MIGUEL SROUGI
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cirurgia, Faculdade de Medicina - Docente
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina - Líder
33 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 33
- Correlation of a microRNA expression profile and the prognosis of penile cancer: A prospective study using microarray data analysis(2018) FURUYA, Tatiane K.; MURTA, Claudio B.; PONTES JR., Jose; UNO, Miyuki; CARRASCO, Alexis; SICHERO, Laura C.; VILLA, Luisa L.; COELHO, Rafael F.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio D.; LEITE, Katia R.; SROUGI, Miguel; CHAMMAS, Roger; NAHAS, William C.
- Assessment of a new kind of surgical simulator. The physical surgical simulator(2018) CRUZ, Jose Arnaldo Shiomi da; MIRANDA, Andre Filipe; COSTA, Lucas Evangelista da; AZEVEDO, Rafael Ulysses de; REIS, Sabrina Thalita dos; SROUGI, Miguel; PASSEROTTI, Carlo CamargoPurpose: To evaluate whether the use of the physical surgical simulator may benefit the development of laparoscopic skills. Methods: Ten medical students were divided into two groups: the first one performed ten weekly training sessions with a physical surgical simulator - ETX A2 LAP and, afterwards, one laparoscopic cholecystectomy in a porcine model, while the second group performed only a laparoscopic cholecystectomy. Both groups were compared regarding bleeding, total surgical time, time to perform each surgical step and qualitative parameters, based on a previously validated tool. Results: There was no difference in any of the evaluated parameters. Conclusion: We did not find any evidence of benefit in the use of the physical simulator for surgical performance in medical students.
bookPart Prefácio(2018) SROUGI, Miguel- Predictive factors for prolonged hospital stay after retropublic radical prostatectomy in a high-volume teaching center(2018) COELHO, Rafael F.; CORDEIRO, Mauricio D.; PADOVANI, Guilherme P.; LOCALLI, Rafael; FONSECA, Limirio; PONTES JUNIOR, Jose; GUGLIELMETTI, Giuliano B.; SROUGI, Miguel; NAHAS, William CarlosObjective: To evaluate the length hospital stay and predictors of prolonged hospitalization after RRP performed in a high-surgical volume teaching institution, and analyze the rate of unplanned visits to the office, emergency care, hospital readmissions and perioperative complications rates. Materials and Methods: Retrospective analysis of prospectively collected data in a standardized database for patients with localized prostate cancer undergoing RRP in our institution between January/2010 - January/2012. A logistic regression model including preoperative variables was initially built in order to determine the factors that predict prolonged hospital stay before the surgical procedure; subsequently, a second model including both pre and intraoperative variables was analyzed. Results: 1011 patients underwent RRP at our institution were evaluated. The median hospital stay was 2 days, and 217 (21.5%) patients had prolonged hospitalization. Predictors of prolonged hospital stay among the preoperative variables were ICC (OR. 1.40 p=0.003), age (OR 1.050 p<0.001), ASA score of 3 (OR. 3.260 p<0.001), prostate volume on USG-TR (OR, 1.005 p=0.038) and African-American race (OR 2.235 p=0.004); among intra and postoperative factors, operative time (OR 1.007 p=0.022) and the presence of any complications (OR 2.013 p=0.009) or major complications (OR 2.357 p=0.01) were also correlated independently with prolonged hospital stay. The complication rate was 14.5%. Conclusions: The independent predictors of prolonged hospitalization among preoperative variables were CCI, age, ASA score of 3, prostate volume on USG-TR and African-American race; amongst intra and postoperative factors, operative time, presence of any complications and major complications were correlated independently with prolonged hospital stay.
- Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention(2018) PUCCI, Nidia D.; MARCHINI, Giovanni S.; MAZZUCCHI, Eduardo; REIS, Sabrina T.; SROUGI, Miguel; EVAZIAN, Denise; NAHAS, William C.Phyllanthus niruri (P.niruri) or stone breaker is a plant commonly used to reduce stone risk, however, clinical studies on this issue are lacking. Objective: To prospectively evaluate the effect of P. niruri on the urinary metabolic parameters of patients with urinary lithiasis. Materials and Methods: We studied 56 patients with kidney stones < 10mm. Clinical, metabolic, and ultrasonography assessment was conducted before (baseline) the use of P. niruri infusion for 12-weeks (P. niruri) and after a 12-week (wash out) Statistical analysis included ANOVA for repeated measures and Tukey's/McNemar's test for categorical variables. Significance was set at 5%. Results: Mean age was 44 +/- 9.2 and BMI was 27.2 +/- 4.4kg/m2. Thirty-six patients (64%) were women. There were no significant changes in all periods for anthropometric and several serum measurements, including total blood count, creatinine, uric acid, sodium, potassium, calcium, urine volume and pH; a significant increase in urinary potassium from 50.5 +/- 20.4 to 56.2 +/- 21.8 mg/24-hour (p=0.017); magnesium/creatinine ratio 58 +/- 22.5 to 69.1 +/- 28.6mg/gCr24-hour (p=0.013) and potassium/creatinine ratio 39.3 +/- 15.1 to 51.3 +/- 34.7mg/gCr24hour (p=0.008) from baseline to wash out. The kidney stones decreased from 3.2 +/- 2 to 2.0 +/- 2per patient (p<0.001). In hyperoxaluria patients, urinary oxalate reduced from 59.0 +/- 11.7 to 28.8 +/- 16.0mg/24-hour (p=0.0002), and in hyperuricosuria there was a decrease in urinary uric acid from 0.77 +/- 0.22 to 0.54 +/- 0.07mg/24-hour (p=0.0057). Conclusions: P. niruri intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P. niruri contributed to the elimination of urinary calculi.
conferenceObject SPORADIC PRIMARY HYPERPARATHYROIDISM AND STONE DISEASE: A COMPREHENSIVE METABOLIC EVALUATION BEFORE AND AFTER PARATHYROIDECTOMY(2018) MARCHINI, Giovanni; FARIA, Kauy; TORRICELLI, Fabio; MONGA, Manoj; VICENTINI, Fabio; DANILOVIC, Alexandre; SROUGI, Miguel; NAHAS, William; MAZZUCCHI, Eduardo- Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication(2018) GODOY-SANTOS, Alexandre Leme; BRUSCHINI, Homero; CURY, Jose; SROUGI, Miguel; CESAR-NETTO, Cesar de; FONSECA, Lucas F.; MAFFULLI, NicolaOBJECTIVE To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment. METHODS Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017. RESULTS A total of 79 articles were used, with ciprofloxacin representing the most common drug. CONCLUSION We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders. (C) 2017 Elsevier Inc.
conferenceObject IN VITRO EVALUATION OF SINGLE-USE DIGITAL FLEXIBLE URETEROSCOPES: A PRACTICAL COMPARISON FOR A PATIENT-CENTERED APPROACH(2018) MARCHINI, Giovanni; BATAGELLO, Carlos; MONGA, Manoj; TORRICELLI, Fabio; VICENTINI, Fabio; DANILOVIC, Alexandre; SROUGI, Miguel; NAHAS, William; MAZZUCCHI, Eduardo- Distinct urinary glycoprotein signatures in prostate cancer patients(2018) KAWAHARA, R.; ORTEGA, F.; ROSA-FERNANDES, L.; GUIMARãES, V.; QUINA, D.; NAHAS, W.; SCHWäMMLE, V.; SROUGI, M.; LEITE, K. R. M.; THAYSEN-ANDERSEN, M.; LARSEN, M. R.; PALMISANO, G.Novel biomarkers are needed to complement prostate specific antigen (PSA) in prostate cancer (PCa) diagnostic screening programs. Glycoproteins represent a hitherto largely untapped resource with a great potential as specific and sensitive tumor biomarkers due to their abundance in bodily fluids and their dynamic and cancer-associated glycosylation. However, quantitative glycoproteomics strategies to detect potential glycoprotein cancer markers from complex biospecimen are only just emerging. Here, we describe a glycoproteomics strategy for deep quantitative mapping of N- and O-glycoproteins in urine with a view to investigate the diagnostic value of the glycoproteome to discriminate PCa from benign prostatic hyperplasia (BPH), two conditions that remain difficult to clinically stratify. Total protein extracts were obtained, concentrated and digested from urine of six PCa patients (Gleason score 7) and six BPH patients. The resulting peptide mixtures were TMT-labeled and mixed prior to a multi-faceted sample processing including hydrophilic interaction liquid chromatography (HILIC) and titanium dioxide SPE based enrichment, endo-/exoglycosidase treatment and HILIC-HPLC pre-fractionation. The isolated N- and O-glycopeptides were detected and quantified using high resolution mass spectrometry. We accurately quantified 729 N-glycoproteins spanning 1,310 unique N-glycosylation sites and observed 954 and 965 unique intact N- and O-glycopeptides, respectively, across the two disease conditions. Importantly, a panel of 56 intact N-glycopeptides perfectly discriminated PCa and BPH (ROC: AUC = 1). This study has generated a panel of intact glycopeptides that has a potential for PCa detection. © Kawahara et al.
- Current trends of percutaneous nephrolithotomy in a developing country(2018) BATAGELLO, Carlos A.; VICENTINI, Fabio Carvalho; MARCHINI, Giovanni Scala; TORRICELLI, Fabio Cesar Miranda; SROUGI, Miguel; NAHAS, Willian Carlos; MAZZUCCHI, EduardoIntroduction: To present the current practice patterns on percutaneous nephrolithotomy (PCNL) in a developing country. Materials and Methods: A survey was offered to Brazilian urologists during the II International Endourology Symposium held in Sao Paulo, in 2015. The first seven questions were related to demographic data while the 20 remaining were directed to urologists who performed PCNL. Results: From 250 participants, 100 replied to the survey, 81% performed PCNL and 60.4% of performers had been in practice for less than 15 years. Eighty-one percent were trained in the prone position and 64% in supine. PCNL was learned during the residency in 66.7% and 2.5% had fellowship training. Prone position was the preferred decubitus for simple or complex calculi, though for obese patients there was no difference. Younger surgeons prefer supine while older surgeons prefer prone. The access was obtained by the surgeon in all cases, 96.3% use fluoroscopy and 3.7% prefer ultrasonography. Forty-seven percent use ultrasonic lithotripters and 4.1% laser. For kidney drainage, 71.6% place a nephrostomy tube. Double J stent is left in 77%. The postoperative image method was CT for 50%. Colonic injury was reported by 25%, predominantly in the senior group without statistically difference between positions. Conclusions: From a selected group of urologists, we observe that Brazilian urologists usually gain their own access for PCNL guided by fluoroscopy. They predominantly prefer the prone position, use fascial dilators, ultrasonic lithotripters and place a nephrostomy tube when exiting the kidney. Fellowship programs, ultrasonography, flexible nephoscopy and tubeless procedures could be encouraged.