SOLANGE CARRASCO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
conferenceObject INFLUENCE OF ALPHA 2 DO COLLAGEN V OVEREXPRESSION IN PHYSIOPHATOLOGY OF FIBROSIS SYSTEMIC SCLEROSIS PATIENTS(2014) MORAIS, J.; MARTIN, P.; VELOSA, A. P. P.; ANDRADE, P. C.; CRUZ, I. B.; MIRACCA, E. C.; FAC, F. A. C. Barrence; CARRASCO, S.; GOLDEINSTEIN-SCHAINBERG, C.; NAGAI, M. A.; PARRA, E. R.; CAPELOZZI, V. L.; TEODORO, W. R.conferenceObject HLA-B27 PREVALENCE IN A COHORT OF BRAZILIAN PATIENTS WITH PSORIATIC ARTHRITIS AND ANKYLOSING SPONDYLITIS(2014) GOLDENSTEIN-SCHAINBERG, C.; CARRASCO, S.; SAAD, C. G.; MORAES, J. C. B.; GONCALVES, C. R.; SAMPAIO-BARROS, P.; PARRA, E. R.conferenceObject PREVALENCE AND CHARACTERIZATION OF PSORIATIC ARTHRITIS MUTILANS PATIENTS FROM A SINGLE TERTIARY CENTER(2018) OLIVEIRA, J. L.; CORDEIRO, R. A.; CARRASCO, S.; GONCALVES, C. R.; MORAES, J. C. B.; SAAD, C. G. S.; SAMPAIO-BARROS, P. D.; GOLDENSTEIN-SCHAINBERG, C.conferenceObject ANTI-ENDOTHELIAL CELL ANTIBODIES AS BIOMARKER OF SEVERE VASCULAR MANIFESTATIONS IN SYSTEMIC SCLEROSIS(2014) VAHOS, C. Munoz; GOLDENSTEIN-SCHAINBERG, C.; VIANA, V. S.; CARRASCO, S.; LEON, E. P.; BONFA, E.; VASQUEZ, G.; SAMPAIO-BARROS, P. D.conferenceObject INCREASED TOLL LIKE RECEPTOR 2 (TLR2) EXPRESSION ON PERIPHERAL BLOOD MONOCYTES FROM PATIENTS WITH ANTI-TNF INDUCED PSORIASIS SUGGESTS A ROLE FOR A GRAM-POSITIVE INFLAMMATORY TRIGGER(2016) VALKINIR, D. E. J.; FERNANDEZ, V. V.; NOGUEIRA, M. A. D. S.; ROMITI, R.; AMONE, M.; HIRAYAMA, A. L. D. S.; TAKAHASHI, M. D. F.; CARRASCO, S.; SAMPAIO-BARROS, P.; MORAES, J.; GONCALVES, C.; SAAD, C.; GOLDENSTEIN-SCHAINBERG, C.article Toll-like receptor (TLR) 2 is upregulated on peripheral blood monocytes of patients with psoriatic arthritis: a role for a gram-positive inflammatory trigger?(2011) CARRASCO, S.; NEVES, F. S.; FONSECA, M. H.; GONCALVES, C. R.; SAAD, C. G.; SAMPAIO-BARROS, P. D.; GOLDENSTEIN-SCHAINBERG, C.Toll-like receptor (TLR) 2 and TLR4 are able to activate innate immune cells in response to gram-positive and gram-negative bacteria, respectively. Psoriatic arthritis (PsA) is a chronic inflammatory joint disease and gram-positive streptococcus may have a role in its pathogenesis, suggesting the importance of TLR2 stimulation in PsA. Objective To assess TLR2 and TLR4 expressions on innate immune cells of PsA patients, relating to clinical disease activity. Methods Fort-five patients with peripheral joint manifestations of PsA were included and disease activity was assessed by Disease Activity Score of 28 joint counts (DAS28). 32 healthy subjects constituted the control group. Membrane-bound TLR2 and TLR4 expressions were assessed on peripheral blood monocytes and neutrophils by flow cytometry. Results Twenty-seven patients had active PsA (DAS28 higher than 2.6) and 18 had inactive disease. TLR2 was significantly upregulated on monocytes in both active and inactive PsA group, comparing to healthy controls. TLR4 was similarly expressed in all tested groups. Conclusion TLR2 is overexpressed by PsA monocytes, suggesting that gram-positive exposure could induce higher inflammatory responses in this disease.conferenceObject ALPHA2 (V) CHAIN AND COLVA2 INDUCES THE FIBRILLOGENESIS PROCESS IN DISTORTEDLUNG FRAMEWORK OF SYSTEMIC SCLEROSIS(2014) ANDRADE, P. C.; VELOSA, A. P. P.; MORAIS, J.; RANGEL, M. P.; CARRASCO, S.; CHISTMANN, R. B.; PARRA, E. R.; CAPELLOZZI, V. L.; TEODORO, W. R.conferenceObject OVEREXPRESSION OF TOLL-LIKE RECEPTOR 2 ON PERIPHERAL BLOOD MONOCYTES FROM PATIENTS WITH PSORIATIC ARTHRITIS (PsA)(2012) CARRASCO, S.; NEVES, F. S.; GAMBIM, M.; SAAD, C. G.; GONCALVES, C.; SAMPAIO-BARROS, P.; GOLDENSTEIN-SCHAINBERG, C.Toll-like receptor (TLR) 2 and TLR4 are able to activate innate immune cells in response to gram-positive and gramnegative bacteria, respectively. Psoriatic arthritis (PsA) is a chronic inflammatory joint disease and gram-positive streptococcus may have a role in its pathogenesis, suggesting the importance of TLR2 stimulation in PsA. OBJECTIVES: To assess TLR2 and TLR4 expressions on innate immune cells of PsA patients, relating to clinical disease activity. METHODS: Forty-five patients with peripheral joint manifestations of PsA were included and disease activity was assessed by Disease Activity Score of 28 joint counts (DAS28). 32 healthy subjects constituted the control group. Membrane-bound TLR2 and TLR4 expressions were assessed on peripheral blood monocytes and neutrophils by flow cytometry. RESULTS: Twenty-seven patients had active PsA (DAS28 higher than 2.6) and 18 had inactive disease. TLR2 was significantly upregulated on monocytes in both active and inactive PsA group, comparing to healthy controls. TLR4 was similarly expressed in all tested groups. CONCLUSIONS: TLR2 is overexpressed by PsA monocytes, suggesting that gram-positive exposure could induce higher inflammatory responses in this disease.conferenceObject JUVENILE SPONDYLOARTHRITIS (JSpA) IN A COHORT OF BRAZILIAN PATIENTS(2014) PEREZ, M. O.; AIKAWA, N. E.; CARRASCO, S.; SAMPAIO-BARROS, P. D.; GONCALVES, C. R.; SAAD, C. G. S.; MORAES, J. C. B.; GOLDENSTEIN-SCHAINBERG, C.