, G. B.; HARRISON, B. J.; HATTON, S. N.; HERMESDORF, M.; HICKIE, I. B.; HO, T. C.; HOSTEN, N.; POZZI, E.; JANSEN, A.; KäHLER, C.; KIRCHER, T.; KLIMES-DOUGAN, B.; KRäMER, B.; KRUG, A.; LAGOPOULOS, J.; LEENINGS, R.; MACMASTER, F. P.; MACQUEEN, G.; RENEMAN, L.; MCINTOSH, A.; MCLELLAN, Q.; MCMAHON, K. L.; MEDLAND, S. E.; MUELLER, B. A.; MWANGI, B.; REPPLE, J.; ROSA, P. G. P.; SACCHET, M. D.; SäMANN, P. G.; SCHNELL, K.; SCHRANTEE, A.; GOIKOLEA, J. M.; SIMULIONYTE, E.; SOARES, J. C.; SOMMER, J.; STEIN, D. J.; STEINSTRäTER, O.; STRIKE, L. T.; THOMOPOULOS, S. I.; TOL, M.-J. van; VEER, I. M.; VERMEIREN, R. R. J. M.; HAARMAN, B. C. M.; WALTER, H.; WEE, N. J. A. van der; WERFF, S. J. A. van der; WHALLEY, H.; WINTER, N. R.; WITTFELD, K.; WRIGHT, M. J.; WU, M.-J.; VöLZKE, H.; YANG, T. T.; HAJEK, T.; ZANNIAS, V.; ZUBICARAY, G. I. de; ZUNTA-SOARES, G. B.; Abé C.; ALDA, M.; ANDREASSEN, O. A.; BøEN, E.; BONNIN, C. M.; CANALES-RODRIGUEZ, E. J.; CANNON, D.Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. © 2020, The Author(s).
- Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group(2018) HIBAR, D. P.; WESTLYE, L. T.; DOAN, N. T.; JAHANSHAD, N.; CHEUNG, J. W.; CHING, C. R. K.; VERSACE, A.; BILDERBECK, A. C.; UHLMANN, A.; MWANGI, B.; KRAEMER, B.; OVERS, B.; HARTBERG, C. B.; ABE, C.; DIMA, D.; GROTEGERD, D.; SPROOTEN, E.; BOEN, E.; JIMENEZ, E.; HOWELLS, F. M.; DELVECCHIO, G.; TEMMINGH, H.; STARKE, J.; ALMEIDA, J. R. C.; GOIKOLEA, J. M.; HOUENOU, J.; BEARD, L. M.; RAUER, L.; ABRAMOVIC, L.; BONNIN, M.; PONTEDURO, M. F.; KEIL, M.; RIVE, M. M.; YAO, N.; YALIN, N.; NAJT, P.; ROSA, P. G.; REDLICH, R.; TROST, S.; HAGENAARS, S.; FEARS, S. C.; ALONSO-LANA, S.; ERP, T. G. M. van; NICKSON, T.; CHAIM-AVANCINI, T. M.; MEIER, T. B.; ELVSASHAGEN, T.; HAUKVIK, U. K.; LEE, W. H.; SCHENE, A. H.; LLOYD, A. J.; YOUNG, A. H.; NUGENT, A.; DALE, A. M.; PFENNIG, A.; MCINTOSH, A. M.; LAFER, B.; BAUNE, B. T.; EKMAN, C. J.; ZARATE, C. A.; BEARDEN, C. E.; HENRY, C.; SIMHANDL, C.; MCDONALD, C.; BOURNE, C.; STEIN, D. J.; WOLF, D. H.; CANNON, D. M.; GLAHN, D. C.; VELTMAN, D. J.; POMAROL-CLOTET, E.; VIETA, E.; CANALES-RODRIGUEZ, E. J.; NERY, F. G.; DURAN, F. L. S.; BUSATTO, G. F.; ROBERTS, G.; PEARLSON, G. D.; GOODWIN, G. M.; KUGEL, H.; WHALLEY, H. C.; RUHE, H. G.; SOARES, J. C.; FULLERTON, J. M.; RYBAKOWSKI, J. K.; SAVITZ, J.; CHAIM, K. T.; FATJO-VILAS, M.; SOEIRO-DE-SOUZA, M. G.; BOKS, M. P.; ZANETTI, M. V.; OTADUY, M. C. G.; SCHAUFELBERGER, M. S.; ALDA, M.; INGVAR, M.; PHILLIPS, M. L.; KEMPTON, M. J.; BAUER, M.; LANDEN, M.; LAWRENCE, N. S.; HAREN, N. E. M. van; HORN, N. R.; FREIMER, N. B.; GRUBER, O.; SCHOFIELD, P. R.; MITCHELL, P. B.; KAHN, R. S.; LENROOT, R.; MACHADO-VIEIRA, R.; OPHOFF, R. A.; SARRO, S.; FRANGOU, S.; SATTERTHWAITE, T. D.; HAJEK, T.; DANNLOWSKI, U.; MALT, U. F.; AROLT, V.; GATTAZ, W. F.; DREVETS, W. C.; CASERAS, X.; AGARTZ, I.; THOMPSON, P. M.; ANDREASSEN, O. A.Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d =-0.293; P = 1.71 x 10(-21)), left fusiform gyrus (d =-0.288; P = 8.25 x 10(-21)) and left rostral middle frontal cortex (d =-0.276; P = 2.99 x 10(-19)). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.
- Frequency drift in MR spectroscopy at 3T(2021) HUI, Steve C. N.; MIKKELSEN, Mark; ZOLLNER, Helge J.; AHLUWALIA, Vishwadeep; ALCAUTER, Sarael; BALTUSIS, Laima; BARANY, Deborah A.; BARLOW, Laura R.; BECKER, Robert; I, Jeffrey Berman; BERRINGTON, Adam; BHATTACHARYYA, Pallab K.; BLICHER, Jakob Udby; BOGNER, Wolfgang; BROWN, Mark S.; CALHOUN, Vince D.; CASTILLO, Ryan; CECIL, Kim M.; CHOI, Yeo Bi; CHU, Winnie C. W.; CLARKE, William T.; CRAVEN, Alexander R.; CUYPERS, Koen; DACKO, Michael; FUENTE-SANDOVAL, Camilo de la; DESMOND, Patricia; DOMAGALIK, Aleksandra; DUMONT, Julien; DUNCAN, Niall W.; DYDAK, Ulrike; DYKE, Katherine; EDMONDSON, David A.; ENDE, Gabriele; ERSLAND, Lars; EVANS, C. John; FERMIN, Alan S. R.; FERRETTI, Antonio; FILLMER, Ariane; GONG, Tao; GREENHOUSE, Ian; GRIST, James T.; GU, Meng; HARRIS, Ashley D.; HATZ, Katarzyna; HEBA, Stefanie; HECKOVA, Eva; HEGARTY, John P.; HEISE, Kirstin-Friederike; HONDA, Shiori; JACOBSON, Aaron; JANSEN, Jacobus F. A.; JENKINS, Christopher W.; JOHNSTON, Stephen J.; JUCHEM, Christoph; KANGARLU, Alayar; KERR, Adam B.; LANDHEER, Karl; LANGE, Thomas; LEE, Phil; LEVENDOVSZKY, Swati Rane; LIMPEROPOULOS, Catherine; LIU, Feng; LLOYD, William; LYTHGOE, David J.; MACHIZAWA, Maro G.; MACMILLAN, Erin L.; MADDOCK, Richard J.; V, Andrei Manzhurtsev; MARTINEZ-GUDINO, Maria L.; MILLER, Jack J.; MIRZAKHANIAN, Heline; MORENO-ORTEGA, Marta; MULLINS, Paul G.; NAKAJIMA, Shinichiro; NEAR, Jamie; NOESKE, Ralph; NORDHOY, Wibeke; OELTZSCHNER, Georg; OSORIO-DURAN, Raul; OTADUY, Maria C. G.; PASAYE, Erick H.; PEETERS, Ronald; PELTIER, Scott J.; PILATUS, Ulrich; POLOMAC, Nenad; PORGES, Eric C.; PRADHAN, Subechhya; PRISCIANDARO, James Joseph; PUTS, Nicolaas A.; RAE, Caroline D.; REYES-MADRIGAL, Francisco; ROBERTS, Timothy P. L.; ROBERTSON, Caroline E.; ROSENBERG, Jens T.; ROTARU, Diana-Georgiana; TUURA, Ruth L. O'Gorman; SALEH, Muhammad G.; SANDBERG, Kristian; SANGILL, Ryan; SCHEMBRI, Keith; SCHRANTEE, Anouk; SEMENOVA, Natalia A.; SINGEL, Debra; SITNIKOV, Rouslan; SMITH, Jolinda; SONG, Yulu; STARK, Craig; STOFFERS, Diederick; SWINNEN, Stephan P.; TAIN, Rongwen; TANASE, Costin; TAPPER, Sofie; TEGENTHOFF, Martin; THIEL, Thomas; THIOUX, Marc; TRUONG, Peter; DIJK, Pim van; VELLA, Nolan; VIDYASAGAR, Rishma; VOVK, Andrej; WANG, Guangbin; WESTLYE, Lars T.; WILBUR, Timothy K.; WILLOUGHBY, William R.; WILSON, Martin; WITTSACK, Hans-Jorg; WOODS, Adam J.; WU, Yen-Chien; XU, Junqian; LOPEZ, Maria Yanez; YEUNG, David K. W.; ZHAO, Qun; ZHOU, Xiaopeng; ZUPAN, Gasper; EDDEN, Richard A. E.Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B-0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift data from a large number of sites. Method: A standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Phantom water signals were acquired before and after an EPI sequence. The protocol consisted of: minimal preparatory imaging; a short pre-fMRI PRESS; a ten-minute fMRI acquisition; and a long post-fMRI PRESS acquisition. Both pre- and post-fMRI PRESS were non-water suppressed. Real-time frequency stabilization/adjustment was switched off when appropriate. Sixty scanners repeated the protocol for a second dataset. In addition, a three-hour post-fMRI MRS acquisition was performed at one site to observe change of gradient temperature and drift rate. Spectral analysis was performed using MATLAB. Frequency drift in pre-fMRI PRESS data were compared with the first 5:20 minutes and the full 30:00 minutes of data after fMRI. Median (interquartile range) drifts were measured and showed in violin plot. Paired t-tests were performed to compare frequency drift pre- and post-fMRI. A simulated in vivo spectrum was generated using FID-A to visualize the effect of the observed frequency drifts. The simulated spectrum was convolved with the frequency trace for the most extreme cases. Impacts of frequency drifts on NAA and GABA were also simulated as a function of linear drift. Data from the repeated protocol were compared with the corresponding first dataset using Pearson's and intraclass correlation coefficients (ICC). Results: Of the data collected from 99 scanners, 4 were excluded due to various reasons. Thus, data from 95 scanners were ultimately analyzed. For the first 5:20 min (64 transients), median (interquartile range) drift was 0.44 (1.29) Hz before fMRI and 0.83 (1.29) Hz after. This increased to 3.15 (4.02) Hz for the full 30 min (360 transients) run. Average drift rates were 0.29 Hz/min before fMRI and 0.43 Hz/min after. Paired t-tests indicated that drift increased after fMRI, as expected (p < 0.05). Simulated spectra convolved with the frequency drift showed that the intensity of the NAA singlet was reduced by up to 26%, 44 % and 18% for GE, Philips and Siemens scanners after fMRI, respectively. ICCs indicated good agreement between datasets acquired on separate days. The single site long acquisition showed drift rate was reduced to 0.03 Hz/min approximately three hours after fMRI. Discussion: This study analyzed frequency drift data from 95 3T MRI scanners. Median levels of drift were relatively low (5-min average under 1 Hz), but the most extreme cases suffered from higher levels of drift. The extent of drift varied across scanners which both linear and nonlinear drifts were observed.
conferenceObject DIFFUSION TENSOR IMAGING ABNORMALITIES OF THE CORPUS CALLOSUM IN MALFORMATIONS OF CORTICAL DEVELOPMENT(2014) ANDRADE, C. S.; LEITE, C. C.; OTADUY, M. C. G.; LYRA, K. P.; VALENTE, K. D. R.; YASUDA, C. L.; BELTRAMINI, G. C.; BEAULIEU, C.; GROSS, D. W.- DTI-derived parameters differ between moderate and severe traumatic brain injury and its association with psychiatric scores(2022) ZANINOTTO, Ana Luiza; GRASSI, Daphine Centola; DUARTE, Dante; RODRIGUES, Priscila Aparecida; CARDOSO, Ellison; FELTRIN, Fabricio Stewan; GUIRADO, Vinicius Monteiro de Paula; MACRUZ, Fabiola Bezerra de Carvalho; OTADUY, Maria Concepcion Garcia; LEITE, Claudia da Costa; PAIVA, Wellingson Silva; ANDRADE, Celi SantosBackground and aim Diffusion tensor imaging (DTI) parameters in the corpus callosum have been suggested to be a biomarker for prognostic outcomes in individuals with diffuse axonal injury (DAI). However, differences between the DTI parameters on moderate and severe trauma in DAI over time are still unclear. A secondary goal was to study the association between the changes in the DTI parameters, anxiety, and depressive scores in DAI over time. Methods Twenty subjects were recruited from a neurological outpatient clinic and evaluated at 2, 6, and 12 months after the brain injury and compared to matched age and sex healthy controls regarding the DTI parameters in the corpus callosum. State-Trace Anxiety Inventory and Beck Depression Inventory were used to assess psychiatric outcomes in the TBI group over time. Results Differences were observed in the fractional anisotropy and mean diffusivity of the genu, body, and splenium of the corpus callosum between DAI and controls (p < 0.02). Differences in both parameters in the genu of the corpus callosum were also detected between patients with moderate and severe DAI (p < 0.05). There was an increase in the mean diffusivity values and the fractional anisotropy decrease in the DAI group over time (p < 0.02). There was no significant correlation between changes in the fractional anisotropy and mean diffusivity across the study and psychiatric outcomes in DAI. Conclusion DTI parameters, specifically the mean diffusivity in the corpus callosum, may provide reliable characterization and quantification of differences determined by the brain injury severity. No correlation was observed with DAI parameters and the psychiatric outcome scores.
- Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases(2019) BETTS, Matthew J.; KIRILINA, Evgeniya; OTADUY, Maria C. G.; IVANOV, Dimo; ACOSTA-CABRONERO, Julio; CALLAGHAN, Martina F.; LAMBERT, Christian; CARDENAS-BLANCO, Arturo; PINE, Kerrin; PASSAMONTI, Luca; LOANE, Clare; KEUKEN, Max C.; TRUJILLO, Paula; LUESEBRINK, Falk; MATTERN, Hendrik; LIU, Kathy Y.; PRIOVOULOS, Nikos; FLIESSBACH, Klaus; DAHL, Martin J.; MAASS, Anne; MADELUNG, Christopher F.; MEDER, David; EHRENBERG, Alexander J.; SPECK, Oliver; WEISKOPF, Nikolaus; DOLAN, Raymond; INGLIS, Ben; TOSUN, Duygu; MORAWSKI, Markus; ZUCCA, Fabio A.; SIEBNER, Hartwig R.; MATHER, Mara; ULUDAG, Kamil; HEINSEN, Helmut; POSER, Benedikt A.; HOWARD, Robert; ZECCA, Luigi; ROWE, James B.; GRINBERG, Lea T.; JACOBS, Heidi I. L.; DUEZEL, Emrah; HAEMMERER, DorotheaPathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer's disease, atypical neurodegenerative dementias and Parkinson's disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.